An NCI-designated Comprehensive Cancer Center
Stephen Gruber

Stephen Gruber, M.D., M.P.H., Ph.D.

Director of the Center for Precision Medicine; Medical Oncologist
Clinical Expertise
  • Medical Oncology
  • Epidemiology
Research Focus
  • Precision Medicine
  • Genomics of Cancer
Contact
Email: [email protected]

Clinical Teams

  • Medical Oncology & Therapeutics Research
A world-renowned cancer geneticist, Stephen Gruber, M.D., Ph.D., M.P.H. focuses his research on precision medicine and the genomics of cancer in order to improve treatment and care for cancer patients and their families. His particular research interests include the genetic epidemiology of cancer, with an emphasis on solid tumors, bringing clinical cancer genetics and translational research to cancer prevention.
 
Dr. Gruber joins us from USC Norris Cancer Hospital, where he served as the director of the National Cancer Institute-designated USC  Norris Comprehensive Cancer Center, and Keck Hospital of USC, where he held positions as attending physician and board member, professor of medicine and professor of preventive medicine at the Keck School of Medicine of USC. Dr. Gruber held the Jane & Kris Popovich Chair of Cancer Research endowed chair at USC. He will be bringing members of his team from USC Norris Cancer Hospital to assist in his efforts to use genetics and genomics to drive preventive medicine, population health, clinical medicine, health outcomes and translational innovation.
 
Dr. Gruber is both a medical oncologist and epidemiologist, and he earned his master of public health and Ph.D. in epidemiology from Yale University. He earned his medical degree from University of Pennsylvania Medical School and completed fellowships in medical oncology at Johns Hopkins Hospital and in clinical medical genetics at University of Michigan.
 
Dr. Gruber has been continuously funded by the National Institutes of Health since 1998 and is an elected member of the American Society of Clinical Investigation.

Locations

City of Hope Comprehensive Cancer Center, 1500 East Duarte Road

Duarte, CA 91010

McDonnell KJ, Chemler JA, Bartels PL, O’Brien E, Marvin ML, Ortega J, Stern RH, Raskin L, Li G-M, Sherman DH, Barton JK, Gruber SB. A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S]2+ cluster. Nature Chemistry 2018, Jun 18 [Epub ahead of print] PMID: 29915346

Schmit SL, Edlund CK, Schumacher FR, Gong J, Harrison TA, Huyghe JR, Qu C, Melas M, Van Den Berg DJ, Wang H, Tring S, Plummer SJ, Albanes D, Alonso MH, Amos CI, Anton K, Aragaki AK, Arndt V, Barry EL, Berndt SI, Bezieau S, Bien S, Bloomer A, Boehm J, Boutron-Ruault MC, Brenner H, Brezina S, Buchanan DD, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Castelao JE, Chan AT, Chang-Claude J, Chanock SJ, Cheng I, Cheng YW, Chin LS, Church JM, Church T, Coetzee GA, Cotterchio M, Cruz Correa M, Curtis KR, Duggan D, Easton DF, English D, Feskens EJM, Fischer R, FitzGerald LM, Fortini BK, Fritsche LG, Fuchs CS, Gago-Dominguez M, Gala M, Gallinger SJ, Gauderman WJ, Giles GG, Giovannucci EL, Gogarten SM, Gonzalez-Villalpando C, Gonzalez-Villalpando EM, Grady WM, Greenson JK, Gsur A, Gunter M, Haiman CA, Hampe J, Harlid S, Harju JF, Hayes RB, Hofer P, Hoffmeister M, Hopper JL, Huang SC, Huerta JM, Hudson TJ, Hunter DJ, Idos GE, Iwasaki M, Jackson RD, Jacobs EJ, Jee SH, Jenkins MA, Jia WH, Jiao S, Joshi AD, Kolonel LN, Kono S, Kooperberg C, Krogh V, Kuehn T, Küry S, LaCroix A, Laurie CA, Lejbkowicz F, Lemire M, Lenz HJ, Levine D, Li CI, Li L, Lieb W, Lin Y, Lindor NM, Liu YR, Loupakis F, Lu Y, Luh F, Ma J, Mancao C, Manion FJ, Markowitz SD, Martin V, Matsuda K, Matsuo K, McDonnell KJ, McNeil CE, Milne R, Molina AJ, Mukherjee B, Murphy N, Newcomb PA, Offit K, Omichessan H, Palli D, Cotoré JPP, Pérez-Mayoral J, Pharoah PD, Potter JD, Qu C, Raskin L, Rennert G, Rennert HS, Riggs BM, Schafmayer C, Schoen RE, Sellers TA, Seminara D, Severi G, Shi W, Shibata D, Shu XO, Siegel EM, Slattery ML, Southey M, Stadler ZK, Stern MC, Stintzing S, Taverna D, Thibodeau SN, Thomas DC, Trichopoulou A, Tsugane S, Ulrich CM, van Duijnhoven FJB, van Guelpan B, Vijai J, Virtamo J, Weinstein SJ, White E, Win AK, Wolk A, Woods M, Wu AH, Wu K, Xiang YB, Yen Y, Zanke BW, Zeng YX, Zhang B, Zubair N, Kweon SS, Figueiredo JC, Zheng W, Marchand LL, Lindblom A, Moreno V, Peters U, Casey G, Hsu L, Conti DV, Gruber SB. Novel Common Susceptibility Loci for Colorectal Cancer. J Natl Cancer Inst. 2018 Jun 16 [Epub ahead of print] PMID: 29917119

