Zhen Chen, Ph.D.

Research Focus :
  • Epigenetic regulation in endothelial stress response and its functional and translational relevance in cardiovascular diseases.
Zhen Chen, Ph.D., joined the Diabetes and Metabolism Research Institute as assistant professor in the department of Diabetes Complications and Metabolism. Dr. Chen comes to the City of Hope after four years as a postdoctoral fellow at University of California San Diego, where she was jointly trained in the departments of Medicine and Bioengineering.
 
Dr. Chen’s postdoctoral research on microRNA-mediated endothelial stress response was supported by an American Heart Association (AHA) Postdoctoral Fellowship and is currently funded by a K99/R00 Career Development Award from the National Heart, Lung and Blood Institute (NHLBI).

Dr. Chen received her medical training in Basic Medical Sciences from Peking University Health Science Center, where she received the prize for "Best Thesis Research.”

She then pursued her doctoral studies in mechanosensing and vascular biology at University of California Riverside, where she received the Joy K. Tilton Cancer Research Award and an Outstanding Achievement Award in Biomedical Sciences. She was a finalist for an American Heart Association Junior Investigator Award for Women. She has served as a reviewer for journals Circulation, Circulation Research, Arteriosclerosis, Thrombosis, and Vascular Biology, and AHA Scientific Sessions.

During her research training, Dr. Chen has had several high-profile publications as first author (Journal of Clinical Investigation, Circulation, Proceedings of the National Academy of Sciences, and Circulation Research) and coauthor, and more recently as a corresponding author, (Circulation).
 
Dr. Chen is interested in elucidating the molecular mechanisms by which non-coding RNA and other epigenetic modifications mediate endothelial response to hypoxia and oxidative stress, including angiogenesis, innate immune response, and inflammation, and furthermore characterizing their implications in cancer and diabetic vascular complications. She is particularly interested in integrating innovative high-throughput sequencing technologies, systems biology and bioinformatics approaches in tackling these biomedical challenges.

Dr. Chen's research group is focused on understanding molecular basis underlying cardiovascular complications of diabetes and identifying novel strategies in treatment of these complications.
 
  • 2016 - present, Assistant Professor, Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA
  • 2012 - 2016, Postdoctoral scholar, Division of Cardiology, University of California, San Diego, CA
  • 2010 - 2012 Postdoctoral scholar, Division of Biomedical Sciences, University of California, Riverside, CA
  • 2010, Visiting scholar, Genomics Research Center, Academia, Sinica, Taiwan
  • 2006 - 2010, PhD candidate, Division of Biomedical Sciences, University of California Riverside, CA
  • 2004 - 2005, Undergraduate research assistant, Department of Physiology and Diabetes Center, Peking University Health Science Center, China
  • Diabetes Complications & Metabolism

