An NCI-designated Comprehensive Cancer Center

Colon and Rectal Cancer

Cancers of the colon and the rectum are the fourth-most commonly diagnosed cancers in the U.S. Because of their similarities, they are merged into a single category known as colorectal cancer. Although this disease is the third-leading cause of cancer death, thanks to more rigorous screening and regular treatment advances, the percentage of deaths from colorectal cancer continues to drop.

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Our approach to treating colon and rectal cancers starts with personalized care — not just for your cancer, but the kind that makes you feel supported throughout your treatment. City of Hope's world-class colorectal team combines a multidisciplinary team approach with the newest, leading-edge colorectal genetic screening to provide you with the most accurate diagnosis and treatment path.

Our Expertise

“New drugs and combinations of drugs are more effective, surgical treatments have been refined and improved, and most patients are candidates for minimally invasive surgical techniques that have less pain and faster recovery.”

Stephen Sentovich, M.D., M.B.A., Colorectal Surgeon and Physician Lead, Clinical Operations

City of Hope is internationally recognized for its research and breakthrough treatments, has been named a "High Performing Hospital" for colon cancer surgery and one of America’s top cancer hospitals by U.S. News & World Report for more than a decade and is a National Cancer Institute-designated comprehensive cancer center. City of Hope clinical network locations are throughout Southern California with its main campus northeast of Los Angeles.

Our commitment to providing the best care for you includes:

  • Surgeons expert in minimally invasive techniques, including robotic and laparoscopic surgeries, for smaller incisions, less pain and faster recovery.       
  • Surgeons who know how to do everything possible to avoid a colostomy.
  • Colorectal surgeons specializing in complicated, late-stage cancers using combined colon and liver operations performed with our world-renowned liver surgery team.
  • Ultraprecise radiation and chemotherapy to target tumors and preserve healthy tissue.
  • Hyperthermic intraperitoneal chemotherapy, a complex treatment that involves removing widespread cancer then delivering heated chemotherapy directly to the abdomen.
  • Expertise in hereditary cancer syndromes, including use of next-generation DNA sequencing methods.
  • Genetic targeting used to figure out a tumor’s specific biology and to design treatments to stop it from growing.
  • Supportive care that continues long after treatment ends, including helping you and your family adjust to post-treatment diet and lifestyle changes.

At City of Hope we see complicated colon and rectal cancer cases every day, so we are experts at treating advanced and recurrent disease. That treatment happens just steps away from groundbreaking research and clinical trials — happening right on City of Hope’s campus — that could directly impact how we treat your cancer.  

When we care for you at City of Hope, we are not just focused on leading-edge care and innovation — we are working to make you whole again.


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