Jeffrey Y.C. Wong, M.D.
- Genitourinary Cancers
- Hematologic Malignancies
- Image-guided Intensity Modulated Radiation Therapy/TomoTherapy
- Total Body Irradiation and Total Marrow Irradiation
- Targeted Radiopharmaceutical Therapy
- Radioimmunotherapy
- Radiation Treatment for Hematologic, Genitourinary and Gastrointestinal Cancers
- Focused Ultrasound
- Professor, Department of Radiation Oncology
- Professor, Department of Immunology & Theranostics
- Co-director, Center for Theranostic Studies
We want to make a difference not only today....but also for tomorrow, for future generations.
For more than 25 years, Jeffrey Y.C. Wong, M.D., guided City of Hope’s Department of Radiation Oncology through unprecedented growth. The program now boasts the latest technologies, including image-guided/ intensity modulated radiation therapy, image-guided radiation therapy, TomoTherapy, CT simulation, functional tumor imaging, radioimmunotherapy and advanced brachytherapy technologies.
Dr. Wong, a graduate of Johns Hopkins University, is currently co-director of City of Hope’s leading-edge Center for Theranostic Studies, which enables clinicians to find and treat tumor cells at the same time.
His primary areas of research include the development of novel strategies and agents for image-guided and biologically targeted radiation therapy for patients with locoregional and systemic disease.
Dr. Wong’s team pioneered and developed the use of a targeted form of bone marrow irradiation, treating the first case in 2005, in a collaborative effort between the Department of Radiation Oncology and the bone marrow transplant program. Since 2002, he has helped lead a team to develop and clinically evaluate a new method of delivering a more targeted form of total body irradiation (TBI) that uses large field image-guided/intensity modulated radiotherapy (IMRT) in patients undergoing hematopoietic cell transplantations for a variety of advanced hematologic malignancies. His team was the first in the world to use this method, total marrow irradiation (TMI) or total marrow and lymphoid irradiation (TMLI), on patients. This approach provides the treating oncologist much more control of dose delivery to target areas and dose avoidance of normal organs.
He has been involved with the development and implementation of TMLI protocols at City of Hope, and has also helped to lead the effort to use TomoTherapy and VMAT to deliver TBI. A TMI database has been developed to capture data for patients receiving IMRT-based TBI, TMI and TMLI worldwide. His team has collaborated with centers in Asia and Europe to initiate TMI and TMLI programs.
As co-director of the Center for Theranostic Studies, Dr. Wong works on the development and use of targeted radiopharmaceuticals for therapy, imaging and image-guided radiotherapy, focusing on the development and clinical evaluation of radiolabeled antibodies for the last 25 years. He helps lead a team that brings new agents developed in City of Hope labs to the clinic. He has been the principal investigator of over 20, and co-principal investigator on an additional three, radioimmunotherapy clinical trials. These agents have been used to treat patients with colorectal cancers, other gastrointestinal cancers and cancers of the breast, thyroid and lung.
Location
Duarte Cancer Center
Duarte, CA 91010
Education & Experience
1985, American Board of Radiology - Therapeutic Radiology
1981,M.D., Medicine, Johns Hopkins University, Baltimore, Maryland, Medicine
1977, B.S., Biology, Stanford University, Palo Alto, California
1982-985, Radiation Oncology, University of California San Francisco, San Francisco, California
2021-present, Professor, Department of Radiation Oncology, City of Hope, Duarte, CA
2021-present, Professor, Department of Immunology & Theranostics, City of Hope, Duarte, CA
1998-2020, Chair, Department of Radiation Oncology, City of Hope, Duarte, CA
1998-present, Medical Director, School of Radiation Therapy Technology, City of Hope, Duarte, CA
1992-2004, Director, Division of Radiation Research, Department of Radiation Oncology, City of Hope, Duarte, CA
Awards & Memberships
Memberships
American Society for Therapeutic Radiology and Oncology
Society of Chairs of Academic Radiation Oncology Programs
American Society of Clinical Oncology
Radiation Research Society
American Society for Blood and Marrow Transplantation
Publications
Most recent publications below, additional ones are listed here on PubMed.
- Zuro D, Madabushi SS, Brooks J, Chen BT, Goud J, Salhotra A, Song JY, Parra LE, Pierini A, Sanchez JF, Stein A, Al Malki M, Kortylewski M, Wong JYC, Alaei P, Froelich J, Storme G, Hui SK. First Multimodal, Three-Dimensional, Image-Guided Total Marrow Irradiation Model for Preclinical Bone Marrow Transplantation Studies Short Running Title: Preclinical TMI model. International J Radiation Onoclogy Biology and Physics, in press.
