Bihong Beth Chen, M.D., Ph.D.

(877) 460-4673
Bihong (Beth) Chen
Neuroradiologist
Clinical Expertise
Neuroimaging
Functional Brain Magnetic Resonance Imaging
Research Area
Neuroimaging
Cancer-Related Cognitive Impairment
Appointments
Clinical Professor, Department of Diagnostic Radiology
Clinical Teams
Brain Tumors
Diagnostic Radiology
Head and Neck Cancers

Bihong Beth Chen, M.D., Ph.D., is a board-certified radiologist with fellowship training in neuroradiology (certificate of added qualification, CAQ) and interventional radiology.

Dr. Chen received her medical degree from Hunan Medical University in China and completed a diagnostic radiology residency at the University of Southern California. She continued her subspecialty training in neuroradiology and interventional radiology at the University of Southern California and the University of Washington.

A member of the radiology team at City of Hope® since 2007, Dr. Chen has extensive experience in brain magnetic resonance imaging techniques and is part of the team investigating cancer-related cognitive impairment.

Location

Education & Experience

Board Certifications

  • 2006, Certificate of Added Qualification in Neuroradiology, American Board of Radiology

  • 2001, Board Certification, American Board of Radiology

Degrees

  • 1990-1996, Ph.D., Pharmacology, Loma Linda University, Loma Linda, CA

  • 1981-1987, M.D., Hunan Medical University, Changsha, Hunan, P.R. China

Fellowship

  • 2005-2006, Combined Interventional Radiology and General Diagnostic Radiology Fellowship, University of Washington

  • 2001-2002, Neuroradiology Fellowship, University of Southern California, Los Angeles, CA

Residency

  • 1997-2001, Diagnostic Radiology Residency at University of Southern California, Los Angeles, CA

Professional Experience

  • 2021-present, Clinical Professor, Department of Diagnostic Radiology, City of Hope, Duarte, CA

  • 2007-present, Associate Clinical Professor and Staff Radiologist, Department of Radiology, City of Hope, Duarte, CA

  • 2006-2007, Assistant Professor, Division of Neuroradiology, Department of Radiology, University of Washington School of Medicine, Seattle, WA

  • 2002-2005, Staff Radiologist and Partner of Glendora Radiological Associates Inc., Covina, CA

  • 1987-1990, Assistant Professor, Department of Pharmacology, Hunan Medical University, P.R. China

Research

Dr. Chen’s research has focused on cancer-related cognitive impairment using advanced neuroimaging, radiomics and radiogenomics, and predictive modeling with machine learning for cancer imaging. Dr. Chen has conducted National Institutes of Health-supported clinical trials as a principal investigator assessing the effect of chemotherapy on brain structure and function in cancer patients and survivors. Dr. Chen’s research has also used imaging-based radiomic analysis and artificial intelligence algorithms to predict the mutation status of brain metastases. She is a principal investigator for multiple Institutional Review Board protocols and has over 100 publications in peer-reviewed journals with more than 1500 citations (h-index 23 & i10-index 36).

