Xiaolan Deng
Assistant Research Professor, Department of Systems Biology
Research Area
New cancer therapy targeting methyltransferse
Role of m6A modification in acute myeloid leukemia
Research Teams
2013, Ph.D., Pharmaceutical Sciences, University of KU Leuven, Belgium
2010, M.S., Pharmaceutical Sciences, University of KU Leuven, Belgium
2008, B.S., Pharmaceutical Sciences, Shenyang Pharmaceutical University, China
2020-present, Assistant Research Professor, Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA
2018-2020, Staff Scientist, Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA
2017-2018, Postdoctoral Fellow, Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA
2016-2017, Postdoctoral Fellow, Department of Cancer Biology, University of Cincinnati, Cincinnati, OH
2014-2016, Postdoctoral Fellow, Department of Medicine, University of Chicago, Chicago, IL
2013, Travel Award Recipient Faculty of Pharmacy, KU Leuven, Belgium
2012, Poster Presentation Award, 1st Spring Symposium, KU Leuven, Belgium
2009, Distinguished Dissertation Award, KU Leuven, Belgium
2008, Award of Excellence for dissertation, Shenyang Pharmaceutical University, China
2008, Award in Excellence, College of Pharmacy, Shenyang
Pharmaceutical University, China
2014-2015 International Conference on Imaging Systems and Techniques
2014-2015, Steering Committee Member on IEEE
- Su R, Dong L, Li Y, Gao M, Han L, Wunderlich M, Deng X, Li H, Huang Y, Gao L, Li C, Zhao Z, Robison S, Tan B, Qing Y, Qin X, Prince E, Xie J, Qin H, Li W, Shen C, Sun J, Prakash K, Weng H, Huang H, Chen Z, Zhang B, Wu X, Olsen MJ, Muschen M, Marcucci G, Ravi S, Li, L, Fathi AT, Li Z, Mulloy JC, Wei M, Horne D, Chen J*. Targeting FTO suppresses cancer stem cell maintenance and immune evasion. Cancer Cell. 2020 Jul 13;38(1):79-96. PMCID: PMC7363590.
- Shen C, Sheng Y, Zhu A, Robinson S, Jiang X, Dong L, Chen H, Su R, Yin Z, Li W, Deng X, Chen Y, Hu YC, Weng H, Huang H, Prince E, Cogle CR, Sun M, Zhang B, Chen CW, Marcucci G, He C*, Qian Z*, Chen J*. RNA demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia. Cell Stem Cell. 2020 Jul 2;27(1):64-80. PMCID: PMC7335338.
- Huang H, Weng H, Deng X, Chen J*. RNA Modifications in Cancer: Functions, Mechanisms and Therapeutic Implications. Annual Review of Cancer Biology. 2020; 4:221-240.
- Li C, Dong L, Su R, Bi Y, Qing Y, Deng X, Zhou Y, Hu C, Yu M, Huang H, Jiang X, Li X, He X, Zou D, Shen C, Han L, Sun M, Skibbe J, Ferchen K, Qin X, Weng H, Huang H, Song C, Chen J*, Jin J*. Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC. Haematologica. 2019, DOI: 10.3324/haematol.2018.208835.
- Huang H, Weng H, Zhou K, Wu T, Zhao BS, Sun M, Chen Z, Deng X, Xiao G, Auer F, Klemm L, Wu H, Zuo Z, Qin X, Dong Y, Zhou Y, Qin H, Tao S, Du J, Liu J, Lu Z, Yin H, Mesquita A, Yuan CL, Hu YC, Sun W, Su R, Dong L, Shen C, Li C, Qing Y, Jiang X, Wu X, Sun M, Guan JL, Qu L, Wei M, Müschen M, Huang G, He C, Yang J, Chen J. Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally. Nature. 2019, 567:414-419.
- Deng X, Su R, Stanford S, Chen J*. Critical enzymatic Functions of FTO in Obesity and Cancer. Front Endocrinol. 2018, 9:396-403.
- Deng X*, Su R, Huang H, Weng H, Li Z, Chen J*. N6-methyladenosine in Cancers: Function, Mechanism and Therapeutic Implication. Cell Research. 2018, 28(5): 507-517.
