Division Chief and Associate Professor at City of Hope’s Toni Stephenson Lymphoma Center, Leslie L. Popplewell, M.D., is the principal investigator for a number of clinical trials examining new lymphoma therapies including CAR T cells and phase 1 and first in human trials. She is also working on advanced transplant techniques for patients whose lymphoma has recurred.
Dr. Popplewell received her medical degree from the University of Louisville School of Medicine. She joined City of Hope in 1998 following a fellowship at the renowned Memorial Sloan Kettering Cancer Center in New York City.
1996, Recipient, Merit Award, American Society of Hematology
1995, Recipient - Louis J. Treton Award - Most Outstanding 3rd Year Resident
CD47 blockade by Hu5F9-G4 and rituximab in non-Hodgkin's lymphoma
R Advani, I Flinn, L Popplewell, A Forero… - … England Journal of …, 2018 - Mass Medical Soc Abstract Background The Hu5F9-G4 (hereafter, 5F9) antibody is a macrophage immune checkpoint inhibitor blocking CD47 that induces tumor-cell phagocytosis. 5F9 synergizes with rituximab to eliminate B-cell non-Hodgkin's lymphoma cells by enhancing macrophage …
AK Gopal, R Levy, R Houot, SP Patel, L Popplewell… - Clinical Cancer …, 2020 - AACR Purpose: In this phase I study (NCT01307267), we evaluated safety, pharmacokinetics, clinical activity, and pharmacodynamics of treatment with utomilumab plus rituximab in patients with relapsed/refractory follicular lymphoma (FL) and other CD20+ non-Hodgkin … Cited by 9Related articlesAll 6 versions
CD19-targeting CAR-T cell therapy in CNS lymphoma
T Siddiqi, X Wang, J Palmer, LL Popplewell… - 2019 - ashpublications.org Background: Prognosis is generally poor for patients (pts) with primary or secondary central nervous system (CNS) lymphoma. We report data from such patients treated on the ongoing
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We always refer City of Hope to our friends as having the best doctors and treatments. - Verified patient
Very good experience! - Verified patient
Professional, well trained, and experienced staff! Very kind as well. - Verified patient
I am patient of Dr. Popplewell almost five (5) years. She guiding myself from the beginning of my medical condition from serious level to "cancer free" situations! All credits going to Dr. Popplewell and City at Hope! THANKS - Verified patient
Wonderfully thorough and clear explanations and takes time to hear and discuss concerns. - Verified patient