An NCI-designated Comprehensive Cancer Center
Generic CV Bio Profile

Keane Lai, M.D.

Pathologist
Appointments
Associate Clinical Professor, Department of Pathology

Locations

City of Hope Comprehensive Cancer Center, 1500 East Duarte Road

Duarte, CA 91010

  • Ono M*, Lai KKY*, et al. Nuclear receptor/Wnt beta-catenin interactions are regulated via differential CBP/p300 coactivator usage. PLoS One 13(7):e0200714, 2018. (*Equal contribution.)
  • Manegold P*, Lai KKY*, Wu Y, Teo JL, Lenz HJ, Genyk YS, Pandol SJ, Wu K, Lin DP, Chen Y, Nguyen C, Zhao Y, Kahn M. Differentiation Therapy Targeting the β-Catenin/CBP Interaction in Pancreatic Cancer. Cancers 10(4). pii: E95, 2018. PubMed PMID: 29596326. (*Equal contribution.)
  • Lai KKY*, Kweon SM*, Chi F*, Hwang E*, Kabe Y, Higashiyama R, Qin L, Yan R, Wu RP, Lai K, Fujii N, French S, Xu J, Wang JY, Murali R, Mishra L, Lee JS, Ntambi JM, Tsukamoto H. Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6. Gastroenterology, 152(6):1477-1491, 2017. PubMed PMID: 28143772. (*Equal contribution)
  • Kweon SM, Chi F, Higashiyama R, Lai K, Tsukamoto H. Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells. PLoS One 11(5):e0156111, 2016. PubMed PMID: 27214381.
  • Lee Y, Lai KK, Sadrzadeh SM. Simultaneous detection of 19 drugs of abuse on dried urine spot by liquid chromatography-tandem mass spectrometry. Clin Biochem 46:1118-24, 2013. PubMed PMID: 23583348.
  • Emerson JF, Lai KK. Endogenous Antibody Interferences in Immunoassays. Lab Med 44: 69-73, 2013.
  • Lai KK, Jin M, Yuan S, Larson MF, Dominitz JA, Bankson DD. An improved reflexive testing algorithm for hepatitis C infection utilizing signal-to-cutoff ratios of an anti-HCV antibody assay. Clin Chem 57:1050-6, 2011. PubMed PMID: 21566071. (Key article editorialized by D. Robert Dufour and featured by Clin Chem as Journal Club Article)
  • Lai KK*, Shang S*, Lohia N, Booth GC, Masse DJ, Fausto N, Campbell JS, Beretta L. Extracellular matrix dynamics in hepatocarcinogenesis: a comparative proteomics study of PDGFC transgenic and Pten null mouse models. PLoS Genet 7(6):e1002147, 2011. PubMed PMID: 21731504. (*Equal contribution)
  • Xu J*, Lai KK*, Verlinsky A, Lugea A, French SW, Cooper M, Ji C, Tsukamoto H. Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. J Hepatol 55:673-82, 2011. PubMed PMID:21256905. (*Equal contribution)
  • Lai KK, Kolippakkam D, Beretta L. Comprehensive and quantitative proteome profiling of the mouse liver and plasma. Hepatology 47:1043-51, 2008. PubMed PMID:18266228.
  • Pal S, Sullivan DG, Kim S, Lai KKY, Kae J, Cotler SJ, Carithers Jr RL, Wood BL, Perkins JD, Gretch DR. Productive replication of hepatitis C virus in perihepatic lymph nodes in vivo: implications of HCV lymphotropism. Gastroenterology 130:1107-16, 2006. PubMed PMID:16618405.
  • Lai KK, Cook L, Krantz EM, Corey L, Jerome KR. Calibration curves for real-time PCR. Clin Chem 51:1132-36, 2005. PubMed PMID:15976098.
  • Lai KK, Cook L, Corey L, Jerome KR. Evaluation of real-time PCR versus PCR with liquidphase hybridization for the detection of Enterovirus RNA in cerebrospinal fluid. J Clin Microbiol 41:3133-41, 2003. PubMed Central PMCID: PMC165290.
  • Lai KKY, Chan JLY, Lai KKT, Schmer G, Fritsche TR. Sir Patrick Manson: good medicine for the people of Hong Kong. Hong Kong Med J 9:145-7, 2003. PubMed PMID:12668830.
  • Kurtek RW, Lai KK, Tauxe WN, Eidelman BH, Fung JJ. Technetium-99m hexamethylpropylene amine oxime scintigraphy in the diagnosis of brain death and its implications for the harvesting of organs used for transplantation. Clin Nucl Med 25:7-10, 2000. PubMed PMID:10634522.
  • Kurtek RW, Tauxe WN, Lai KK, Fung JJ. I-131 orthoiodohippurate assessment of renal function after heart transplantation. Clin Nucl Med 24:117-9, 1999. PubMed PMID:9988071.
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