An NCI-designated Comprehensive Cancer Center
Systems Biology - Rui Su

Rui Su, Ph.D.

Assistant Research Professor, Department of Systems Biology
Research Focus
  • Gene region specific N6-methyladenosine (m6A) modification at global mRNA level
  • Development of small molecules targeting m6A regulators for leukemia therapy
  • Identification of novel mechanisms participating immune checkpoint blockade therapy
Contact
Email: [email protected]

Research Teams

  • Systems Biology
  • Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Wang Y, Weng X, Hu C, Yu M, Strong J, Dai Q, Zou D, Qing Y, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki AT, Plas D, Bradner JE, Wei M, Marcucci G,  Jiang X, Mulloy J, Jin J, He C, Chen J. R-2HG exhibits anti-tumor activity by targeting FTO/MYC signaling. Cell, 2018 Jan 11;172(1-2):90-105.e23.
  • Deng X, Su R, Stanford S, Chen J. Critical enzymatic functions of FTO inobesity and cancer. Front Endocrinol (Lausanne). 2018, 9:396. DOI: 10.3389/fendo.2018.00396.
  • Deng X, Su R, Huang H, Weng H, Li Z, Chen J. RNA N6-methyladenosine in cancers: current status and perspectives. Cell Research. 2018, 28(5):507-517.
  • Deng X, Su R, Feng X, Wei M, Chen J. Role of N6-methyladenosine modification in cancer. Curr Opin Genet Dev. 2017, 48:1-7.
  • Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu Y-C, Hüttelmaier S, Skibbe JR, Su R, Deng X, Dong L, Sun M, Li C, Nachtergaele S, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X, Wei M, Qu L, Guan J-L, He C, Yang J, Chen J. Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol. 2018 Mar;20(3):285-295
  • Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich, Zhang, Dore LC, Su R, Deng X, Ferchen K, Li C, Sun M, Lu Z, Jiang X, Marcucci G, Mulloy JC, Yang J, Qian Z, Wei M, He C, Chen J. METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification. Cell Stem Cell. 2018 Feb 1;22(2):191-205.e9
  • Li Z*, Weng H*, Su R*, Weng X*, Zuo Z*, Li C, Huang H, Hu C, Qin X, Tang L, Wang Y, Hong G-M, Huang H, Wang X, Chen P, Gurbuxani S, Arnovitz S, Li Y, Li S, Strong J, Neilly MB, Larson RA, Le Beau MM, Jiang X, Zhang P, Jin J, He C, Chen J. FTO plays an oncogenic role in acute myeloid leukemia as a N6-methyladenosine RNA demethylase. Cancer Cell, 2017 Jan 9;31(1):127-141. (*co-first author)
  • Jiang X, Hu C, Ferchen K, Nie J, Cui X, Chen C-H, Cheng L, Zuo Z, Seibel W, He C, Tang Y, Skibbe JR, Wunderlich M, Reinhold WC, Dong L, Shen C, Arnovitz S, Ulrich B, Lu J , Weng H, Su R, Huang H, Wang Y, Li C, Qin X, Mulloy JC, Zheng Y, Diao J, Jin J, Li C, Liu PP, He C, Chen Y, Chen J. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099.
  • Wang F, Song W, Zhao H, Ma Y, Li Y, Zhai D, Pi J, Si Y, Xu J, Dong L, Su R, Zhang M, Yong Zhu Y, Ren X, Miao F, Liu W, Li F, Zhang J, He A, Shan G, Hui J, Wang L, Yu J. The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis. Cell Research. 2017 Mar;27(3):416-439
  • Song L, Lin H-S, Gong J-N, Han H, Wang X-S, Su R, Chen M-T, Shen C, Ma Y-N, Yu Y, Zhang J-W. microRNA-451-modulated hnRNP A1 takes a part in granulocytic differentiation regulation and acute myeloid leukemia. Oncotarget. 2017 Jul 18. doi: 10.18632/oncotarget.19325.
  • Shen C, Chen M-T, Zhang X-H, Yin X-L, Ning H-M, Su R, Lin H-S, Song L, Wang F, Ma Y-N, Zhao H-L, Yu J, Zhang J-W. The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia. PLoS Genet. 2016 Sep 12;12(9):e1006259. 