- Deng X*, Su R, Feng X, Wei M, Chen J*. Role of N6-methyladenosine modification in cancer. Curr Opin Genet Dev. 2017, 48:1-7.
- Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich M, Zhang B, Dore LC, Su R, Deng X, Ferchen K, Li C, Sun M, Lu Z, Jiang X, Marcucci G, Mulloy JC, Yang J, Qian Z, Wei M*, He C*, Chen J*. METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification. Cell Stem Cell. 2017, S1934-5909(17)30468-X.
- Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, Skibbe J, Dai Q, Zou D, Wu T, Yu K, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki AT, Plas DR, Bradner JE, Wei M, Marcucci G, Jiang X, Mulloy JC, Jin J*, He C*, Chen J*. Cell. 2017, S0092-8674(17)31382-X.
- Deng X, Nakamura Y*. Cancer precision medicine: from cancer screening to drug selection and personalized immunotherapy. Trends Pharmacol Sci. 2017, 38:15-24.
- Deng X, Hamamoto R, Vougiouklakis T, Wang R, Yoshioka Y, Suzuki T, Dohmae N, Matsuo Y, Park JH, Nakamura Y*. Critical roles of SMYD2-mediated β-catenin methylation for nuclear translocation and activation of Wnt signaling. Oncotarget. 2017, 8:55837-55847.
- Wang R, Deng X, Yoshioka Y, Vougiouklakis T, Park JH, Suzuki T, Dohmae N, Ueda K, Hamamoto R, Nakamura Y*. Effects of SMYD2-mediated EML4-ALK methylation on the signaling pathway and growth in non-small-cell lung cancer cells. Cancer Sci. 2017, 108:1203-1209.
- Saloura V, Vougiouklakis T, Zewde M, Deng X, Kiyotani K, Park JH, Matsuo Y, Lingen M, Suzuki T, Dohmae N, Hamamoto R, Nakamura Y*. WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR in head and neck cancer. Sci Rep. 2017,7:40664.
- Deng X, Von Keudell G, Nakakido M, Piao L, Yoshioka Y, Suzuki T, Dohmae N, Nakamura Y, Hamamoto R*. PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP. Oncotarget. 2015, 6(34):35173-82.
- Deng X, Yuan YZ, Adams E, Van Schepdael A*. Development and validation of a sensitive enantiomeric separation method for new single enantiomer drug levornidazole by CD-capillary electrophoresis. Talanta. 2013, 106:186-191.
- Yuan Y, Chopra S, Deng X, Zhang M, Fan X, Hu C, Jin S, Van Schepdael A, Adams E*. Analysis of micronomicin by liquid chromatography with pulsed electrochemical detection. J Chromatogr A. 2013, 1295:90-8.
- De Winter S, Vanbrabant P, N.T. Tuong Vi, Deng X, Spriet I, Van Schepdael Ann, Gillet J.B*. The influence of thermal exposure on the stability of prehospital drugs labeled for refrigeration. Eur J Emerg Med. 2013, 62:380-387.
- Yeniceli D, Deng X, Adams E, Van Schepdael A*. Development of a CD-MEKC method for investigating the metabolism of tamoxifen by flavin-containing monooxygenases and the inhibitory effects of methimazole, nicotine and DMXAA. Electrophoresis. 2013, 34:463-70.
- Deng X, De Cock B, Vervoort R, Pamperin D, Adams E, Van Schepdael A*. Development of a validated capillary electrophoresis method for enantiomeric purity control and quality control of levocetirizine in a pharmaceutical formulation. Chirality. 2012, 24:276-82.
- Deng X, De Wolf J, Vervoort R, Pamperin D, Adams E, Van Schepdael A*. Development and validation of a capillary electrophoresis method for the determination of escitalopram and sensitive quantification of its enantiomeric impurity in formulations. Electrophoresis. 2012, 33:1-4.
- Deng X, Hai X, Vervoort R, Pamperin D, Adams E, Van Schepdael A*. Development and validation of a chiral capillary electrophoresis method for assay and enantiomeric purity control of pramipexole. J Sep Sci. 2011, 34:3070-6.