Edward Boas, M.D., Ph.D.

As an interventional radiologist, Edward Boas, M.D., Ph.D., performs minimally invasive cancer treatment procedures using needles and catheters, providing a less invasive alternative to surgery for many patients. This involves guiding a needle or a catheter toward a tumor using computed tomography, ultrasound or X-rays, then burning or freezing the tumor (ablation), blocking its blood supply (embolization) or implanting microscopic radioactive particles to treat it (radioembolization). These procedures can be used to treat cancer in the lung, liver and kidney. He also reopens blood vessels that are blocked or narrowed by a blood clot or a tumor, using minimally invasive techniques that are performed through a catheter. 
 
Dr. Boas has performed thousands of image-guided procedures and uses a multidisciplinary clinical approach, which involves coordinating care with surgeons, oncologists and other specialists to decide the best treatment strategy for each patient. Dr. Boas teaches other doctors how to perform these procedures at national meetings, and he is a reviewer for several medical journals. 
 
Dr Boas is currently running a phase II clinical trial of lung chemoembolization, which is a new treatment option for lung cancer that is not responding to systemic therapy. Rather than injecting chemotherapy into a vein, the chemotherapy is delivered directly into the tumor, which potentially reduces side effects and improves efficacy.  City of Hope is currently the only site in the US offering this localized chemotherapy treatment for non-small cell lung cancer. 
 
Dr Boas' also runs the Interventional Oncology Bioengineering Laboratory, which develops new minimally invasive therapies for liver, pancreatic, and lung cancer.  The lab is focused on local immunotherapy / in situ cancer vaccination, which is a new method for training the immune system to recognize and destroy cancer cells
 

• 2022, JVIR Editor’s Award for Outstanding Laboratory Investigation
• 2020, The Academy Imaging Shark Tank, best pitch
• 2015, 2016, 2019, Certificate of Recognition for Excellence in Teaching, Department of Radiology, Memorial Sloan Kettering Cancer Center
• 2013, Radiological Society of North America Roentgen Resident/Fellow Research Award
• 2013, American Roentgen Ray Society Residents in Radiology Executive Council Award

• Boas FE, Salgia R, Waddington T, Massarelli E, Park JJ, Kessler J, Frankel P, Alexander ES, Solomon SB.  (2023)  “Phase II trial of lung chemoembolization.”  Journal of Vascular and Interventional Radiology.  In press.  

• Pedersoli F, Boas FE, Park JJ.  (2023)  “Temporary Vascular Occlusion with Retrievable Microvascular Plugs to Protect Normal Liver During Yttrium-90 Radioembolization.”  Journal of Vascular and Interventional Radiology.  34: 978-82.  