  • Su R, Gong J-N, Song L, Chen M-T, Shen C, Zhang X-H, Yin X-L, Ning H-M, Liu B, Wang F, Ma Y-N, Zhao H-L, Yu J, Zhang J-W. Overexpression of c-Myc recruits HDAC3 to epigenetically suppress miR-451 and further activates YWHAZ/AKT axis in acute myeloid leukemia. Oncotarget. 2016 Nov 22;7(47):77430-77443.
  • Li Z*, Chen P*, Su R*, Hu C*, Li Y,  Elkahloun AG, Zuo Z, Gurbuxani S, Arnovitz S, Weng H, Wang Y, Li S , Huang H, Neilly MB, Wang GG, Jiang X, Liu PP, Jin J, Chen J. PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease. Cancer Res. 2016 Feb 1;76(3):619-29. (*co-first author)
  • Su R#, Dong L, Zou D, Zhao H, Yi R, Li F, Yi P, Li L, Zhu Y, Ma Y, Wang F, Yu J#. microRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia. Oncogene. 2016 Apr 18. doi: 10.1038/onc.2016.127. (#co-senior author)
  • Yin* H, Song* P, Su R*, Yang G, Dong L, Luo M, Wang B, Gong B, Liu C, Song W, Wang F, Ma Y, Zhang J, Wang W, Yu J. DNA Methylation mediated down-regulating of microRNA-33b and its role in gastric cancer. Sci Rep. 2016 Jan 5;6:18824. (*co-first author)
  • Su R, Lin H, Zhang X, Yin X, Ning H, Liu B, Pengfei P, Gong J, Shen C, Song L, Chen J, Wang F, Zhao H, Ma Y, Yu J, Zhang J. MiR-181 family: the regulators of myeloid differentiation and acute myeloid leukemia as well as potentially therapeutic targets. Oncogene. 2015 Jun;34(25):3226-39.
  • Li Z*, Chen P*, Su R*, Li Y, Hu C, Wang Y, Arnovitz S, He M, Gurbuxani S, Zuo Z, Elkahloun AG, Li S, Weng H, Huang H, Neilly MB, Wang S, Olson EN, Larson RA, Le Beau MM, Zhang J, Jiang X, Wei M, Jin J, P. Liu PP, Chen J. Overexpression and knockout of miR-126 both promote leukemogenesis through targeting distinct gene signaling. Blood. 2015 Oct 22;126(17):2005-15. (*co-first author)
  • Chen M-T, Dong L, Zhang X-H, Yin X-L, Ning H-M, Shen C, Su R, Li F, Li L, Ma Y-N, Wang F, Zhao H-L, Yu J, Zhang J-W. ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK6. Sci Rep. 2015 Nov 6;5:16229.
  • Wang Y, Liu C, Luo M, Zhang Z, Gong J, Li J, You L, Dong L, Su R, Lin H, Ma Y, Wang F, Wang Y, ie Chen J, Zhang J, Jia H, Kong Y, Yu J. Chemotherapy-Induced miRNA-29c/Catenin-δ Signaling Suppresses Metastasis in Gastric Cancer. Cancer Res. 2015 Apr 1;75(7): 1332-44
  • Zhai P-F, Wang F, Su R, Lin H-S, Jiang C-L, Yang G-H, Yu J, Zhang J-W. The regulatory roles of microRNA-146b-5p and its target platelet-derived growth factor receptor α (PDGFRA) in erythropoiesis and megakaryocytopoiesis. J Biol Chem. 2014 Aug 15;289(33):22600-13.
  • Lin H-S, Gong J-N, Su R, Chen M-T, Song L, Shen C, Wang F, Ma Y-N, Zhao H-L, Yu J, Li W-W, Huang L-X, Xu X-H, Zhang J-W. MiR-199a-5p inhibits monocyte/macrophage differentiation by targeting the activin A type 1B receptor gene and finally reducing C/EBPα level. J Leukoc Biol. 2014 Dec;96(6):1023-35.
  • Chen J, Li X-B, Su R, Song L, Wang F, Zhang J-W. ZNF16 (HZF1) promotes erythropoiesis and megakaryocytopoiesis via its regulation on JPO2 and c-KIT. Biochem J. 2014 Feb 15; 458(1):171-83.
  • Gong J-N, Yu J, Lin H-S, Zhang X-H, Yin X-L, Xiao Z, Wang F, Wang X-S, Su R, Shen C, Zhao H-L, Ma Y-N, Zhang J-W. The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia. Cell Death Differ. 2014 Jan;21(1):100-12.
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