Breast Cancer Care in Orange County
Many breakthrough treatments offer new hope for today’s breast cancer patients. You can access this level of world-class care in Orange County. Our top-ranked breast cancer physicians and other specialists help those with breast cancer navigate and manage their care, from diagnosis to treatment and transition to recovery.
Why Choose City of Hope Orange County for Breast Cancer Care?
With leading-edge technology and surgical expertise, City of Hope breast cancer specialists deliver outstanding outcomes that are difficult to achieve elsewhere.
- A track record of exceptional breast cancer survival outcomes for patients at all stages.
- Advanced techniques such as nipple-sparing mastectomies, high-precision radiation and immunotherapies.
- A comprehensive, supportive care program to address a wide range of cancer and treatment-related concerns from diagnosis to remission and beyond.
- A collaborative and caring multidisciplinary team of breast cancer experts that understands your needs and background to provide a whole-person approach to treatment.
- Access to promising new therapies through more than 100 innovative, ongoing research and clinical trials for breast cancer.
- Long-term survivorship and follow-up programs focused on minimizing recurrence risk and improving quality of life.
- An expanding clinical network throughout Orange County is bringing world-renowned physicians closer to homes in the region.
Clinical trial participation is a critical aspect of care for many patients living with cancer. Our patients can access more than 1,000 innovative Phase 1–3 clinical trials at City of Hope each year — more cancer-focused clinical trials than anywhere in the area — to provide promising new treatments long before they become the standard of care.

We Specialize in State-of-the-Art Treatments for Breast Cancer
Our advanced cancer treatments and screenings include:
- Targeted therapy for breast cancer that selectively attacks cancer cells based on specific characteristics
- Novel therapies, many of which have been discovered or developed at City of Hope®, and the identification and monitoring of tumor markers to inform changes in treatment over time
- Endocrine (hormone) therapy to decrease the production of cancer-fueling hormones to prevent, slow or stop cancer
- Breast-conserving surgery that removes early-stage tumors while delivering excellent cosmetic outcomes
- Skin and nipple-sparing mastectomies with breast reconstruction in one procedure (and a multicenter national clinical trial evaluating robotic surgery for mastectomies)
- Direct-to-implant postmastectomy breast reconstruction surgery that is performed without the use of tissue expanders.
- Complex, autologous tissue-based (flap) reconstructions
- 3D Mammogram to better detect and locate breast cancer
- Magnetic resonance imaging and ultrasound for people with dense breasts or high breast cancer risk
- High-Risk Breast Clinic at City of Hope Orange County Lennar Foundation Cancer Center, where adults with a familial history of breast cancer can meet with a compassionate team of experts to determine their best options for surveillance and risk reduction
- A clinical trial through City of Hope Precision Medicine that offers free germline panel testing to assess a women’s genetic risk for breast and other cancers
- Oncoplastic surgery
Where you get a mammorgram matters.
City of Hope Orange County offers the most advanced mammography technology available.
Regular screening is one of the best ways to find breast cancer early. Early detection can make treatment easier and more effective.

A trailblazing integrative medicine program combining the best of Western medicine and evidence-based complementary therapies, such as acupuncture, massage and meditation.
City of Hope is a national leader in evidence-based supportive care. The Sheri & Les Biller Patient and Family Resource Center at the Lennar Foundation Cancer Center will facilitate easy access to a wide range of programs, including care navigation, survivorship programs, psychological and spiritual counseling, pain management and more.
Marybelle's is a full-service salon extending a specialty shopping experience with oncology-trained cosmetologists.
The on-site pharmacy fills and dispenses prescriptions and offers over-the-counter medications, alleviating the burden of going elsewhere.
A Grateful Patient Story
City of Hope Orange County Breast Cancer Doctors
City of Hope Orange County has a team of cancer specialists who are known for their expertise in breast cancer prevention, detection, and treatment.
Breast Cancer Leadership


Double board-certified surgical oncologist Jennifer Tseng, M.D., F.A.C.S., is a breast surgeon in Orange County, California who firmly believes in shared decision-making between physicians and patients.


Irene M. Kang, M.D., is medical director of women’s health medical oncology and an assistant professor in the Department of Medical Oncology & Therapeutics Research, where she specializes in breast cancer.
Radiation Oncology


Radiation oncologist Amanda Schwer, M.D. knew she wanted to be a cancer doctor for as long as she can remember, inspired by the doctors who cured a sibling who faced aggressive disease in early childhood.
Surgical Oncology


Radiation oncologist Amanda Schwer, M.D. knew she wanted to be a cancer doctor for as long as she can remember, inspired by the doctors who cured a sibling who faced aggressive disease in early childhood.


I am passionate about truly understanding my patients, characterizing their disease, identifying the best strategy, and then providing the most appropriate, personalized care for each individual patient.
Plastics & Reconstructive Surgery


Plastic surgeon Mouchammed Agko, M.D., understands that many cancer survivors want to continue their lives after treatment without physical reminders of the disease. His goal is to help them achieve that — as well as additional aesthetic improvements if it meets a patient’s needs.
Medical Oncology


Wade Michael Smith, M.D., brings his expertise and training in a variety of cancers to City of Hope | Newport Beach in his role as an oncologist and assistant clinical professor in the Department of Medical Oncology & Therapeutics Research.


Fluent in Mandarin, Luke Chen, M.D., has helped cancer patients in Southern California for nearly 20 years. Focused on both saving life and improving quality of life, he treats his patients as family and is inspired by their courage and humility.


Medical oncologist and hematologist Sudarsan Vishnu Kollimuttathuillam, M.D., is determined to deliver patient-centered care by understanding each individual’s unique needs. He gives his all for patients, and receives so much in return; they inspire him to work harder and become a better human being.


Danny Nguyen, M.D., believes that the start of great cancer care involves the patient. Answering their important questions fully is one of his favorite challenges in his work. He also believes that collaborating closely with other physicians is important for forming the best team for each patient.


Karla Olmedo, M.D., is a rising star in hematology/oncology. The co-author of clinical research studies and review articles published in the Journal of Emergency Medicine, Blood, and Rutgers University Press, she now contributes to the distinguished bench of expertise at City of Hope Orange County Lennar Foundation Cancer Center.


At a very young age, Dr. Krushangi Patel was inspired by a compassionate and highly skilled physician who supported her family through their medical crisis. This experience shaped her into a highly engaged practitioner who prioritizes not only her patients' physical well-being but also their emotional and spiritual needs.


George Bernard Semeniuk, III, M.D., was drawn to cancer care while in medical school, after a young family member died of brain cancer.


Tingting Tan, M.D., Ph.D., is internationally renowned for studying the molecular signaling pathways in tumor development and the mechanisms of chemotherapy resistance. She is board certified in medical oncology, hematology, and internal medicine.


Personal experience inspired Lihong Wu, M.D., to pursue her career as a physician. The daughter of a doctor, she would shadow her father at work and be amazed at the care he provided.
Supportive Care


Richard T. Lee, M.D., is a third-generation physician who was inspired by seeing the positive impact that good health care can have on a community. His philosophy as an oncologist is all about treating the whole patient — centering care on who they are and what they need.


Jessica Cheng, M.D., is among the nation’s few, and Orange County’s only, fellowship-trained experts in cancer rehabilitation medicine. This is a subspecialty of physical medicine and rehabilitation (PM&R) also known as physiatry.