Degrees

  • 2010, Ph.D. in Biomedical Sciences, University of California, Riverside, CA
  • 2005, B.S. in Basic Medical Sciences, Peking University Health Science Center, China
  • Fengqing Shang, Zhao Li, Traci L. Marin, Brendan Gongol, Jin Zhang, Jiao Zhang, Han Xiao, Youyi Zhang, Zhen Chen, John Y-J Shyy, and Ting Lei. AMPK Phosphorylation of PARP1 Is Endothelium-Protective: Implications for Metformin and Telmisartan Treatment. PLoS One. 2016.
  • Zhen Chen*, Liang Wen, Marcy Martin, Chien-Yi Hsu, Longhou Fang, Feng-Mao Lin, Ting-Yang Lin, McKenna J. Geary, Gregory Geary, Yongli Zhao, David A. Johnson, Shu Chien,Hsien-Da Huang, Yury I. Miller, Po-Hsun Huang, and John Y-J. Shyy. Oxidative stress activates endothelial innate immunity through SREBP2 transactivation of miR-92a.Circulation. 2015. (*Co-corresponding author)
  • John P. Cooke and Zhen Chen. A Compendium on Peripheral Arterial Disease. Circ Res.2015.
  • Zhen Chen, Marcy Martin, Zhao Li, and John Y-J. Shyy. Endothelial Dysfunction: The Role of SREBP-Induced NLRP3 Inflammasome in Atherosclerosis. Curr Opin Lipid. 2014.
  • Xiaohong Wang, Xi Fang, Jing Zhou, Zhen Chen, Beibei Zhao, Liang Xiao, Ao Liu, Yi-Shuan Li, John Y-J. Shyy, Youfei Guan, Shu Chien, and Nanping Wang. Shear stress activation of PXR in endothelial detoxification. Proc Natl Acad Sci U S A. 2013
  • Liang Wen, Zhen Chen, Ji Jiang, Fan Zhang, Xiaopei Cui, Wei Sun, Greg G. Geary,Yinsheng Wang, David A. Johnson, Yi Zhu, and John Y-J. Shyy. Ca2+/calmodulin-dependent Protein Kinase Kinase β Phosphorylation of Sirtuin 1 in Endothelium Is Atheroprotective. Proc Natl Acad Sci U S A. 2013.
  • Han Xiao, Min Lu, Ting Yang Lin, Zhen Chen, Gang Chen, Wei-Chi Wang, Traci Marin, Tzu-pin Shentu, Liang Wen, Brendan Gongol, Wei Sun, Xiao Liang, Ju Chen, Hsien-Da Huang, Joao Pedra, David A. Johnson, and John Y-J. Shyy SREBP2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility. Circulation. 2013.
  • Zhen Chen, Tsung-Ching Lai, Yi-Hua Jan, Feng-Mao Lin, Wei-Chi Wang, Han Xiao, Yun-Ting Wang, Wei Sun, Xiaopei Cui, Ying-Shiuan Li, Tzan Fang, Hongwei Zhao, Chellappan Padmanabhan, Ruobai Sun, Danny Ling Wang, Hailing Jin, Gar-Yang Chau, Hsien-Da Huang, Michael Hsiao, and John Y-J. Shyy. Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. J Clin Invest. 2013.
  • Traci Marin, Brendan Gongol, Zhen Chen, Brian Woo, Shankar Subramaniam, Shu Chien, John Y-J. Shyy. Mechanosensitive microRNAs-Role in Endothelial Responses to Shear Stress and Redox State. Free Radic. Biol. Med. 2013.
  • Zhen Chen, Tzu-Pin Shentu, Liang Wen, David A. Johnson, and John Y-J. Shyy. Regulation of SIRT1 by Oxidative Stress-Responsive miRNAs in the Endothelium. Antioxid Redox Signal. 2013.
  • I-Chen Peng, Zhen Chen, Wei Sun, Ying-Shiuan Li, Traci Lanai Marin, Pang-Hung Hsu, Mei-I Su, Xiaopei Cui, Songqin Pan, Christian Lytle, David A. Johnson, Frank Blaeser, Talal Chatila, John Y-J. Shyy. Glucagon regulates ACC activity in adipocytes through the CaMKKβ/AMPK pathway. Am J Physiol Endocrinol Metab. 2012.
  • Hsin-Yi Chen, Yu-Min Lin, Hsiang-Ching Chung, Yaw-Dong Lang, Ching-Jung Lin, John Huang, Wei-Chi Wang, Feng-Mao Lin, Zhen Chen, Hsien-Da Huang, John Y.-J. Shyy, Jin-Tung Liang, and Ruey-Hwa Chen. miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4. Cancer Res. 2012.
  • John Y-J. Shyy, Zhen Chen, Wei Wu and Wei Sun. Shear-Stress Activation of AMPActivated Protein Kinase in Endothelial Homeostasis. Cell Mol Bioeng. 2011.
  • Zhen Chen, I-Chen Peng, Xiaopei Cui, Yi-Shuan Li, Shu Chien, and John Y-J. Shyy. Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci U S A. 2010.
  • Zhen Chen, I-Chen Peng, Wei Sun, Mei-I Su, Pang-Hung Hsu, Yi Fu, Yi Zhu, Kathryn DeFea, Songqin Pan, Ming-Daw Tsai, and John Y-J. Shyy. AMP-Activated Protein Kinase Functionally Phosphorylates Endothelial Nitric Oxide Synthase Ser633. Circ. Res. 2009.
  • 2014 Best of American Heart Association Specialty Conference: Arteriosclerosis, Thrombosis, and Vascular Biology
  • 2014 Junior Investigator Award for Women finalist, American Heart Association Arteriosclerosis, Thrombosis, and Vascular Biology Council Apr. 2014 K99 Career Development Award (K99HL122368), National Institute of Health, USA
  • 2011 Postdoctoral Fellowship (11POST7590128), American Heart Association Western States Affiliate Research Programs
  • 2005 Best Thesis, Institute of Basic Medical Sciences, Peking University Health Science Center May. 2010 Outstanding Achievement Award in Biomedical Sciences, University of California, Riverside Jun. 2007 Joy K. Tilton Cancer Research Award, University of California, Riverside
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