Andrew Nguyen, M.D.

Andrew Nguyen, M.D., is an assistant clinical professor in the Division of Surgical Oncology in the Department of Surgery at City of Hope. He received his Bachelor of Science from the University of California San Diego, where he graduated Phi Beta Kappa, magna cum laude. After attending medical school at New York University School of Medicine, he received his surgical training at the David Geffen School of Medicine at UCLA, followed by a complex surgical oncology fellowship at City of Hope. Dr. Nguyen was awarded a UCLA-CURE NIH T32 Training Grant and the Gerald S. Levey Surgical Research Award. His research work has centered on dendritic cell biology and targeting MicroRNA-regulated networks in pancreatic cancer. Dr. Nguyen sees general surgical oncology patients, including melanoma, sarcoma and gastrointestinal cancers at City of Hope’s South Bay location.

2013-2016, Study of Histone Deacetylase Inhibitors in Pancreatic Cancer Microenvironment, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA. Mentor: Timothy Donahue, M.D.

2013-2015, Revising Surgical Indications for Intraductal Papillary Mucinous Neoplasms, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA. Mentor: Timothy Donahue, M.D.

2013-2017, Targeting MicroRNA-Regulated Networks in Human Pancreatic Cancer, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA. Mentor: Timothy Donahue, M.D.

2010-2011, Divergent population of lipid-laden hepatic dendritic cells, Department of Surgery, New York University School of Medicine, New York, NY. Mentor: George Miller, M.D.

2010-2011, Dendritic cells protect against acute acetaminophen toxicity, Department of Surgery, New York University School of Medicine, New York, NY. Mentor: George Miller, M.D.

2010-2011, Dendritic cells in intrahepatic inflammation and fibrosis in non-alcoholic steatohepatitis, Department of Surgery, New York University School of Medicine, New York, NY. Mentor: George Miller, M.D.

2009-2011, Dendritic cells in pancreatitis and pancreatic carcinogenesis, Department of Surgery, New York University School of Medicine, New York, NY. Mentor: George Miller, M.D.

2009-2011, Prospective Clinical Pancreatitis Database, New York University School of Medicine, New York, NY. Mentors: Steven Cohen, D.O., Department of Surgery

2008-2009, Cardiac Magnetic Resonance Imaging Analysis, Tisch Hospital, New York, NY. Mentor: Barbara Srichai, M.D., Department of Radiology

• Evaluated cardiac anatomy and function, using a Siemens Syngo workstation

• Developed a clinical research database of cardiac MRI Manhattan VA patients
• 2011, published in American Journal of Cardiology

