Mustafa Raoof, M.D., M.S.
Surgical Oncologist
5 (115 RATINGS)
Clinical Expertise
- Gallbladder and Bile Duct Surgery
- Liver (Hepatobiliary) Surgery
- Pancreatic Surgery
- HIPEC — Hyperthermic (or Heated) Intraperitoneal Chemotherapy
- PIPAC — Pressurized Intraperitoneal Aerosol Chemotherapy
- Robotic Surgery for Liver and Pancreatic Tumors
- Surgery for Retroperitoneal Sarcomas and Gastrointestinal Stromal Tumors
- Surgery for Neuroendocrine Tumors
- Surgical Oncology
Research Area
- Replication Stress and DNA Damage Response in Gastrointestinal Cancers
- Immunology and Immune Therapies for Gastrointestinal Cancers
- Nanoparticles for Targeted Drug Delivery in Peritoneal Surface Malignancies
Other Languages Spoken
Hindi
Punjabi
Urdu
Academic Appointments
- Associate Professor, Department of Surgery
- Associate Professor, Department of Cancer Genetics and Epigenetics
Clinical Teams
Bile Duct Cancer
Gallbladder Cancer
Gastrointestinal Cancers
HIPEC — Hyperthermic (or Heated) Intraperitoneal Chemotherapy
Liver Cancers and Liver Tumors
Pancreatic Cancer
Surgery
Research Teams
Molecular and Cellular Biology
Additional Contacts
- Referring Physicians/Colleagues(626) 218-5484
Becoming a physician enables you to help patients and make a difference in their lives, not just by providing high quality health care, but also by being a researcher, educator and an advocate.
A talented surgical oncologist and scientist, Mustafa Raoof, M.D., M.S., joined City of Hope in 2015, where he focuses on the surgical treatment of cancers within the abdominal cavity, particularly those from the liver, bile ducts, pancreas and the gastrointestinal tract. Additionally, Dr. Raoof has expertise in treating cancers that have spread to involve the liver or the peritoneum.
At City of Hope, Dr. Raoof is part of one of the largest programs in the region performing complex cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for cancers that have disseminated within the abdominal cavity. He also has vast experience in providing all aspects of surgical care to patients whose cancer has spread to the liver.
In addition to clinical practice, Dr. Raoof conducts laboratory research focusing on DNA repair mechanisms in cancers. He is particularly interested in pancreatic cancer that has been very challenging to treat. By identifying and characterizing DNA repair processes that help cancer cells escape the toxic effects of chemotherapy, he is working to develop better targets for future therapies.
Dr. Raoof received his medical degree from Pakistan's Aga Khan University, then came to the U.S. where he continued his training at Harvard University, Yale University, MD Anderson Cancer Center and University of Arizona. He is the author of dozens of peer-reviewed papers that have been published in leading scientific journals, including Nature, Journal of National Cancer Institute and Biomaterials. Dr. Raoof is the recipient of several honors and awards, most notably, the National Comprehensive Cancer Network's Young Investigator Award, and the Pancreatic Cancer Action Network's Career Development Award.
Dr. Raoof’s mission is to deliver complex surgical oncology care with expertise and compassion, as well as to develop new therapies for patients with gastrointestinal cancers. To that end, he chose City of Hope for its “culture of scientific discovery that accelerates adaptation of groundbreaking treatments to clinical cancer care.”
At City of Hope, Dr. Raoof is part of one of the largest programs in the region performing complex cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for cancers that have disseminated within the abdominal cavity. He also has vast experience in providing all aspects of surgical care to patients whose cancer has spread to the liver.
In addition to clinical practice, Dr. Raoof conducts laboratory research focusing on DNA repair mechanisms in cancers. He is particularly interested in pancreatic cancer that has been very challenging to treat. By identifying and characterizing DNA repair processes that help cancer cells escape the toxic effects of chemotherapy, he is working to develop better targets for future therapies.
Dr. Raoof received his medical degree from Pakistan's Aga Khan University, then came to the U.S. where he continued his training at Harvard University, Yale University, MD Anderson Cancer Center and University of Arizona. He is the author of dozens of peer-reviewed papers that have been published in leading scientific journals, including Nature, Journal of National Cancer Institute and Biomaterials. Dr. Raoof is the recipient of several honors and awards, most notably, the National Comprehensive Cancer Network's Young Investigator Award, and the Pancreatic Cancer Action Network's Career Development Award.
