Kevin McDonnell, M.D., Ph.D.
- Medical Oncology
- Cancer Genetics
- Genetic Susceptibility to Cancer
- Mechanism of Cancer Initiation and Progression
- Precision Medicine
- Assistant Professor, Department of Medical Oncology & Therapeutics Research
- Assistant Professor, Center for Precision Medicine
Dr. McDonnell earned his medical and doctoral degrees at Georgetown University. He completed his clinical training at the New York Presbyterian Hospital, Memorial Sloan Kettering Cancer Center and University of Michigan. Dr. McDonnell joined City of Hope following eight years at Keck School of Medicine of USC and USC Norris Comprehensive Cancer Center, where he focused on colon cancer, cancer genetics, functional genomics and personalized cancer medicine.
With numerous research projects and dozens of publications to his credit, Dr. McDonnell is excited to be part of the team at City of Hope, which he calls "a world-class cancer hospital and research institute."
Location
Duarte Cancer Center
Duarte, CA 91010
Education & Experience
2016, Medical Oncology, American Board of Internal Medicine
2014, Internal Medicine, American Board of Internal Medicine
1997, M.D., Ph.D., Medicine/Physiology & Biophysics, Georgetown University, Washington, D.C.
1987, M.A., Philosophy, Kennedy Institute of Ethics, Georgetown University, Washington, D.C.
1987, M.A., English Literature, Georgetown University, Washington, D.C.
1984, B.A., English Literature, Georgetown University, Washington, D.C.
2009-2012, Clinical Fellow, Hematology & Oncology, Department of Medicine, University of Michigan, Ann Arbor, MA
2006-2009, Postdoctoral Fellow, Molecular Cancer Genetics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
1998-2003, Postdoctoral Fellow, Molecular Cancer Genetics, Lombardi Cancer Center, Washington, D.C.
2003-2006, Internal Medicine, New York Presbyterian Hospital, Memorial Sloan Kettering Cancer Center, Hospital for Special Surgery, Weill Cornell Medical Center, New York, NY
1997-1998, Intern, General Surgery, Department of Surgery, Georgetown University, Washington, D.C.
2020-present, Assistant Professor, Center for Precision Medicine
2019-present, Assistant Professor, Department of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA
2017-2020, Assistant Professor, Department of Medicine, Division of Oncology, University of Southern California, Los Angeles, CA
2012-2016, Clinical Instructor, Department of Medicine, Division of Oncology, University of Southern California, Los Angeles, CA
Awards & Memberships
Awards
2012, Young Investigator Award, American Society of Clinical Oncology
2001, Quest Diagnostics Young Investigator Award, The Endocrine Society
2000-2003, First Place, Cancer Center Research Symposium, Lombardi Cancer Center, Georgetown University Medical Center, Washington, D.C.
1998, Second Place, Medical Center Research Symposium, Georgetown University School of Medicine, Washington, D.C.
1997, Ph.D. with Distinction, Department of Physiology, Georgetown University School of Medicine, Washington, D.C.
1997, Lawrence Lillienfield Award In Physiology, Georgetown University School of Medicine, Washington, D.C.
1995, First Place, Bioethics Writing Competition, The Academy of Medicine of Washington, D.C.
Publications
- Ricker C, Culver JO, Lowstuter K, Sturgeon D, Sturgeon JD, Chanock CR, et al. Increased yield of actionable mutations using multi-gene panels to assess hereditary cancer susceptibility in an ethnically diverse clinical cohort. Cancer Genet. 2016;209(4):130-7.
- Scarbrough PM, Weber RP, Iversen ES, et al. A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. Jan 2016;25(1):193-200.
- Schumacher FR, Schmit SL, Jiao S, et al. Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Nat Commun. 2015;6:7138.
- McDonnell KJ, Gallanis GT, Heller KA, et al. A novel BAP1 mutation is associated with melanocytic neoplasms and thyroid cancer. Cancer Genet. Dec 22 2015.
- Davis EJ, Griffith KA, Kim EJ, Ruch JM, McDonnell KJ, Zalupski MM. A Phase II Study of Biweekly Cisplatin, Fixed-Dose-Rate Gemcitabine and Infusional 5-Fluorouracil in Patients With Metastatic Pancreatic and Biliary Cancers. Am J Clin Oncol. Nov 3 2015.
