Maria Hahn, Ph.D.

626-256-4673
Maria Hahn, Ph.D.
Associate Research Professor, Department of Surgery
Research Area
  • Epigenetics
  • Genomics
  • Cancer Biology
Research Teams
Surgery Research
Molecular and Cellular Biology
Gene Surgery

 

Location

Education & Experience

Publications

  • Hahn M.A., Jin S.G., Li A.X., Liu J., Huang Z., Wu X., Kim B.W., Johnson J., Bilbao A.V., Tao S., Yim J.A., Fong Y., Goebbels S., Schwab M.H., Lu Q., Pfeifer G.P. (2019). Reprogramming of DNA methylation at NEUROD2-bound sequences during cortical neuron differentiation.  Sci Adv. 2019 Oct 23;5(10):eaax0080.
  • Yim J.H., Choi A.H., Li A.X., Qin H., Chang S., Tong S.T., Chu P., Kim B.W., Schmolze D., Lew R., Ibrahim Y., Poroyko V.A., Salvatierra S., Baker A., Wang J., Wu X., Pfeifer G.P., Fong Y., Hahn M.A. (2019). Identification of Tissue-Specific DNA Methylation Signatures for Thyroid Nodule Diagnostics. Clin Cancer Res. 2019 Jan 15;25(2):544-551.
  • Hanley M.P., Hahn M.A., Li A.X., Wu X., Lin J., Wang J., Choi A.H., Ouyang Z., Fong Y., Pfeifer G.P., Devers T.J., Rosenberg D.W. (2017). Genome-wide DNA methylation profiling reveals cancer-associated changes within early colonic neoplasia. Oncogene. 2017 Aug 31;36(35):5035-5044
  • Hahn M.A., Li A.X., Wu X., Yang R., Drew D.A., Rosenberg D.W., and Pfeifer G.P. (2014). Loss of the Polycomb mark from bivalent promoters leads to activation of cancer-promoting genes in colorectal tumors. Cancer Res. 2014 Jul 1;74(13):3617-29.
  • Hahn M.A., Qiu R., Wu X., Li A.X., Wang J., Zhang J., Jui J., Jin S.G., Jiang Y., Pfeifer G.P. and  Lu Q. (2013). Dynamics of 5-hydroxymethylcytosine and chromatin marks in mammalian neurogenesis. Cell Reports 3, 291-300, February 21, 2013 
  • Lahtz C., Bates S.E., Jiang Y., Li A.X., Wu X., Hahn M.A., Pfeifer G.P. (2012). Gamma irradiation does not induce detectable changes in DNA methylation directly following exposure of human cells PLoS One. 2012;7(9):e44858. Epub 2012 Sep 14. 
  • Kim B.W., Esworthy R.S., Hahn M.A., Pfeifer G.P. and Chu F.F. (2011). Expression of lactoperoxidase in mouse intestinal epithelial cells. Free Radic Biol Med. 52, 1569-1576, 2012 Feb 14.
  • Hahn M.A, Wu X., Li A.X., Hahn T., and Pfeifer G.P. (2011). Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks. PLoS One. 2011 Apr 19;6(4):e18844.
  • Hahn MA, Hahn T, Lee DH, Esworthy RS, Kim BW, Riggs AD, Chu FF, Pfeifer GP. (2008) Methylation of Polycomb target genes in intestinal cancer is mediated by inflammation. Cancer Res. 2008 Dec 15; 68(24):10280-9.
  • Dammann R., Strunnikova M., Schagdarsurengin U., Rastetter M., Papritz M., Hofman S., Silber R., Burdach S. and Hansen G. (2005) Aberrant methylation and expression of tumor associated genes in lung carcinoma. Eur. J Cancer. May; 41(8):1223-36
  • Strunnikova M., Schagdarsurengin U., Kehlen A., Garbe J.C., Stampfer M.R. and Dammann R. (2005) Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter. Mol Cell Biol. May; 25(10):3923-33. 
  • Kisliakova TV, Kustova ME, Lianguzova MS, Malashcheva AB, Strunnikova MA, Suchkova IO, Pospelov VA, Patkin EL. (2000) Non induced single strand DNA breaks in F9 teratocarcinoma cells of mouse. Tsitologiia 42(11):1060-8 (In Russian).
Reviews and Book Chapters
  • Hahn M.A., Szabo P.E. and Pfeifer G.P. (2014). 5hmC: stable or transient mark? (2014). Genomics. 2014 Nov;104(5):314-23.
  • Hahn M.A. and Pfeifer G.P. (2014). Single base resolution analysis of 5-methylcytosine and 5-hydroxymethylcytosine by RRBS and TAB-RRBS. Methods Mol Biol. 2015; 1238:273-87. 
  • Pfeifer G.P., Xiong W., Hahn M.A., Jin S.J.(2014).  The role of 5-hydroxymethylcytosine in human cancer. Cell & Tissue Research. Cell Tissue Res. 2014 Jun;356(3):631-41
  • Hahn MA, Pfeifer GP. (2009) Methods for genome-wide analysis of DNA methylation in intestinal tumors. Mutat Res. 2009 Oct 23.
  • Dammann R., Schagdarsurengin U., Seidel C., Strunnikova M., Rastetter M., Baier K,. Pfeifer G.P. (2005) The tumor suppressor RASSF1A in human carcinogenesis: an update. Histol Histopathol. Apr; 20 (2) 645-663.
  • Dammann R, Schagdarsurengin U, Strunnikova M, Rastetter M, Seidel C, Liu L, Tommasi S, Pfeifer GP.(2003) Epigenetic inactivation of the Ras-association domain family 1 (RASSF1A) gene and its function in human carcinogenesis. Histol Histopathol. Apr; 18 (2):665-77.