Hutchenreuther J, Vincent K, Norley C, Racanelli M, Gruber SB, Johnson TM, Fullen DR, Raskin L, Perbal B, Holdsworth DW, Postovit LM, Leask A. Activation of cancer-associated fibroblasts is required for tumor neovascularization in a murine model of melanoma. Matrix Biol. 2018. Jun 6, 2018 [Epub ahead of print] PMID: 298854661

Neumeyer S, Banbury BL, Arndt V, Berndt SI, Bezieau S, Bien SA, Buchanan DD, Butterbach K, Caan BJ, Campbell PT, Casey G, Chan AT, Chanock SJ, Dai JY, Gallinger S, Giovannucci EL, Giles GG, Grady WM, Hampe J, Hoffmeister M, Hopper JL, Hsu L, Jenkins MA, Joshi A, Larsson SC, Le Marchand L, Lindblom A, Moreno V, Lemire M, Li L, Lin Y, Offit K, Newcomb PA, Pharaoh PD, Potter JD, Qi L, Rennert G, Schafmayer C, Schoen RE, Slattery ML, Song M, Ulrich CM, Win AK, White E, Wolk A, Woods MO, Wu AH, Gruber SB, Brenner H, Peters U, Chang-Claude J. Mendelian randomization study of age at menarche and age at menopause and the risk of colorectal cancer. Br J Cancer. 2018 May 24. DOI: 10.1038/s41416-018-0108-8. [Epub ahead of print] PMID: 29795306

Fritsche LG, Gruber SB, Wu Z, Schmidt EM, Zawistowski M, Moser SE, Blanc VM, Brummett CM, Kheterpal S, Abecasis GR, Mukherjee B. Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from the Michigan Genomics Initiative.  Am J Hum Genet. 2018 May 17. pii: S0002-9297(18)30133-2, PMID: 29779563

Thomas NE, Edmiston SN, Orlow I, Kanetsky PA, Luo L, Gibbs DC, Parrish EA, Hao H, Busam KJ, Armstrong BK, Kricker A, Cust AE, Anton-Culver H, Gruber SB, Gallagher RP, Zanetti R, Rosso S, Sacchetto L, Dwyer T, Ollila DW, Begg CB, Berwick M, Conway K; GEM Study Group. Inherited Genetic Vriants Associated with melanoma BRAF/NRAS Subtypes. J Invest Dermatol. 2018 May 9. pii: S0022-202X(18)31962-6, PMID: 29753029

