Skin Cancer Facts

April 3, 2026

This page was reviewed under our medical and editorial policy by Gaurav Singh, M.D., M.P.H., F.A.C.M.S., Mohs Micrographic Surgeon and Dermatologist, City of Hope® Cancer Center Chicago.

Skin cancer is the most commonly diagnosed cancer in the United States, affecting more than 3 million people a year.

What Is Skin Cancer?

Skin is an elastic organ. Its main functions include protecting internal organs, controlling body temperature, shielding the body from ultraviolet (UV) radiation from the sun and helping the body make vitamin D. Skin cancer develops when abnormal cells in the skin’s layers grow and form tumors.

The most common types of skin cancer — basal cell and squamous cell carcinomas — tend to appear on areas of the body exposed to the sun, such as the face, neck, ears and hands. However, it can appear anywhere on the body from head to toe.

Because this disease affects the skin, it’s often visible early, which may make it easier to detect and treat before it grows or spreads. Detecting skin cancer early can lead to a cure rate that approaches over 99%.

What Causes Skin Cancer?

Skin cancer is caused by DNA damage to skin cells. In most cases, this damage is caused by prolonged exposure to UV radiation from the sun or tanning beds.

Do Tattoos Cause Skin Cancer?

Trauma to the skin can lead to skin cancer, and tattooing is considered a form of trauma that does increase the risk of forming skin cancer in the area. A more significant concern is whether tattoos may make it hard to screen the skin for spots or moles that may be cancerous.

Do Sunburns Cause Skin Cancer?

Getting sunburned repeatedly raises the risk for developing skin cancer. People who get five or more sunburns have twice the risk for developing melanoma.

When UV rays damage the skin, those skin cells need time to heal. If the skin gets burned again before those cells fully heal, it may lead to cancer.

Risk Factors

Things that increase the risk for getting skin cancer are called risk factors. The main risk factor for developing skin cancer is exposure to UV radiation from:

  • Sunlight
  • Tanning beds
  • Sun lamps

Other factors that may contribute to developing skin cancer include:

  • Having a history of severe, blistering sunburns
  • Having many, or unusual, moles
  • Being a blonde or redhead
  • Having fair skin that easily freckles or sunburns
  • Having been exposed to large amounts of toxic substances such as paraffin oil, coal tar and arsenic compounds
  • Having a family history of skin cancer
  • Previously being diagnosed with skin cancer
  • Being older
  • Being male
  • Having a weakened immune system
  • Having a rare inherited condition called xeroderma pigmentosum or other genetic conditions
  • Having been exposed to radiation
  • Having scars from previous severe burns
References
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  • American Cancer Society. Basal and squamous cell skin cancer risk factors. October 31, 2023.
    https://www.cancer.org/cancer/types/basal-and-squamous-cell-skin-cancer/causes-risks-prevention/risk-factors.html
  • Skin Cancer Foundation. Sunburn & Your Skin. 2026.
    https://www.skincancer.org/risk-factors/sunburn/ 
  • American Cancer Society. What causes basal and squamous cell skin cancers? October 31, 2023. https://www.cancer.org/cancer/types/basal-and-squamous-cell-skin-cancer/causes-risks-prevention/what-causes.html 
  • American Academy of Dermatology Association. Do tattoos cause skin cancer? May 13, 2025. https://www.aad.org/public/diseases/skin-cancer/find/do-tattoos-cause-skin-cancer 
  • Centers for Disease Control and Prevention. Skin cancer basics. July 1, 2024.
    https://www.cdc.gov/skin-cancer/about/index.html 
  • Skin Cancer foundation. Skin cancer information. November 2025.
    https://www.skincancer.org/skin-cancer-information/