• Boas FE.  (2023)  “Systems and methods related to dosimetry for radioembolization, chemoembolization, and drug eluting embolization procedures.”  US Prov. Appl.  Assignee: COH.  
• Maxwell AWP, Mendoza HG, Sellitti MJ, Camacho JC, Deipolyi AR, Ziv E, Sofocleous CT, Yarmohammadi H, Maybody M, Humm JL, Schwartz J, Juluru K, Dunphy MP, Boas FE.  (2022)  “Optimizing 90Y particle density improves outcomes after radioembolization.” Cardiovascular and Interventional Radiology.  45: 958-69.  
• Ghosn M, Cheema W, Zhu A, Livschitz J, Maybody M, Boas FE, Santos E, Kim DH, Beattie JA, Offin M, Rusch VW, Zauderer MG, Adusumilli PS, Solomon SB.  (2022)  “Image-Guided Interventional Radiological Delivery of Chimeric Antigen Receptor (CAR) T Cells for Pleural Malignancies in a Phase I/II Clinical Trial.”  Lung Cancer.  165: 1-9.  
• Ghosn M, Kingham P, Ridouani F, Santos E, Yarmohammadi H, Boas FE, Covey AM,  Brody LA, Jarnagin WR, D'Angelica MI, Kemeny NE, Solomon SB, Camacho JC.  (2022) “Percutaneous liver venous deprivation: outcomes in heavily pretreated metastatic colorectal cancer patients.”  HPB.  24(3): 404-12.
• Youssef EW, Ghosn M, El Hawari M, Fine GC, Maybody M, Yarmohammadi H, Brown KT, Boas FE.  (2022)  “Portal vein stent placement for malignant portal vein occlusion.”   JVIR 33(6): S98-S99.  
• Boas FE.  (2022)  “Embolization for lung tumors.”  In Fong Y, Covey A, Ahmed M, Kessler J, Iannitti D, and Dupuy D (Eds.), Interventional Oncology: Multidisciplinary Approach to Image-Guided Cancer Therapy, 2nd ed.  Springer Nature.  In press.  
• Boas FE and Solomon SB.  (2022)  “Postoperative complications requiring intervention: Diagnosis and management.”  In WR Jarnagin (Ed.), Blumgart’s Surgery of the Liver, Biliary Tract and Pancreas, 7th ed.  New York, NY: Elsevier.  
• Boas FE, Kemeny NE, Sofocleous CT, Yeh R, Thompson VR, Hsu M, Moskowitz CS, Ziv E, Yarmohammadi H, Bendet A, Solomon SB.  (2021)  “Bronchial or Pulmonary Artery Chemoembolization for Unresectable and Unablatable Lung Metastases: A Phase I Clinical Trial.”  Radiology.  301(2): 474-84.  
• Kurilova I, Bendet A, Petre EN, Boas FE, Kaye E, Gonen M, Covey A, Brody LA, Brown KT, Kemeny NE, Yarmohammadi H, Ziv E, D'Angelica MI, Kingham TP, Cercek A, Solomon SB, Beets-Tan RGH, Sofocleous CT.  (2021)  “Factors Associated With Local Tumor Control and Complications After Thermal Ablation of Colorectal Cancer Liver Metastases: A 15-year Retrospective Cohort Study.”  Clinical Colorectal Cancer 20(2): e82-95.  
• Lacayo EA, Velayati S, Elsakka A, Brody L, Erinjeri JP, Ziv E, Boas FE, Sofocleous CT, Silk M, Makker V, Tew WP, Yarmohammadi H.  (2021)  “Safety and efficacy of arterially directed liver therapies in treatment of hepatic metastatic ovarian cancer: A retrospective single-institution study.”  Journal of Vascular and Interventional Radiology.  32(6): 853-60.  
• Ridouani F, Soliman MM, England R, Hsu M, Moskowitz CS, Doustaly R, Sofocleous C, Boas FE, Yarmohammadi H, Deipolyi A.  (2021)  “Relationship of radiation dose to efficacy of radioembolization of liver metastasis from breast cancer.”  European Journal of Radiology.  136: 109539.  
• Kurilova I, Bendet A, Fung EK, Petre EN, Humm JL, Boas FE, Crane CH, Kemeny N, Kingham TP, Cercek A, D’Angelica MI, Beets-Tan RGH, Sofocleous CT.  (2021)  “Radiation segmentectomy of hepatic metastases with Y-90 glass microspheres.”  Abdominal Radiology.  46(7): 3428-36.  
• Nurili F, Monette S, Michel AO, Bendet A, Basturk O, Askan G, Cheleuitte-Nieves C, Yarmohammadi H, Maxwell AWP, Ziv E, Schachtschneider KM, Gaba RC, Schook LB, Solomon SB, Boas FE.  (2021)  “Transarterial embolization of liver cancer in a transgenic pig model.”  Journal of Vascular and Interventional Radiology.  32(4): 510-7.  
• Drabkin MJ, Bajwa R, Perez-Johnston R, Bryce Y, Boas FE, Siegelbaum R, Durack JC, Kishore S.  (2021)  “Anticoagulation reduces iliocaval and iliofemoral stent thrombosis in patients with cancer stented for nonthrombotic venous obstruction.”  Journal of Vascular Surgery: Venous and Lymphatic Disorders.  9(1): 88-94.  
