Xiaolan Deng, Ph.D.

Scholarship

• Chen M, Shen C, Chen Y, Chen Z, Zhou K, Chen Y, Li W, Zeng C, Qing Y, Wu D, Xu C, Tang T, Che Y, Qin X, Xu Z, Wang K, Leung K, Sau L, Deng X*, Hu J*, Wu Y*, Chen J*. Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling. Cell Rep Med. 2024, 5(7):101645.
• Chen M, Chen Y, Wang K, Deng X*, Chen J*. Non?m6A RNA modifications in hematological malignancies. Clin Transl Med. 2024,14(6):e1666.
• Zhang Z, Zhou K, Han L, Small A, Xue J, Huang H, Weng H, Su R, Tan B, Shen C, Li W, Zhao Z, Qing Y, Qin X, Wang K, Leung K, Boldin M, Chen CW, Ann D, Qian Z, Deng X*, Chen J*, Chen Z*. RNA m6A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression. Genes Dis, 2023 Mar 28;11(1):382-396.
• Li Y#, Xue M#, Deng X#, Dong L#, Nguyen LXT, Ren L, Han L, Li C, Xue J, Zhao Z, Li W, Qing Y, Shen C, Tan B, Chen Z, Leung K, Wang K, Swaminathan S, Li L, Chen Y, Wunderlich M, Mulloy JC, Li X, Chen H, Zhang B, Horne D, Rosen ST, Marcucci G, Xu M, Li Z, Wei M, Tian J, Shen B, Su R, Chen J. TET2-mediated mRNA oxidation facilitates leukemia stem cell homing and self-renewal. Cell Stem Cell. 2023, 3;30(8):1072-1090.e10.
• Deng X, Qing Y, Chen J. Targeting YTHDF2/MDSCs to improve radiotherapy. Cell Chem Biol 
  2023, 20;30(7):703-705.
• Deng X*, Qing Y, Horne D, Huang H*, Chen J*. The roles and implications of RNA m6A modification in cancer. Nature Reviews Clinical Oncology. 2023, 20(8):507-526.
• Chen Z, Zhou K, Xue J, Small A, Xiao G, Nguyen L, Zhang Z, Prince E, Weng H, Huang H, Zhao Z, Qing Y, Shen C, Li W, Han L, Tan B, Su R, Qin H, Li Y, Wu D, Gu Z, Ngo V, He X, Chao J, Leung K, Wang K, Dong L, Qin X, Cai Z, Sheng Y, Chen Y, Wu X, Zhang B, Shi Y, Marcucci G, Qian Z, Xu M, Müschen M, Chen J*, Deng X*. Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B-cell acute lymphoblastic leukemia. Science Translational Medicine. 2023, 15(689): eabq8513.
• Han L, Dong L, Leung K, Zhao Z, Li Y, Gao L, Chen Z, Xue J, Qing Y, Li W, Pokharel SP, Gao M, Chen M, Shen C, Tan B, Small A, Wang K, Zhang Z, Qin X, Yang L, Zhang B, Marcucci G, Chen CW, Wei M*, Su R*, Chen J*, Deng X*. METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism. Cell Stem Cell. 2023, 30(1):52-68.
• Shen C, Wang K, Deng X*, Chen J*. DNA N(6)-methyldeoxyadenosine in mammals and human diseases. Trends in Genetics. 2022 Jan 3;S0168-9525(21)00353-X.
• Deng X, Su R, Stanford S, Chen J. Critical enzymatic Functions of FTO in Obesity and Cancer. Frontiers in Endocrinology. 2018, 9:396-403.
• Deng X*, Su R, Huang H, Weng H, Li Z, Chen J*. RNA N6-methyladenosine modification in cancers: current status and perspectives Cell Research. 2018, 28(5): 507-517.
• Deng X*, Su R, Feng X, Wei M, Chen J*. Role of N6-methyladenosine modification in cancer. Current Opinion in Genetics & Development. 2017, 48:1-7. 

