Xiaolan Deng, Ph.D,

xideng@coh.org
626-218-5628
Xiaolan Deng
Associate Research Professor, Department of Systems Biology
Research Area
New Cancer Therapy Targeting Methyltransferase
Role of M6A Modification in Acute Myeloid Leukemia
Research Teams
Systems Biology
Education & Experience
Degrees

  • 2013, Ph.D., Pharmaceutical Sciences, University of KU Leuven, Belgium

  • 2010, M.S., Pharmaceutical Sciences, University of KU Leuven, Belgium

  • 2008, B.S., Pharmaceutical Sciences, Shenyang Pharmaceutical University, China

Professional Experience

  • 2020-present, Assistant Research Professor, Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA

  • 2018-2020, Staff Scientist, Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA

  • 2017-2018, Postdoctoral Fellow, Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA

  • 2016-2017, Postdoctoral Fellow, Department of Cancer Biology, University of Cincinnati, Cincinnati, OH

  • 2014-2016, Postdoctoral Fellow, Department of Medicine, University of Chicago, Chicago, IL

Publications
  • Li, W., Deng, X., & Chen, J.* RNA-binding Proteins in Regulating mRNA Stability and Translation: Roles and Mechanisms in Cancer. Seminars in Cancer Biology. 2022 Apr 2:S1044-579X(22)00082-7. doi: 10.1016/j.semcancer.2022.03.025.
  • Shen, C., Wang, K., Deng, X.*, & Chen, J.* DNA N(6)-methyldeoxyadenosine in mammals and human diseases. Trends Genet. 2022 Jan 3;S0168-9525(21)00353-X. doi: 10.1016/j.tig.2021.12.003.
  • Su, R., Dong, L., Li, Y., Gao, M., Han, L., Wunderlich, M., Deng, X., Li, H., Huang, Y., Gao, L., Li, C., Zhao, Z., Robison, S., Tan, B., Qing, Y., Qin, X., Prince, E., Xie, J., Qin, H., Li, W., Shen, C., Sun, J., Prakash, K., Weng, H., Huang, H., Chen, Z., Zhang, B., Wu, X., Olsen, M.J., Müschen, M., Marcucci, G., Ravi, S., Li, L., Fathi, A.T., Li, Z., Mulloy, J.C., Wei, M., Horne, D., & Chen, J.* Targeting FTO suppresses cancer stem cell maintenance and immune evasion. Cancer Cell. 2020 Jul 13;38(1):79-96. PMCID: PMC7363590.
  • Shen, C., Sheng, Y., Zhu, A., Robinson, S., Jiang, X., Dong, L., Chen, H., Su, R., Yin, Z., Li, W., Deng, X., Chen, Y., Hu, Y.C., Weng, H., Huang, H., Prince, E., Cogle, C.R., Sun, M., Zhang, B., Chen, C.W., Marcucci, G., He, C.*, Qian, Z.*, Chen, & J.* RNA demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia. Cell Stem Cell. 2020 Jul 2;27(1):64-80. PMCID: PMC7335338.
  • Huang, H., Weng, H., Deng, X., & Chen, J.* RNA Modifications in Cancer: Functions, Mechanisms and Therapeutic Implications. Annual Review of Cancer Biology. 2020; 4:221-240.
  • Li, C., Dong, L., Su, R., Bi, Y., Qing, Y., Deng, X., Zhou, Y., Hu, C., Yu, M., Huang, H., Jiang, X., Li, X., He, X., Zou, D., Shen, C., Han, L., Sun, M., Skibbe, J., Ferchen, K., Qin, X., Weng, H., Huang, H., Song, C., Chen, J.* & Jin, J.* Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC. Haematologica. 2019, DOI: 10.3324/haematol.2018.208835.
  • Huang, H., Weng, H., Zhou, K., Wu, T., Zhao, B.S., Sun, M., Chen, Z., Deng, X., Xiao, G., Auer, F., Klemm, L., Wu, H., Zuo, Z., Qin, X., Dong, Y., Zhou, Y., Qin, H., Tao, S., Du, J., Liu, J., Lu, Z., Yin, H., Mesquita, A., Yuan, C.L., Hu, Y.C., Sun, W., Su, R., Dong, L., Shen, C., Li, C., Qing, Y., Jiang, X., Wu, X., Sun, M., Guan, J.L., Qu, L., Wei, M., Müschen, M., Huang, G., He, C., Yang, J., & Chen, J. Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally. Nature. 2019, 567:414-419.
  • Deng, X., Su, R., Stanford, S., & Chen, J.* Critical enzymatic Functions of FTO in Obesity and Cancer. Front Endocrinol. 2018, 9:396-403.
  • Deng, X.*, Su, R., Huang, H., Weng, H., Li, Z., & Chen, J.* N6-methyladenosine in Cancers: Function, Mechanism and Therapeutic Implication. Cell Research. 2018, 28(5): 507-517.
  • Deng, X.*, Su, R., Feng, X., Wei, M., & Chen, J.* Role of N6-methyladenosine modification in cancer. Curr Opin Genet Dev. 2017, 48:1-7.