• Boas FE, Nurili F, Bendet A, Cheleuitte-Nieves C, Basturk O, Askan G, Michel AO, Monette S, Ziv E, Sofocleous CT, Maxwell AWP, Schook LB, Solomon SB, Kelsen DP, Scherz A, Yarmohammadi H.  (2020)  “Induction and characterization of pancreatic cancer in a transgenic pig model.”  PLOS ONE.  15(9): e0239391.  
• Ziv E, Zhang Y, Kelly L, Nikolovski I, Boas FE, Erinjeri JP, Cai L, Petre EN, Brody L, Covey A, Getrajdman G, Harding JJ, Sofocleous C, Abou-Alfa GK, Solomon SB, Brown KT, Yarmohammadi H.  (2020)  “NRF2 dysregulation in hepatocellular carcinoma and ischemia: A cohort study and laboratory investigation.”  Radiology.  297(1): 225-34.  
• Gaba RC, Elkhadragy L, Boas FE, Chaki S, Chen HH, El-Kebir M, Garcia KD, Giurini EF, Guzman G, LoBianco FV, Neto MF, Newson JL, Qazi A, Regan M, Rund LA, Stewart M, Thomas FM, Whiteley HE, Wu J, Schook LB, Schachtschneider KM.  (2020)  “Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation.”  Oncotarget.  11: 2686-2701.  
• Deipolyi AR, England RW, Ridouani F, Riedl CC, Kunin HS, Boas FE, Yarmohammadi H, Sofocleous CT.  (2020)  “PET/CT imaging characteristics after radioembolization of hepatic metastasis from breast cancer.”  Cardiovascular and Interventional Radiology.  43(3): 488-94.  
• Sutton C, Zhang Y, Kim D, Yarmohammadi H, Ziv E, Boas FE, Sofocleous CT, Tap WD, D'Angelo SP, Erinjeri JP.  (2020)  “Analysis of the chemotherapy-free interval following image-guided ablation in sarcoma patients.”  Sarcoma.  2020: 3852420.  
• Borgheresi A, Covey A, Yarmohammadi H, Boas FE, Ziv E, Getrajdman G, Erinjeri J, Jarnagin W, Harding JJ, D'Angelica M, Gonen M, Brown KT.  (2020) “Embolization with microspheres alone for hepatocellular carcinoma with portal vein tumor: Analysis of outcome and liver function at disease progression.”  HPB.  22(4): 588-94.  
• Boas FE and Sofocleous CT.  (2020)  “Embolotherapy for the management of liver malignancies other than hepatocellular carcinoma.”  In Mauro MA, Murphy KP, Thomson KR, Venbrux AC, and Morgan RA (Eds.), Image-Guided Interventions, 3rd ed., Expert Radiology Series.
• Velayati S, Erinjeri JP, Brody LA, Ziv E, Boas FE, Brown KT, Covey AM, Getrajdman GI, Solomon SB, Kingham PT, Tap WD, Jarnagin WR, Yarmohammadi H.  (2019) “Safety and efficacy of hepatic artery embolization in treating solitary fibrous tumor metastatic to the liver.”  Sarcoma.  Article ID 3060658.  
• Boas FE, Brown KT, Ziv E, Yarmohammadi H, Sofocleous CT, Erinjeri JP, Harding JJ, Solomon SB.  (2019)  “Aspirin is associated with improved liver function after embolization of hepatocellular carcinoma.”  AJR.  213: 689-95.  
• Zener R, Yoon H, Ziv E, Covey A, Brown KT, Sofocleous CT, Thornton RH, Boas FE.  (2019)  “Outcomes after transarterial embolization of neuroendocrine tumor liver metastases using spherical particles of different sizes.”  Cardiovascular and Interventional Radiology.  42: 569-76.  
• Maybody M, Muallem N, Brown KT, Moskowitz CS, Hsu M, Zenobi CL, Jihad M, Getrajdman GI, Sofocleous CT, Erinjeri JP, Covey AM, Brody LA, Yarmohammadi H, Deipolyi AR, Bryce Y, Alago W, Siegelbaum RH, Durack JC, Gonzalez-Aguirre AJ, Ziv E, Boas FE, Solomon SB. (2019) “Autologous blood patch injection versus hydrogel plug in CT-guided lung biopsy: A prospective randomized trial.”  Radiology.  290: 547-54.  
• Kurilova I, Beets-Tan RGH, Flynn J, Gönen M, Ulaner G, Petre EN, Boas FE, Ziv E, Yarmohammadi H, Klompenhouwer EG, Cercek A, Kemeny NA, Sofocleous CT.  (2019)  “Factors Affecting Oncologic Outcomes of 90Y Radioembolization of Heavily Pre-Treated Patients With Colon Cancer Liver Metastases.”  Clinical Colorectal Cancer.  18(1): 8-18.  
• Boas F, Nurili F, Erinjeri J, Schook L, Solomon S, Yarmohammadi H. (2019) “Local immunotherapy: Intra-arterial liver tumor vaccination in a pig model of metastatic pancreatic cancer.”   JVIR 30(3S): S98-9.