Leonidas Arvanitis, M.D.
Pathologist
Clinical Expertise
Digestive System Pathology
Neuropathology
Thoracic Pathology
Other Languages Spoken
Appointments
Associate Clinical Professor, Department of Pathology
Duarte Cancer Center
1500 East Duarte Road
Duarte, CA 91010
Duarte, CA 91010
Anatomical and Clinical Pathology, American Board of Pathology, MOC
Neuropathology, American Board of Pathology, MOC
2005, M.D., University of Thessaly, School of Medicine, Larissa, Greece
2012-2014, Clinical Fellow in Neuropathology, University of Pittsburgh Medical Center, Pittsburgh, PA
2005-2008, Pathology, University of Thessaly, School of Medicine, Larissa, Greece
2008-2012, Anatomic and Clinical Pathology, Rush University Medical Center, Chicago, IL
2023-present, Associate Clinical Professor, Department of Pathology, City of Hope, Duarte, CA
2017-2023, Assistant Clinical Professor, Department of Pathology, City of Hope, Duarte, CA
2014-2017, Assistant Professor of Pathology, Director of Neuropathology and Autopsy Service, Rush University Medical Center, Chicago, IL
- Zhao D, Li H, Mambetsariev I, Mirzapoiazova T, Chen C, Fricke J, Kulkarin P, Villaflor V, Arvanitis L, Hamilton S, Afkhami M, Oillai R, Armstrong B, Erhunmwunsee L, Massarelli E, Sattler M, Amini A, Salgia R. Clinical and Molecular Features of KRAS Mutated Lung Cancer Patients Treated with Immune Checkpoint Inhibitors. Cancers 2022, 14(19), 4933
- Sun T, Zhang K, Li W, Liu YZ, Pangeni RP, Arvanitis L, Raz DJ. Transcription Factor AP2 enhances malignancy of non-small cell lung cancer through upregulation of USP22 gene expression. Cell Commun Signal 20, 147 (2022).
- Kethireddy N, Arvanitis L, LoBello J, Woo Y, Szelinger S, Chao J. A Case Report of Immunotherapy-Resistant MSI-H Gastric Cancer with Significant Intrapatient Tumoral Heterogeneity Characterized by Histologic Dedifferentiation. J. Clin. Med. 2022, 11(12), 3413
- Mambetsariev I*, Arvanitis L*, Fricke J, Pharaon R, Baroz AR, Afkhami M, Koczywas M, Massarelli E, Salgia R. Small Cell Lung Cancer Transformation Following Treatment in EGFR-Mutated Non-Small Cell Lung Cancer. J.Clin.Med. 2022, 11, 1429 *co-first author
- Mirzapoiazova T, Xiao G, Mambetsariev B, Nasser MW, Miaou E, Singhal SS, Srivastava S, Mambetsariev I, Nelson MS, Nam A, Behal A, Arvanitis LD, Atri P, Müschen M, Tissot FLH, Miser J, Kovach JS, Sattler M, Batra SK, Kulkarni P, Salgia R. Protein phosphatase 2A as a therapeutic target in small cell lung cancer. Mol Cancer Ther. 2021 Jul 12:molcanther.0013.2021. doi: 10.1158/1535-7163.MCT-21-0013. Epub ahead of print. PMID: 34253596.
- Roosan MR, Mambetsariev I, Pharaon R, Fricke J, Baroz AR, Chao J, Chen C, Nasser MW, Chirravuri-Venkata R, Jain M, Smith L, Yost SE, Reckamp KL, Pillai R, Arvanitis LD, Afkhami M, Wang EW, Chung V, Cristea M, Fakih M, Koczywas M, Massarelli E, Mortimer J, Yuan Y, Batra SK, Pal S, Salgia R. Evaluation of Somatic Mutations in Solid Metastatic Pan-Cancer Patients. Cancers (Basel). 2021 Jun 3;13(11):2776. doi: 10.3390/cancers13112776. PMID: 34204917; PMCID: PMC8199748.
- Reckamp KL, McQuerry JA, Mambetsariev I, Pharaon R, Yost SE, Fricke J, Mirzapoiazova T, Pillai RK, Arvanitis L, Khan Z, Fakih M, Yuan Y, Koczywas M, Massarelli E, Kulkarni P, Pal SK, Sattler M, Bild A, Salgia R: Co-stimulatory and co-inhibitory immune markers in solid tumors with MET alterations. Future Science OA 2020, 7:FSO662.
- Sun T, Zhang K, Pangeni RP, Wu J, Li W, Du Y, Guo Y, Chaurasiya S, Arvanits L, Raz DJ. G9a promotes invasion and metastasis of non-small cell lung cancer through enhancing focal adhesion kinase activation via NF-κB signaling pathway. (Accepted Molecular Cancer Research 2020)
- Mohanty A, Nam A, Pozhitkov A, Yang L, Srivastava S, Nathan A, Wu X, Mambetsariev I, Nelson M, Subbalakshmi A, Arvanitis LD, Nasser MW, Batra SK, Orban J, Humar Jolly M, Massarelli E, Kulkarni P, Salgia R. A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer. iScience. 2020;23(9):101496
- Nikolaou M, Drosos Y, Havaki S, Sotiriou S; Vassiou K; Zibis A, Arvanitis L. The O-Linked N-Acetylglucosamine Containing Epitope H (O-GlcNAcH) is Upregulated in the Trophoblastic and Downregulated in the Fibroblastic Cells in Missed Miscarriage Human Chorionic Villi with Simple Hydropic Degeneration. Int J Gynecol Pathol. 2020 Sep 4. doi: 10.1097/PGP.0000000000000693. Epub ahead of print. PMID: 32897971.
- Dizman N, Salgia M, Ali SM, Arvanitis L, et al. Squamous Transformation of Prostate Adenocarcinoma: A Report of Two Cases With Genomic Profiling. Clin Genitourin Cancer. 2020;18(3):e289-e292. doi:10.1016/j.clgc.2019.11.020
- Rodriguez FJ, Brosnan-Cashman JA, Allen SJ, Vizcaino MA, Giannini C, Camelo-Piragua S, Webb M, Matsushita M, Wadhwani N, Tabbarah A, Hamideh D, Jiang L, Chen L, Arvanitis LD, Alnajar HH, Barber JR, Rodríguez-Velasco A, Orr B, Heaphy CM.Alternative lengthening of telomeres, ATRX loss and H3-K27M mutations in histologically defined pilocytic astrocytoma with anaplasia. Brain Pathol. 2019 Jan;29(1):126-140. doi: 10.1111/bpa.12646. Epub 2018 Oct 17. PubMed PMID: 30192422; PubMed Central PMCID: PMC6314894.
- Alnajar H, Brickman A, Buckingham L, Arvanitis LD. Metastatic malignant PEComa of the leg with identification of ATRX mutation by next-generation sequencing. Virchows Arch. 2018 Mar;472(3):499-503. doi: 10.1007/s00428-017-2208-x. Epub 2017 Jul 28. PubMed PMID: 28755029.
- Novo J, Lin D, Shanks M, Kocak M, Arvanitis L. A 55-year-old female with leukoencephalopathy with cerebral calcifications and cysts: Case report and radiopathologic description. Pathol Res Pract. 2017 Nov;213(11):1440-1444. doi: 10.1016/j.prp.2017.07.007. Epub 2017 Jul 6. PubMed PMID: 28756984.