- D’Amico AV, Xie W, McMahon E, Loffredo M, Medeiros S, Joseph D, Dedham J, Lamb D, Jackson C, Kumar P, Bubley G, Sullivan M, Basile F, Hellwig R, Chingos J, Vera JC, Freter R, Constantine M, Baker WJ, Wong JY, Renshaw AA, Kantoff PW. MD. Radiation and Androgen Suppression Therapy with or without Docetaxel in the Management of Non-Metastatic Unfavorable-Risk Prostate Cancer: A Prospective Randomized Trial. JCO in press.
- Morris M, Rowe S, Gorin M, Saperstein L, Pouliot F, Josephson D, Wong J, Pantel A, Cho S, Gage K, Piert M, Iagaru A, Pollard J, Wong V, Jensen J, Lin T, Stambler N, Carroll P, Siegel B, Wibmer A, Durack J, Solomon S, Harb R, Pucar D, Sprenkle P, Beauregard J-M, Beaulieu A, Buteau F-A, Yamauchi D, Glaser S, Dorff T, Narayan V, Fillare M, Schubert E, Cooley G, Morris Z, Langeland M, Pow-Sang J, Yamoah K, Alva A, Reichert Z, Spratt D, Davidzon G, Aparici CM, Moradi F, Tracy C, Behr S, Nguyen H, Simko J, Jennings J, Michalski J, Pachynski R. Diagnostic Performance of 18F-DCFPyL-PET/CT in Men with Biochemically Recurrent Prostate Cancer: Results from the CONDOR Phase 3, Multicenter Study. Clinical Cancer Research in press, February 2021
- Krishnan A, Adhikarla V, Poku EK, Palmer J, Chaudhry A, Biglang-awa VE, Bowles N, Nathwani N, Rosenzweig M, Sahebi F, Karanes C, Simpson J, Sanchez JF, Yamauchi D, Parayno M, Chowdhury A, Caserta E, Marcucci G, Rockne R, Wu A, Wong J, Forman SJ, Colcher D, Yazaki P, Shively J, Pichiorri F. Identifying CD38+ cells in patients with multiple myeloma: First-in-human imaging using copper-64-labeled daratumumab. Blood Adv. 2020 Oct 27;4(20):5194-5202. doi: 10.1182/bloodadvances.2020002603. PMID: 33095874
- Minnix M, Li L, Yazaki PJ, Miller AD, Chea J, Poku E, Liu A, Wong JYC, Rockne RR, Colcher D, Shively JE. TAG-72 targeted α-radionuclide therapy of ovarian cancer using actinium-225 labeled DOTAylated-huCC49 antibody. J Nucl Med. 62: 55-61, 2021
- Han C, Da Silva AJ, Liang J, Wohlers C, Huntzinger C, Neylon JP, Du D, Wong JYC, Liu A. Comparative evaluation of treatment plan quality for a prototype biology-guided radiotherapy system in the treatment of nasopharyngeal carcinoma. Medical Dosimetry, Med Dosim. 2021 Summer;46(2):171-178. doi: 10.1016/j.meddos.2020.11.002. Epub 2020 Nov 30.
- Li R, Shinde A, Liu A, Glaser SM, Lyou Y Wong JY, Amini A. Machine learning-based interpretation and visualization of nonlinear interactions in prostate cancer survival. Journal of Clinical Oncology Clinical Cancer Informatics, Accepted, 2020.
- Yan J, Liu A, Glaser S, Liang I Zhang F, Wong J, Chen Y-J. Quantitative analyses of vaginal wall thickness variability in vaginal cuff brachytherapy –multichannel balloon vs. single-channel brachytherapy. American J Biomedical Science and Research, 11:509-513, February, 2021.
- Han C, Liu A, Wong JYC. Estimation of radiation-induced organ-specific secondary solid tumor occurrence rates with total body irradiation and total body irradiation and total marrow irradiation treatments. Practical Radiation Oncology, 10: e406-E414, 2020.
- Wong JYC, Filippi AR, Scorsetti M, Hui S, Muren LP, Mancosu P. Total marrow irradiation or total marrow and lymphoid irradiation in bone marrow transplantation for acute leukaemia. Lancet Oncology, 21:e477-e487, October 2020.
- Wong P, Li L, Chea J, Hu W, Poku E, Ebner T, Bowles N, Wong JYC, Yazaki P, Sligar S, Shively JE. Antibody targeted PET imaging of 64Cu-DOTA-Anti-CEA PEGylated lipid nanodiscs in CEA positive tumors. Bioconjugate Chemistry, 31(3):743-753, 2020.