- Ryu S, McDonnell K, Choi H, et al. Suppression of miRNA-708 by polycomb group promotes metastases by calcium-induced cell migration. Cancer Cell. Jan 14 2013;23(1):63-76.
- Ryu S, Joshi N, McDonnell K, et al. Discovery of novel human breast cancer microRNAs from deep sequencing data by analysis of pri-microRNA secondary structures. PLoS One. 2011;6(2):e16403.
- Tassi E, McDonnell K, Gibby KA, et al. Impact of fibroblast growth factor-binding protein-1 expression on angiogenesis and wound healing. Am J Pathol. Nov 2011;179(5):2220-2232.
- McDonnell K, Betz B, Fullen D, Lao CD. V559A and N822I double KIT mutant melanoma with predictable response to imatinib? Pigment Cell Melanoma Res. Apr 2011;24(2):390-392.
- Mellick AS, Plummer PN, Nolan DJ, et al. Using the transcription factor inhibitor of DNA binding 1 to selectively target endothelial progenitor cells offers novel strategies to inhibit tumor angiogenesis and growth. Cancer Res. Sep 15 2010;70(18):7273-7282.
- Janjigian YY, McDonnell K, Kris MG, et al. Pack-years of cigarette smoking as a prognostic factor in patients with stage IIIB/IV nonsmall cell lung cancer. Cancer. Feb 1 2010;116(3):670-675.
- Gao DC, Nolan D, McDonnell K, et al. Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression. Bba-Rev Cancer. Aug 2009;1796(1):33-40.
- Gibby KA, McDonnell K, Schmidt MO, Wellstein A. A distinct role for secreted fibroblast growth factor-binding proteins in development. Proc Natl Acad Sci USA. May 26 2009;106(21):8585-8590.
- Gao D, Nolan DJ, Mellick AS, Bambino K, McDonnell K, Mittal V. Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science. Jan 11 2008;319(5860):195-198.
- Tassi E, McDonnell K, Kim SE, et al. Regulation of blood pressure and vascular tone by an angiogenic modulator, an FGF-binding protein. Hypertension. Oct 2006;48(4):E81-E81.
- Xie B, Tassi E, Swift MR, et al. Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. J Biol Chem. Jan 13 2006;281(2):1137-1144.
- McDonnell K, Bowden ET, Cabal-Manzano R, Hoxter B, Riegel AT, Wellstein A. Vascular leakage in chick embryos after expression of a secreted binding protein for fibroblast growth factors. Lab Invest. Jun 2005;85(6):747-755.
- Tilli MT, Reiter R, Oh AS, et al. Overexpression of an N-terminally truncated isoform of the nuclear receptor coactivator amplified in breast cancer 1 leads to altered proliferation of mammary epithelial cells in transgenic mice. Mol Endocrinol. Mar 2005;19(3):644-656.
- Mulroney SE, Woda CB, Halaihel N, et al. Central control of renal sodium-phosphate (NaPi-2) transporters. Am J Physiol Renal Physiol. Apr 2004;286(4):F647-652.
- Barbey-Morel C, McDonnell K, Pert CB, et al. Peptide T bolus normalizes the growth hormone secretion pattern in two children with AIDS. Peptides. Dec 2002;23(12):2279-2281.
- Powers C, Aigner A, Stoica GE, McDonnell K, Wellstein A. Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth. J Biol Chem. Apr 19 2002;277(16):14153-14158.
- Tassi E, Al-Attar A, Aigner A, et al. Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein. J Biol Chem. Oct 26 2001;276(43):40247-40253.
- Mulroney SE, McDonnell KJ, Pert CB, et al. HIV gp120 inhibits the somatotropic axis: a possible GH-releasing hormone receptor mechanism for the pathogenesis of AIDS wasting. Proc Natl Acad Sci USA. Feb 17 1998;95(4):1927-1932.
- McDonnell KJ, Sculco TP. Dakin's solution revisited. Am J Orthop (Belle Mead NJ). Jul 1997;26(7):471-473.
- Peisen JN, McDonnell KJ, Mulroney SE, Lumpkin MD. Endotoxin-induced suppression of the somatotropic axis is mediated by interleukin-1 beta and corticotropin-releasing factor in the juvenile rat. Endocrinology. Aug 1995;136(8):3378-3390.