An NCI-designated Comprehensive Cancer Center

Skin Cancer and Melanoma

“I am simply so excited by how my life has changed and by what I learned about myself since being diagnosed.”
John Garner, Survivor

Skin cancer remains the most prevalent of all cancers in the United States, more common than all other cancer diagnoses combined. And while melanoma makes up just a small portion of those cases (about 1 percent), it is also the most deadly.

Getting treated for skin cancer at City of Hope gives you access to exceptional, coordinated care and makes you the focus of a comprehensive care team, including dermatologists, surgeons, medical oncologists, dermatopathologists and radiation oncologists, who are internationally recognized for their expertise and for shaping guidelines that are advancing the treatment of melanoma and other skin cancers.

Request a consultation

If you have been diagnosed with skin cancer or melanoma or are looking for a second opinion consultation about your treatment, request an appointment online or contact us at 800-826-4673. Please visit Making Your First Appointment for more information.

Our Expertise

City of Hope is internationally recognized for its research and breakthrough treatments, has been named one of America’s top cancer hospitals by U.S. News & World Report for more than a decade and is a National Cancer Institute-designated comprehensive cancer center.

It is one of only a few dozen centers in the country that treat skin cancer and melanoma using a comprehensive approach — by a multidisciplinary team whose sole focus is treating this type of cancer. Your care includes regular interaction and input from a team that includes oncologists, surgeons, radiation oncologists, dermatologists and pathologists, along with nurses, social workers and specially trained support staff. This team brings together deep experience and diverse perspectives — shaped by seeing and treating skin cancer every day — to arrive at the ideal treatment for every patient.

Our commitment to providing exceptional care includes

  • Promising new therapies as part of our clinical trials program, including novel intralesional injection therapies. These include commercially approved agents such as TVEC, an oncolytic virus, that directly targets melanoma tumors and is being studied in combination with other therapies.
  • Collaboration with the Melanoma Research Foundation, National Clinical Trials Network, Cytokine Working Group, SWOG Cancer Research Network and Cancer Immunotherapy Trials Network, providing quick access to the newest therapies and clinical trials.
  • Deep experience with immunotherapy-based treatments —  including involvement in pivotal clinical trials for now widely used drugs ipilimumab, nivolumab and pembrolizumab.
  • Expertise with isolated limb infusion, a focused chemotherapy treatment not currently available at most cancer centers.
  • Internationally trained dermatopathologist who combines clinical experience with leading-edge technology to provide the most accurate diagnosis.
  • Tumor testing and customized drug therapy tailored to the molecular profile of specific skin cancers.
  • Expertise in advanced facial reconstructive and microvascular procedures for patients with complex skin cancers.
  • Survivorship clinics — including physical therapy for lymphedema-related side effects — that provide support and monitoring throughout the course of the disease.

News & Breakthroughs


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