Awards & Memberships

Memberships

  • International Society for Magnetic Resonance in Medicine

  • Radiological Society of North America

  • American Society of Spine Radiology

  • American Society of Functional Neuroradiology

  • American Society of Neuroradiology

  • Society of Neuro-Oncology

  • Los Angeles Radiological Society

Publications

  • Daniel E, Deng F, Patel SK, Sedrak MS, Kim H, Razavi M, Sun CL, Root JC, Ahles TA, Dale W, Chen BT. Altered gyrification in chemotherapy-treated older long-term breast cancer survivors. Brain Behav. 2024 Aug;14(8):e3634. doi: 10.1002/brb3.3634. PMID: 37090667; PMCID: PMC10120747.
  • Daniel E, Deng F, Patel SK, Sedrak MS, Kim H, Razavi M, Sun CL, Root JC, Ahles TA, Dale W, Chen BT. Cortical thinning in chemotherapy-treated older long-term breast cancer survivors. Brain Imaging Behav, 2023; 17(1):66-76. PubMed PMID: 36369620; PubMed Central PMCID: PMC10156471.
  • de Ruiter MB, Deardorff RL, Blommaert J, Chen BT, Dumas JA, Schagen SB, Sunaert S, Wang L, Cimprich B, Peltier S, Dittus K, Newhouse PA, Silverman DH, Schroyen G, Deprez S, Saykin AJ, McDonald BC, 2023, Brain gray matter reduction and premature brain aging after breast cancer chemotherapy: a longitudinal multicenter data pooling analysis. Brain Imaging Behav, 10.1007/s11682-023-00781-7. PubMed PMID: 37256494.
  • Chen BT, Jin T, Patel SK, et al. Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study. Breast Cancer Res Treat. 2019;176(1):181-189.PMID: 30989462 PMCID: PMC6551279.
  • Chen BT, Sethi SK, Jin T, et al. Assessing brain volume changes in older women with breast cancer receiving adjuvant chemotherapy: a brain magnetic resonance imaging pilot study. Breast Cancer Res. 2018;20(1):38. PMID: 29720224 PMCID: PMC5932862.
  • Chen BT, Ghassaban K, Jin T, et al. Subcortical brain iron deposition and cognitive performance in older women with breast cancer receiving adjuvant chemotherapy: a pilot MRI study. Magn Reson Imaging. 2018;54:218-224. PMID: 30076946 PMCID: PMC6298788.
  • Chen BT, Jin T, Ye N, et al. Predicting survival duration with MRI radiomics of brain metastases from non-small cell lung cancer. Front Oncol. 2021;11:621088. doi: 10.3389/fonc.2021.621088. eCollection 2021. PubMed PMID: 33747933; PubMed Central PMCID: PMC7973105.
  • Chen BT, Jin T, Ye N, et al. Radiomic prediction of mutation status based on MR imaging of lung cancer brain metastases. Magn Reson Imaging. 2020;69:49-56. PMID: 32179095.
  • Chen BT, Chen Z, Ye N, et al. Differentiating peripherally-located small cell lung cancer from non-small cell lung cancer using a CT radiomic approach. Front Oncol. 2020;10:593. PMID: 32391274 PMCID: PMC7188953.
  • Zhang Q, Zhao Y, Nie J, Long Q, Wang X, Wang X, Gong G, Liao L, Yi X, Chen BT. Pretreatment synthetic MRI features for triple-negative breast cancer. Clinical Radiology, 79(2):e219-e26. 2024. PubMed PMID: 37935611.
  • Chen R, Fu Y, Yi X, Pei Q, Zai H, Chen BT. Application of radiomics in predicting treatment response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: strategies and challenges. J Oncol, 2022:1590620. PubMed PMID: 36471884; PubMed Central PMCID: PMC9719428.
  • Yi X, Liu H, Zhu L, Wang D, Xie F, Shi L, Mei J, Jiang X, Zeng Q, Hu P, Li Y, Pang P, Liu J, Peng W, Bai HX, Liao W, Chen BT. Myosteatosis predicting risk of transition to severe COVID-19 infection. Clinical Nutrition, doi: 10.1016/j.clnu.2021.05.031. PubMed PMID: 34147286; PubMed Central PMCID: PMC8180452.
  • Yi X, Xiao Q, Fu Y, Wang X, Shen L, Ding J, Jiang F, Wang J, Zhang Z, Chen BT. Association of white matter microstructural alteration with non-suicidal self-injury behavior and visual working memory in adolescents with borderline personality disorder. Psychiatry Research, 2024; 331:115619. PubMed PMID: 38048646.
  • Yi X, Fu Y, Zhang Z, Jiang F, Xiao Q, Chen BT.  Altered regional homogeneity and its association with cognitive function in adolescents with borderline personality disorder. Journal of Psychiatry and Neuroscience, 2023; 48(1):E1-e10. PubMed PMID: 36596589; PubMed Central PMCID: PMC9829058.