- Akhavan D, Yazaki P, Yamauchi D, Simpson J, Frankel PH, Bading J, Colcher D, Poku K, Chen Y-J, Lim D, Cristea M, Wu A, Shively J, Wong JYC. Phase I study of Yttrium-90 radiolabeled M5A anti-CEA humanized antibody in patients with advanced CEA producing malignancies. Cancer Biotherapy & Radiopharmaceuticals, 35(1):10-15, 2020.
- Liu RJ, Yang SX, Neylon J, Hall MD, Dandapani S, Vora N, Wong JYC, Liu A. Residual setup errors in cranial stereotactic radiosurgery without six degree of freedom robotic couch: Frameless versus rigid immobilization systems. Journal of Applied Clinical Medical Physics, 21(3):87-93, 2020.
- Jacobs A, Guyon T, Headley V, Nair M, Rickets W, Gray G, Wong J, Chao N, Terbrueggen R. Role of a high throughput biodosimetry test in treatment prioritization after a nuclear incident. Int. J. Radiat. Oncol. Biol. Phys., 96(1):57-66, 2020.
- Sampath S, Frankel P, del Vecchio B, Ruel N, Yuh B, Liu A, Tsai T, Wong J. Stereotactic body radiation therapy to the prostate bed: Results of a Phase 1 dose-escalation trial. Int. J. Radiat. Oncol. Biol. Phys., 106(3):537-545, 2020.
- Salholtra A, Hui S, Yang D, Mokhtari S, Mei M, Al Malki MM, Aldoss I, Ali H, Sandhu KS, Aribi A, Khaled S, Dandapani S, Peng K, Berano Teh J, Murata-Collins J, Budde E, Dadwal S, Pullarkat V, Snyder D, Spielberger R, Wong J, Armenian S, Marcucci G, Forman SJ, Nakamura R, Stein A. Long-term outcomes of patients with acute myelogenous leukemia treated with myeloablative fractionated total body irradiation TBI-based conditioning with a Tacrolimus- and Simolimus-based graft-versus-host disease prophylaxis regimen: 6-year follow-up from a single center. Biology of Blood and Marrow Transplantation, 26: 292-299, 2020.
- Shinde A, Yang D, Frankel P, Liu A, Han C, Del Vecchio B, Schultheiss T, Cheng J, Li R, Kim D, Radany EH, Hui S, Somlo G, Rosenthal J, Stein A, Forman S, Wong JYC. Radiation related toxicities using organ sparing total marrow irradiation transplant conditioning regimens. Int. J. Radiat. Oncol. Biol. Phys.,
105(5):1025-1033, 2019. - Mikhaylova E, Brooks J, Zuro D, Nouizi F, Kujawski M, Madabushi SS, Qi J, Zhang M, Chea J, Poku EK, Bowles N, Wong JYC, Shively JE, Yazaki PJ, Gultekin G, Cherry SR, Hui S. Prototype small-animal PET-CT imaging system for image-guided radiation therapy. IEEE Access, Vol. 7:143207-143216, 2019.
- Zuro D, Vagge S, Broggi S, Agostinelli S, Takahashi Y, Brooks J, Leszcynska P, Liu A, Zucchetti C, Saldi S, Han C, Cattaneo M, Giebel S, Mahe MA, Sanchez JF, Alaei P, Anna C, Dusenbery K, Pierini A, Storme G, Aristei C, Wong JYC, Hui S. Multi-institutional evaluation of MVCT guided patient registration and dosimetric precision in total marrow irradiation: A global health initiative by the international consortium of total marrow irradiation. Radiotherapy and Oncology, 141: 275-282, 2019.
- Sampath S, Rahmanuddin S, Sahoo P, Frankel P, Wong J, Boswell S, Rotter A, Rockne R, Wong J, Park J. Change in apparent diffusion coefficient is associated with local failure after stereotactic body radiation therapy for non-small cell lung cancer: a prospective clinical trial. Int. J. Radiat. Oncol. Biol. Phys., 105(3):659-663, 2019.
- Srideshikan SM, Brooks J, Zuro D, Kumar B, Sanchez J, Parra LE, Orellana M, Vishwasrao P, Nair I, Chea J, Poku K, Bowles N, Miller A, Ebner T, Molnar J, Rosenthal J, Vallera DA, Wong JYC, Stein AS, Colcher D, Shively JE, Yazaki PJ, Hui SK. ImmunoPET, [64Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML xenograft model. Clinical Cancer Research, 25(24): 7463-7474, 2019.