• Donnino R, Nguyen AH, Sedlis SP, Srichai M. Myocardial scar in diabetics and non-diabetics with ischemic heart disease as assessed by magnetic resonance imaging. Journal of Cardiovascular Magnetic Resonance, 2009.
• Donnino R, Michelin K, Aizer A, Nguyen AH, Babb J, Srichai M. Predictive value of electrocardiographic criteria for regional wall thickness in patients with cardiomyopathy. Journal of Cardiovascular Magnetic Resonance, 2010.
• Connolly MK, Ayo D, Malhotra A, Hackman M, Bedrosian AS, Ibrahim J, Malhotra A, Ciez-Rubio N, Nguyen AH, Pachter HL, Miller G. Dendritic cell depletion exacerbates acetaminophen hepatotoxicity. Hepatology. 2011. PMID: 21574173.
• Donnino R, Patel S, Nguyen AH, Sedlis SP, Babb JS, Schwartzbard A, Katz SD, Srichai MB. Comparison of Quantity of Left Ventricular Scarring and Remodeling by Magnetic Resonance Imaging in Patients With Versus Without Diabetes Mellitus and With Coronary Artery Disease. Am J Cardiol. 2011. PMID: 21439536
• Bedrosian AS*, Nguyen AH*, Hackman M, Connolly MK, Malhotra A, Ibrahim J, et al. Dendritic cells promote pancreatic viability in mice with acute pancreatitis. Gastroenterology. 2011;141(5):1915-26 e1-14. PMCID: 3202684.
• Marr M, Hemmert K, Nguyen AH, Combs R, Annamalai A, Miller G, et al. Team play in surgical education: a simulation-based study. J Surg Educ. 2012;69(1):63-9. PMCID: 22208835
• Nguyen AH, Bedrosian AS, Connolly M, Henning J, Medina-Zea V, Cieza-Rubio NE, Dorvil-Castro M, Graffeo C, Hackman M, Rehman A, Ibrahim J, Miller G. The Role of Dendritic Cell and Pancreatic Stellate Cell Cross-Talk in Chronic Pancreatitis. J Surg Research. 2012;172(2):223.
• Ibrahim J*, Nguyen AH*, Rehman A, Ochi A, Jamal M, Graffeo CS, et al. Dendritic Cell Populations with Different Concentrations of Lipid Regulate Tolerance and Immunity in Mouse and Human Liver. Gastroenterology. 10/2012. PMCID: 22705178
• Ochi A*, Nguyen AH*, Bedrosian AS, Mushlin HM, Zarbakhsh S, Barilla R, Zambirinis CP, Fallon NC, Rehman A, Pylayeva-Gupta Y, Badar S, Hajdu C, Frey AB, Bar-Sagi D, Miller G. MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med. 8/2012 Aug 27;209(9):1671-87. PMID: 22908323
• Nguyen AH, Donahue TR. Metastatic pancreatic insulinoma with treatment-limiting thrombocytopenia. Am Surg. 2013 Mar;79(3):124-6. PMID: 23461938
• Abouzeid M, Graffeo CS, Nguyen AH, Marr M, Ayo D, Obeid N, Bryk D, Pachter HL, Cohen S. Disparities Between Public and Private Hospitals Within a Single Academic Center in the Management of Gallstone Pancreatitis. Pancreatology, March 2013.
• Donahue TR*, Nguyen AH*, Li L, Moughan J, Li L, Tatishchev S, Toste P, Farrell JJ. Stromal MicroRNA-21 Levels Predict Response to 5-Fluorouracil in Patients with Pancreatic Cancer. J Surg Oncol. 2014 Dec;110(8):952-9. PMID: 25132574. PMCID: PMC4232442.
• Nguyen AH, Toste P, Farrell JJ, Clerkin BM, Muthusamy VR, Watson RR, Tomlinson JS, Hines OJ, Reber HA, Donahue TR. Current recommendations for surveillance and surgery of intraductal papillary mucinous neoplasms may overlook some patients with cancer. J Gastrointest Surg. 2015 Feb;19(2):258-65. PMID: 25373706. PMCID PMC4305480.
• Kadera BE, Toste PA, Wu N, Li L, Nguyen AH, Dawson DW, Donahue TR. Low Expression of the E3 Ubiquitin Ligase CBL Confers Chemoresistance in Human Pancreatic Cancer and Is Targeted by Epidermal Growth Factor Receptor Inhibition. Clin Cancer Res. 2015 Jan 1;21(1):157-65. PMID: 25348515. PMCID: PMC4286535.
• Toste PA, Li L, Kadera BE, Nguyen AH, Tran LM, Wu N, Madnick DL, Patel SG, Dawson DW, Donahue TR. p85α is a microRNA target and affects chemosensitivity in pancreatic cancer. J Surg Res. 2015 Jun
• 15;196(2):285-293. PMID: 25846727.
• Williams JL, Nguyen AH, Rochefort M, Muthusamy VR, Wainberg ZA, Dawson DW, Tomlinson JS, Hines OJ, Reber HA, Donahue TR. Pancreatic cancer patients with lymph node involvement by direct tumor extension have similar survival to those with node-negative disease. J Surg Oncol. 2015 Aug;112(4):396-402. doi: 10.1002/jso.24011. Epub 2015 Aug 25. PMID: 26303811
• Toste PA, Nguyen AH, Kadera BE, Duong M, Wu N, Gawlas I, Tran LM, Bikhchandani M, Li L, Patel SG, Dawson DW, Donahue TR. Chemotherapy-induced Inflammatory Gene Signature and Pro-tumorigenic Phenotype in Pancreatic CAFs via Stress-associated MAPK. Mol Cancer Res. 2016 Mar 15. pii: molcanres.0348.2015. PMID: 26979711
• Williams JL, Kadera BE, Nguyen AH, Muthusamy VR, Hines OJ, Reber HA, Donahue TR. CA19-9 Normalization During Pre-Operative Treatment Predicts Longer Survival for Patients with Locally Progressed Pancreatic Cancer. J Gastrointest Surg. 2016 Jul;20(7):1331-42. PMID: 27114246.
• Nguyen AV, Nyberg KD, Scott MB, Welsh AM, Nguyen AH, Wu N, Hohlbauch SV, Geisse NA, Gibb EA, Robertson AG, Donahue TR, Rowat AC. Stiffness of pancreatic cancer cells is associated with increased invasive potential. Integr Biol (Camb). 2016 Oct 20. PMID: 27761545.
• Nguyen AH, Elliot IA, Wu N, Matsumura C, Vogelauer M, Attar N, Dann A, Ghukasyan R, Toste PA, Patel SG, Williams JL, Li L, Dawson DW, Radu C, Kurdistani SK, Donahue TR. Histone Deacetylase Inhibitors Provoke a Tumor Supportive Phenotype in Pancreatic Cancer Associated Fibroblasts. Oncotarget. 2016 Nov 24. doi: 10.18632/oncotarget.13572. PMID: 27894105.
• Sugimoto M, Elliott IA, Nguyen AH, Kim S, Muthusamy VR, Watson R, Hines OJ, Dawson DW, Reber HA, Donahue TR. Assessment of a Revised Management Strategy for Patients With Intraductal Papillary Mucinous Neoplasms Involving the Main Pancreatic Duct. JAMA Surg. 2016 Nov 9. JAMA Surg. PMID: 27829085.
• Nguyen AH, Melstrom LG. Use of imaging as staging and surgical planning for pancreatic surgery. HepatoBiliary Surg Nutr 2019. doi: 10.21037/hbsn.2019.05.04
• De Andrade JP, Blakely AM, Nguyen AH, Ituarte PHG, Warner SG, Meltrom LG, Lee B, Singh G. Neuroendocrine Tumors of Meckel's Diverticula: Rare but Fare Well. American Surg. 2019 Oct. Accepted.
  *denotes co-first authorship