Jeon J, Du M, Schoen RE, Hoffmeister M, Newcomb PA, Berndt SI, Caan B, Campbell PT, Chan AT, Chang-Claude J, Giles GG, Gong J, Harrison TA, Huyghe JR, Jacobs EJ, Li L, Lin Y, Le Marchand L, Potter JD, Qu C, Bien SA, Zubair N, Macinnis RJ, Buchanan DD, Hopper JL, Cao Y, Nishihara R, Rennert G, Slattery ML, Thomas DC, Woods MO, Prentice RL, Gruber SB, Zheng Y, Brenner H, Hayes RB, White E, Peters U, Hsu L; Colorectal Transdisciplinary Study and Genetics and Epidemiology of Colorectal Cancer Consortium. Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic Factors. Gastroenterology. 2018 Jun;154(8):2152-2164. PMID:29458155

Ricker CN, Koff RB, Qu C, Culver J, Sturgeon D, Kingham KE, Lowstuter K, Chun NM, Rowe-Teeter C, Lebensohn A, Levonian P, Partynski K, Lara-Otero K, Hong C, Petrovchich IM, Mills MA, Hartman AR, Allen B, Ladabaum U, McDonnell K, Ford JM, Gruber SB, Kurian AW, Idos GE. Patient communication of cancer genetic test results in a diverse population. Transl Behav Med. 2018 Jan 29;8(1):85-94 PMID: 29385580
Saliba W, Rennert HS, Gronich N, Gruber SB, Rennert G. Association of Atrial Fibrillation and Cancer: Analyis from two large population-based case-control studies. PLoS One 2018. 1;13(1):e0190324 PMID: 29324747, PMCID:5764256

Raskin L, Guo Y, Du L, Clendenning M, Rosty C; Colon Cancer Family Registry (CCFR), Lindor NM, Gruber SB, Buchanan DD. Targeted sequencing of established and candidate colorectal cancer genes in the Colon Cancer Family Registry Cohort. Oncotarget. 2017 Jun 21;8(55):93450-93463. PMID: 29212164, PMCID: PMC5706810

Stoffel EM, Koeppe E, Everett J, Ulintz P, Kiel M, Osborne J, Williams L, Hanson K, Gruber SB, Rozek LS. Gastroenterology. 2017 Nov 12. pii: S0016-5085(17)36350-3  [Epub ahead of print] PMID: 29146522
Hung RJ, Fehringer G, Casey G, Gruber SB, Peters U, Goode EL, Sellers TA, Haiman CA, Hunter DJ, Kraft P, Amos CI, Freedman ML, Wilson MD. Cross-Cancer Analysis Reveals Novel Pleiotropic Associations-Response. Cancer Res. 2017 Nov 1;77(21):6045-6046, 2017 PMID: 29066515

Orlow I, Shi Y, Kanetsky PA, Thomas NE, Luo L, Corrales-Guerrero S, Cust AE, Sacchetto L, Zanetti R, Rosso S, Armstrong BK, Dwyer T, Venn A, Gallagher RP, Gruber SB, Marrett LD, Anton-Culver H, Busam K, Begg CB, Berwick M; GEM Study Group. The inetration between vitamin D receptor polymorphisms and sun expsorue round time of diagnosis influences melanoma survival. Pigment Cell Melanoma Res. 2017 Oct 9 PMID: 28990310

Thomas NE, Edmiston SN, Kanetsky PA, Busam KJ, Kricker A, Armstrong BK, Cust AE, Anton-Culver H, Gruber SB, Luo L, Orlow I, Reiner AS, Gallagher RP, Zanetti R, Rosso S, Sacchetto L, Dwyer T, Parrish EA, Hao H, Gibbs DC, Frank JS, Ollila DW, Begg CB, Berwick M, Conway K; GEM Study Group. Associations of MC1R Genotype and Patient Phenotypes with BRAF and NRAS Mutations in Melanoma.  J Invest Dermatol. 2017 Dec;137(12):2588-2598, 2017 PMID: 28842324
In The News
An Expert's Voice
Microbes in Space | City of Hope

Cancer care predictions 2020:
The best is yet to come