  • Weng, H., Huang, H., Wu, H., Qin, X., Zhao, B.S., Dong, L., Shi, H., Skibbe, J., Shen, C., Hu, C., Sheng, Y., Wang, Y., Wunderlich, M., Zhang, B., Dore, L.C., Su, R., Deng, X., Ferchen, K., Li, C., Sun, M., Lu, Z., Jiang, X., Marcucci, G., Mulloy, J.C., Yang, J., Qian, Z., Wei, M.*, He, C.*, & Chen, J.* METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification. Cell Stem Cell. 2017, S1934-5909(17)30468-X.
  • Su, R., Dong, L., Li, C., Nachtergaele, S., Wunderlich, M., Qing, Y., Deng, X., Wang, Y., Weng, X., Hu, C., Yu, M., Skibbe, J., Dai, Q., Zou, D., Wu, T., Yu, K., Weng, H., Huang, H., Ferchen, K., Qin, X., Zhang, B., Qi, J., Sasaki, A.T., Plas, D.R., Bradner, J.E., Wei, M., Marcucci, G., Jiang, X., Mulloy, J.C., Jin, J.*, He, C.*, & Chen, J.* Cell. 2017, S0092-8674(17)31382-X.
  • Deng, X. & Nakamura, Y.* Cancer precision medicine: from cancer screening to drug selection and personalized immunotherapy. Trends Pharmacol Sci. 2017, 38:15-24.
  • Deng, X., Hamamoto, R., Vougiouklakis, T., Wang, R., Yoshioka, Y., Suzuki, T., Dohmae, N., Matsuo, Y., Park, J.H., & Nakamura, Y.* Critical roles of SMYD2-mediated β-catenin methylation for nuclear translocation and activation of Wnt signaling. Oncotarget. 2017, 8:55837-55847.
  • Wang, R., Deng, X., Yoshioka, Y., Vougiouklakis, T., Park, J.H., Suzuki, T., Dohmae, N., Ueda, K., Hamamoto, R., & Nakamura, Y.* Effects of SMYD2-mediated EML4-ALK methylation on the signaling pathway and growth in non-small-cell lung cancer cells. Cancer Sci. 2017, 108:1203-1209.
  • Saloura, V., Vougiouklakis, T., Zewde, M., Deng, X., Kiyotani, K., Park, J.H., Matsuo, Y., Lingen, M., Suzuki, T., Dohmae, N., Hamamoto, R., & Nakamura, Y.* WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR in head and neck cancer. Sci Rep. 2017,7:40664.
  • Deng, X., Von, Keudell, G., Nakakido, M., Piao, L., Yoshioka, Y., Suzuki, T., Dohmae, N., Nakamura Y, & Hamamoto R.* PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP. Oncotarget. 2015, 6(34):35173-82.
  • Deng, X., Yuan, Y.Z., Adams, E., & Van Schepdael, A.Development and validation of a sensitive enantiomeric separation method for new single enantiomer drug levornidazole by CD-capillary electrophoresis.Talanta. 2013, 106:186-191.
  • Yuan, Y., Chopra, S., Deng, X., Zhang, M., Fan, X., Hu, C., Jin, S., Van Schepdael, A., & Adams, E. Analysis of micronomicin by liquid chromatography with pulsed electrochemical detection. J Chromatogr A. 2013, 1295:90-8.
  • De Winter, S., Vanbrabant, P., Tuong Vi, N.T., Deng, X., Spriet, I., Van Schepdael, Ann., Gillet, J.B.* The influence of thermal exposure on the stability of prehospital drugs labeled for refrigeration. Eur J Emerg Med. 2013, 62:380-387.
  • Yeniceli, D., Deng, X., Adams, E., & Van Schepdael, A.* Development of a CD-MEKC method for investigating the metabolism of tamoxifen by flavin-containing monooxygenases and the inhibitory effects of methimazole, nicotine and DMXAA. Electrophoresis. 2013, 34:463-70.
  • Deng, X., De Cock, B., Vervoort, R., Pamperin, D., Adams, E., Van Schepdael, A.* Development of a validated capillary electrophoresis method for enantiomeric purity control and quality control of levocetirizine in a pharmaceutical formulation. Chirality. 2012, 24:276-82.
  • Deng, X., De Wolf, J., Vervoort, R., Pamperin, D., Adams, E., Van Schepdael, A.* Development and validation of a capillary electrophoresis method for the determination of escitalopram and sensitive quantification of its enantiomeric impurity in formulations. Electrophoresis. 2012, 33:1-4.
  • Deng, X., Hai, X., Vervoort, R., Pamperin, D., Adams, E., & Van Schepdael, A.* Development and validation of a chiral capillary electrophoresis method for assay and enantiomeric purity control of pramipexole. J Sep Sci. 2011, 34:3070-6.