Javier Arias-Stella, M.D.

Javier Arias-Stella III, M.D. carries a famous name and formidable legacy.

 

His grandfather, a renowned pathologist who served as Peru's health minister and foreign minister, discovered the “Arias-Stella phenomenon” which explained that a reaction previously misdiagnosed as cancer was actually a normal reaction of hormones in the placenta. Dr. Arias Stella's father is CEO of the Arias-Stella Institute, the largest pathology lab in Peru.

 

Dr. Arias-Stella inherited his family's fascination with pathology. “I am passionate about surgical and molecular pathology,” he says, “because it helps in understanding the pathophysiology of diseases and our input can help patients in diagnosis and management.”

 

Educated in Peru and the U.S., Dr. Arias-Stella earned his medical degree at Universidad de San Martin de Porres in Lima. He continued his training at Henry Ford Hospital in Detroit, and Memorial Sloan Kettering Cancer Center in New York City.
 

Arias-Stella JA III, Kezlarian B, Favazza L, Schultz D, Chitale DA. Programmed cell death ligand 1 (PD-L1) expression in estrogen receptor positive (ER+) invasive breast cancers: A pilot study of 148 cases. Platform presentation at United States and Canadian Academy of Pathology, 2016 Annual Meeting, Seattle, WA. 

 

Arias-Stella JA III, Rayes O, Saulino D, Williamson SR, Gupta NS. Metastatic Renal Cell Carcinoma: Correlation with Grade, Stage and Histologic Characteristics of the Primary Renal Mass - A 15 year study. Henry Ford Hospital, 23th Annual Medical Education Research Forum, 2016

 

Arias-Stella JA III, Shah AB, Montoya-Cerrillo D, Williamson SR, Gupta NS. Prostate Biopsy and Radical Prostatectomy Gleason Score Correlation in Heterogeneous Tumors: Proposal for a Composite Gleason Score. Henry Ford Hospital, 22nd Annual Medical Education Research Forum, 2015 – Second place. Michigan Society of Pathologists, winter conference, 2014 – Second place

 

Arias-Stella JA III, Cheesman A, Benza N, Bedoya M, Gallastegui N. Clinical & pathological correlation on 455 autopsies carried out at the Arias Stella Institute of Pathology and Molecular Biology. Metodologia de la Investigacion, Universidad de San Martin de Porres; 2005; Lima, Peru.

 

 

Hugo Carrillo-Ng, Yu Liang, Sue Chang, Michelle Afkhami, Thomas Gernon, Diana Bell, Javier A Arias-Stella. Complete mimicry: Rhabdomyosarcoma with FUS::TFCP2 fusion masquerading as carcinoma-diagnostic challenge and report of two cases. Genes Chromosomes Cancer. 2023 Jul;62(7):430-436. PMID: 37057803

 

Collecting Duct Carcinoma of the Kidney: Diagnosis and Implications for Management. Cabanillas G, Montoya-Cerrillo D, Kryvenko ON, Pal SK, Arias-Stella JA III. Urologic Oncology: Seminars and Original Investigations. Accepted for publication, 2021.

 

Novel PLAG1 Gene Rearrangement Distinguishes a Subset of Uterine Myxoid Leiomyosarcoma From Other Uterine Myxoid Mesenchymal Tumors.Arias-Stella JA 3rd, Benayed R, Oliva E, Young RH, Hoang LN, Lee CH, Jungbluth AA, Frosina D, Soslow RA, Antonescu CR, Ladanyi M, Chiang S.Am J Surg Pathol. 2019 Mar;43(3):382-388. PMID: 30489320

 

Lewis N, Soslow RA, Delair DF, Park KJ, Murali R, Hollmann TJ, Davidson B, Micci F, Panagopoulos I, Hoang LN, Lee, C-H, Arias-Stella AJ III, Oliva E, Young RH, Hensley ML, Leitao Jr., MM, Hameed M, Benayed R, Ladanyi M, Frosina D, Jungbluth AA, Antonescu CR, hiang S. ZC3H7B-BCOR High-Grade Endometrial Stromal Sarcomas: A Report of 17 Cases of a Newly Defined Entity. Accepted for publication, Modern Pathology, MP-2017-0769-R. 