Co-Author Publications 

• Xue M, Dong L, Zhang H, Li Y, Qiu K, Zhao Z, Gao M, Han L, Chan AKN, Li W, Leung K, Wang K, Pokharel SP, Qing Y, Liu W, Wang X, Ren L, Bi H, Yang L, Shen C, Chen Z, Melstrom L, Li H, Timchenko N, Deng X, Huang W, Rosen ST, Tian J, Xu L, Diao J, Chen CW, Chen J, Shen B, Chen H, Su R. METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation. J Hematol Oncol, 2024,17(1):7.
• Zhao Z#, Qing Y#, Deng X, Su R, Chen J. The roles and therapeutic implications of messenger RNA internal N7 -methylguanosine and N6 -methyladenosine modifications in chemoresistance. Clin Transl Med, 2023,13(9):e1400. (IF:10.6)
• Tan B, Zhou K, Liu W, Prince E, Qing Y, Li Y, Han L, Qin X, Su R, Pokharel SP, Yang L, Zhao Z, Shen C, Li W, Chen Z, Zhang Z, Deng X, Small A, Wang K, Leung K, Chen CW, Shen B, Chen J. RNA N6 -methyladenosine reader YTHDC1 is essential for TGF-beta-mediated metastasis of triple negative breast cancer. Theranostics. 2022 Jul 18;12(13):5727-5743. (IF:12.29)
• Li W, Deng X, Chen J*. RNA-binding Proteins in Regulating mRNA Stability and Translation: Roles and Mechanisms in Cancer. Seminars in Cancer Biology. 2022 Nov;86(Pt 2):664-677. (IF:17.01)
• Li Y, Su R, Deng X, Chen Y, Chen J*. FTO in cancer: Functions, molecular mechanisms and therapeutic implications. Trends in Cancer. 2022 Jul;8(7):598-614. (IF:12.29)
• Su R*, Dong L, Gao M, Li Y, He PC, Liu W, Wei J, Gao L, Han L, Deng X, Zhao Z, Prince E, Tan B, Qing Y, Qin X, Shen C, Zhou K, Chen Z, Xue J, Li W, Qin H, Wu X, Sun M, Nam Y, Chen CW, Horne D, Rosen ST, He C*, Chen J*. METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis. Nature Cell Biology. 2022 Feb;24(2):205-216. (IF:28.21)  
• Qing Y, Dong L, Gao L, Li C, Li Y, Han L, Prince E, Tan B, Deng X, Wetzel C, Shen C, Gao M, Chen Z, Li W, Zhang B, Braas D, Hoeve Jt, Sanchez GJ, Chen H, Chan LN, Chen CW, Ann D, Jiang L, Müschen M, Marcucci G, Plas DP, Li Z, Su R*, Chen J*. R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis. Molecular Cell. 2021 Mar 4;81(5):922-939. (IF:19.33)  
• Huang H, Weng H, Deng X, Chen J*. RNA Modifications in Cancer: Functions, Mechanisms and Therapeutic Implications. Annual Review of Cancer Biology. 2020; 4:221-240. (IF:13.34)  
• Su R, Dong L, Li Y, Gao M, Han L, Wunderlich M, Deng X, Li H, Huang Y, Gao L, Li C, Zhao Z, Robison S, Tan B, Qing Y, Qin X, Prince E, Xie J, Qin H, Li W, Shen C, Sun J, Prakash K, Weng H, Huang H, Chen Z, Zhang B, Wu X, Olsen MJ, Muschen M, Marcucci G, Ravi S, Li, L, Fathi AT, Li Z, Mulloy JC, Wei M, Horne D, Chen J*. Targeting FTO suppresses cancer stem cell maintenance and immune evasion. Cancer Cell. 2020 Jul 13;38(1):79-96. (IF:48.23)
• Shen C, Sheng Y, Zhu A, Robinson S, Jiang X, Dong L, Chen H, Su R, Yin Z, Li W, Deng X, Chen Y, Hu YC, Weng H, Huang H, Prince E, Cogle CR, Sun M, Zhang B, Chen CW, Marcucci G, He C*, Qian Z*, Chen J*. RNA demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia. Cell Stem Cell. 2020 Jul 2;27(1):64-80.
• Li C, Dong L, Su R, Bi Y, Qing Y, Deng X, Zhou Y, Hu C, Yu M, Huang H, Jiang X, Li X, He X, Zou D, Shen C, Han L, Sun M, Skibbe J, Ferchen K, Qin X, Weng H, Huang H, Song C, Chen J*, Jin J*. Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC. Haematologica. 2020 Jan;105(1):148-160. (IF:13.81)
• Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich M, Zhang B, Dore LC, Su R, Deng X, Ferchen K, Li C, Sun M, Lu Z, Jiang X, Marcucci G, Mulloy JC, Yang J, Qian Z, Wei M*, He C*, Chen J*. METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification. Cell Stem Cell. 2017, S1934-5909(17)30468-X. (IF:25.27)   
• Zhao Z, Qing Y, Dong L, Han L, Wu D, Li Y, Li W, Xue J, Zhou K, Sun M, Tan B, Chen Z, Shen C, Gao L, Small A, Wang K, Leung K, Zhang Z, Qin X, Deng X, Xia Q,* Rui Su,* Chen J*. QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism. Cell, 2023 Jul 20;186(15):3208-3226.e27.
• Weng H, Huang F, Yu Z, Chen Z, Prince E, Kang Y, Zhou K, Li W, Hu J, Fu C, Aziz T, Li H, Li J, Yang Y, Han L, Zhang S, Ma Y, Sun M, Wu H, Zhang Z, Wunderlich M, Robinson S, Braas D, Hoeve JT, Zhang B, Marcucci G, Mulloy JC, Zhou K, Tao HF, Deng X, Horne D, Wei M, Huang H, Chen J. The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer Cell. 2022 Dec 12;40(12):1566-1582.
• Huang H, Weng H, Zhou K, Wu T, Zhao BS, Sun M, Chen Z, Deng X, Xiao G, Auer F, Klemm L, Wu H, Zuo Z, Qin X, Dong Y, Zhou Y, Qin H, Tao S, Du J, Liu J, Lu Z, Yin H, Mesquita A, Yuan CL, Hu YC, Sun W, Su R, Dong L, Shen C, Li C, Qing Y, Jiang X, Wu X, Sun M, Guan JL, Qu L, Wei M, Müschen M, Huang G*, He C*, Yang J*, Chen J*. Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally. Nature. 2019, 567:414-419.
• Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, Hüttelmaier S, Skibbe J, Su R, Deng X, Dong L, Sun M, Li C, Nachtergaele S, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X, Wei M, Qu L, Guan JL, He C*, Yang J*, Chen J*. Recognition of RNA N6-methyadenosine by IGF2BP proteins Enhances mRNA Stability and Translation. Nature Cell Biology. 2018, 20(3):285-295.
• Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, Skibbe J, Dai Q, Zou D, Wu T, Yu K, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki AT, Plas DR, Bradner JE, Wei M, Marcucci G, Jiang X, Mulloy JC, Jin J*, He C*, Chen J*. R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling. Cell. 2017, S0092-8674(17)31382-X.