 

Arias-Stella JA III, Shah AB, Gupta NS, Williamson SR. "CK20 and p53 Immunohistochemical Staining Patterns in Urinary Bladder Specimens with Equivocal Atypia: Correlation with Outcomes" Arch Pathol Lab Med. 2017 Oct 2. [Epub ahead of print] PMID:28967804

 

Chiang S, Lee CH, Stewart CJR, Oliva E, Hoang LN, Ali RH, Hensley ML, Arias-Stella JA 3rd, Frosina D, Jungbluth AA, Benayed R, Ladanyi M, Hameed M, Wang L, Kao YC, Antonescu CR, Soslow RA. BCOR is a robust diagnostic immunohistochemical marker of genetically diverse high-grade endometrial stromal sarcoma, including tumors exhibiting variant morphology. Mod Pathol. 2017 Sep;30(9):1251-1261. Epub 2017 Jun 16. PMID: 28621321

 

Saste AB, Jiang F, Arias-Stella JA III, Gamalski S, Peres E, Janakiraman N, Farhan S. Emberger Syndrome with Concomitant GATA2, NPM1 and FLT3-ITD Mutations in Remission after Allogeneic Stem Cell Transplant. Biol Blood Marrow Transplant. 2016 Mar 22(3):S208-S209  

 

Saste A, Arias-Stella JA III, Kuriakose P. Progression of a hepatosplenic gamma delta T-cell leukemia/lymphoma on hyperCVAD/MTX and ara-C: literature review and our institutional treatment approach. Clin Case Rep. 2015 Nov 23;4(1):67-71. PMID: 26783439

 

Arias-Stella JA III, Shah AB, Montoya-Cerrillo D, Williamson SR, Gupta NS. Prostate Biopsy and Radical Prostatectomy Gleason Score Correlation in Heterogeneous Tumors: Proposal for a Composite Gleason Score. Am J Surg Pathol. 2015 Sep;39(9):1213-8. PMID:26274028

 

Arias-Stella JA III, Varma K, Montoya-Cerrillo D, Gupta NS, Williamson SR. Does discontinuous involvement of a prostatic needle biopsy core by adenocarcinoma correlate with the presence of a large tumor focus at radical prostatectomy? Am J Surg Pathol. 2015 Feb;39(2):281-6. PMID: 25353288

 

Joel N. Phillips, DO; Elmotaz Ibrahim, MD; Javier A. Arias-Stella III, MD; Mirela Cerghet, MD; Naganand Sripathi, MD. Acute Myeloid Leukemia Presenting as Autoimmune Autonomic Ganglionopathy. Neurological Cases, Vol1 No2; December 2014. ISSN 2374-3522 (Print) 

 

Kryvenko ON, Chitale DA, Yoon J, Arias-Stella J III, Meier FA, Lee MW. Precursor lesions of mucinous carcinoma of the breast: analysis of 130 cases. Am J Surg Pathol. Jul 2013;37(7):1076-1084.

Rivara Dávila G, Bucher Oliva A, Briceño Clemens D, Huaipar Rodriguez S, Liu Bejarano C, De Souza Ferreira Hunt K, Nuñez Hernández E, Dammert Schreier M, Gallástegui Crestani N, Arias Stella JA III, Cheesman Rocca A, Naranjo Vegas J, Patsias Osório A, Rosell Alayza A, Vela Gonzales Y, San Martín Llosa S, Scerpella Crespo L, Seminario Vargas A, Silva Montoya D, Sinchi Tuesta M, Zambrano E, Huando R. Clowns as analgesic pharmacological method in hospitalized children. Rev Peru Pediatr. 2010;63(2):9-19.

 

Arias-Stella JA III, Ganesan R, Kong CS, Mirkovic J, Moritani S. 

 

Arias-Stella reaction of the uterine cervix. Benign glandular lesions, p 360. Tumours of the uterine cervix, Female Genital Tumours, WHO Classification of Tumours, 5th Ed, 2020. 

 

Arias-Stella JA III, Pareja FG. “Special types of invasive breast carcinoma” (chapter 15), Practical Atlas of Breast Pathology, edited by Dr. Simona Stolnicu and Dr. Isabel Alvarado-Cabrero, to be published by Springer in 2018.  

 

Arias-Stella JA III, Williamson SR. Updates in Benign Lesions of the Genitourinary Tract. Surg Pathol Clin. 2015 Dec;8(4):755-87. PMID: 26612226

 

Arias-Stella JA III, Ryma B, Hoang L, Lee CH, Jungbluth A, Soslow RA, Esther O, Young RH, Antonescu CR, Ladanyi M, Chiang S. Novel PLAG1 Gene Rearrangement Distinguishes Uterine Myxoid Leiomyosarcoma from Other Uterine Myxoid Mesenchymal Tumors. Abstract accepted at United States & Canadian Academy of Pathology’s 107th Annual Meeting in Vancouver, British Columbia, Canada, March 17-23, 2018.

 

Arias-Stella JA III, Rana S, Gounder M, Ladanyi M, Dogan S. Pathogenic SMARCA4 Mutations in Head and Neck and Thyroid Carcinomas are Rare. Abstract accepted at the United States & Canadian Academy of Pathology’s 107th Annual Meeting in Vancouver, British Columbia, Canada, March 17-23, 2018.

 

Arias-Stella JA III, Kezlarian B, Favazza L, Schultz D, Chitale DA. Programmed cell death ligand 1 (PD-L1) expression in estrogen receptor positive (ER+) invasive breast cancers: A pilot study of 148 cases. Platform presentation at United States and Canadian Academy of Pathology, 2016 Annual Meeting, Seattle, WA. 

 

Kezlarian B, Favazza L, Arias-Stella JA III, Schultz D, Chitale DA. Does tumor infiltrating lymphocyte (TIL) count influence oncotype DX recurrence score and Magee equation scores?. Poster presentation at United States and Canadian Academy of Pathology, 2016 Annual Meeting, Seattle, WA.

 

Arias-Stella JA III, Shah AB, Gupta NS, Williamson SR. CK20 and p53 immunohistochemistry: Staining patterns and follow up in urinary bladder specimens with urothelial atypia. Poster presentation at United States and Canadian Academy of Pathology, 2016 Annual Meeting, Seattle, WA.

 

Shah SB, Gadde R, Arias-Stella JA III, Williamson SR, Gupta NS. Radical prostatectomy outcomes of prostatic adenocarcinoma diagnosed after initial diagnosis of atypical glands on prostate needle biopsy. Poster presentation at United States and Canadian Academy of Pathology, 2016 Annual Meeting, Seattle, WA.

 

Arias-Stella JA III, Rayes O, Saulino D, Williamson SR, Gupta NS. Metastatic Renal Cell Carcinoma: Correlation with Grade, Stage and Histologic Characteristics of the Primary Renal Mass - A 15 year study. Poster presentation at United States and Canadian Association of Pathology, 2015 annual meeting; Boston, MA.

 

Varma KR, Arias-Stella JA III, Meier F, Luzzi V. Bio-Rad in2it hemoglobin A1c percentage lot-dependent analytic variation. Arch Pathol Lab Med. 2014;138(9):e173-e174. 

 

Phillips J, Ibrahim E, Cerghet M, Arias-Stella JA III, Sripathi N. AML presenting as autonomic autoimmune ganglionopathy. Poster presented at: 66th American Academy of Neurology Annual Meeting; April 26-May 3, 2014; Philadelphia, PA.
 
Arias-Stella JA, Gulati R, Montoya-Cerrillo D, Williamson SR, Gupta NS. Composite Gleason score (CGS) is superior to grading individual needle cores when more than two grades are present in a 12 core prostate biopsy: a study of 118 cases. Mod Pathol. 2014;27:214A-215A.

 

Arias-Stella JA, Varma K, Montoya-Cerrillo D, Gupta NS, Williamson SR. Does discontinuous involvement of a prostatic needle biopsy core by adenocarcinoma correlate with the presence of a large tumor focus at radical prostatectomy? Mod Pathol. 2014;27:214A.

 

Arias-Stella JA, Williamson SR, Gupta NS. Is the 2005 International Society of Urological Pathology (ISUP) recommendation for Gleason grading accurate when three different Gleason grade patterns are present in the same needle core? Mod Pathol. 2014;27:215A.

 

Arias-Stella JA, Arbach D, Tibbetts R, Stone CH. Aspergillus pulmonary infection with pigmentation on histopathology section: two case reports. Poster presented at: College of American Pathologists 2013 Annual Meeting; October 13-16, 2013; Orlando, FL.

 

Arias-Stella J, Feldkamp C, Zajechowski J, Stezar L, Luzzi VI. Analytical performance of the SYVA EMIT 2000 Tacrolimus assay on the Beckman DxC 800. Clin Chem. 2013;59(S10):A133. 

 

Arias-Stella J, Zajechowski J, Stezar L, Cosman M, Swiderski D, Feldkamp C, Luzzi VI. Analytical performance of the premier Hb9210 for HbA1c measurement. Clin Chem. 2013;59(S10):A97-A98.
 
Gomez-Gelvez J, Chabot D, Arias-Stella J, Foucar K, Inamdar K, Karner K. Use of virtual microscopy for the examination of peripheral blood smears at remote locations. Mod Pathol. 2013;26:493A.

 

Gomez-Gelvez J, Chabot D, Arias-Stella J, Foucar K, Inamdar K, Karner K. Evaluation of virtual microscopy compared with conventional light microscopy for the examination of peripheral blood smears. Poster presented at: Michigan Society of Pathologist Winter Conference; December 2012; Plymouth, MI.

 

Arias-Stella JA III, Cheesman A, Benza N, Trivella J, Suarez V, Arias-Stella J Jr. Immunohistochemistry profiles for MLH1, MSH2 and MSH6 in 91 cases of colon cancer in Lima, Peru. Oral presentation at: Harvard Medical School New England Science Symposium; April 2012; Boston, MA.

 

Kryvenko ON, Yoon J, Arias-Stella J, Lee MW, Chitale DA. Morphologic & immunohistochemical heterogeneity in mucinous carcinoma of breast (MC). Mod Pathol. 2012;25:48A.

 

Kryvenka ON, Chitale DA, Yonn J, Arias-Stella J, Lee MW. Primary mucinous carcinoma (MC) of breast - a proposal of precursor lesion & possible tumor progression. Mod Pathol. 2012;25:48A.