Dr. Raoof’s mission is to deliver complex surgical oncology care with expertise and compassion, as well as to develop new therapies for patients with gastrointestinal cancers. To that end, he chose City of Hope for its “culture of scientific discovery that accelerates adaptation of groundbreaking treatments to clinical cancer care.”
Location
Duarte Cancer Center
1500 East Duarte Road
Duarte, CA 91010
Duarte, CA 91010
Orange County Lennar Foundation Cancer Center
1000 FivePoint
Irvine, CA 92618
Irvine, CA 92618
Education & Experience
2016, General Surgery, American Board of Surgery
2018, Complex General Surgical Oncology, American Board of Surgery
2011-2012, M.S. Patient-Based Biological Research/Translational Sciences, Graduate School of Biomedical Sciences, University of Texas, Houston, TX
2006, B.M.M.S., Aga Khan University, Pakistan
2015-2017, Complex Surgical Oncology, City of Hope, Duarte, CA
2010-2012, Cancer Biology and Nanotechnology, MD Anderson Cancer Center, University of Texas, Houston, TX
2007-2008, Immunology, Beth Isael Deaconess Medical Center, Harvard Medical School, MA
2009-2015, General Surgery, University of Arizona, Tucson, AZ
2008-2009, General Surgery, Yale-New Haven Hospital, Yale University, New Haven, CT
Awards & Memberships
Awards
2021-2023, Pancreatic Cancer Action Network Career Development Award
2020-2022, NCCN Young Investigator Award
2019-2021, American College of Surgeons, Faculty Research Fellowship
2018-2019, Young Innovator Award, City of Hope
2017, American Society of Clinical Oncology Conquer Cancer Foundation Merit Award
2012, Young Investigator Award, Biology Informa-Yamamoto Society of Thermal Medicine
Memberships
American College of Surgeons
Society of Surgical Oncology
Americas Hepato-Pancreato-Biliary Association
American Society of Colorectal Surgeons
Society for the Surgery of Alimentary Tract
American Association for Cancer Research
Publications
Selected Publications
Damage associated molecular patterns (DAMPS) and innate immune responses
- Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 2010 464(7285):104-7.
- Raoof M, Zhang Q, Itagaki K, Hauser CJ. Mitochondrial Peptides Are Potent Immune Activators That Activate Human Neutrophils Via FPR-1. Journal of Trauma-Injury Infection and Critical Care 2010 Jun 68(6):1328-32.
Multi-functional nanomaterials for cancer therapy
- Raoof M, Mackeyev Y, Cheney MA, Wilson LJ, Curley SA. Internalization of C60 fullerenes into cancer cells with accumulation in the nucleus via the nuclear pore complex. Biomaterials 2012 Apr 33(10):2952-60
- Raoof M, Corr SJ, Kaluarachchi WD, et al. Stability of antibody-conjugated gold nanoparticles in the endo-lysosomal nanoenvironment: Implications for non-invasive radiofrequency-based cancer therapy. Nanomedicine 2012 Oct 8(7):1096-105
- Raoof M, Cisneros BT, Guven A, Phounsavath S, Corr SJ, Wilson LJ, Curley, SA. Remotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields. Biomaterials. 2013 Feb 34(7):1862-9.
- Mackeyev Y, Raoof M, Cisneros BT, Koshkina N, Berger CS, Wilson LJ, Curley SA. Toward Paclitaxel-[60]Fullerene Immunoconjugates as a targeted prodrug against cancer. Nanosystems: Physics, Chemistry, Mathematics. 2014 Jan 5(1):0–8
Development of a non-invasive radiofrequency-based nanohyperthermia system for cancer treatment
- Corr SJ, Raoof M, Mackeyev Y, Phounsavath S, Cheney MA, Cisneros BT, Shur M, Gozin M, McNally PJ, Wilson LJ, Curley SA. Citrate-capped gold nanoparticle electrophoretic heat production in response to a time-varying radiofrequency electric-field. J Phys Chem C Nanomater Interfaces. 2012 Nov 15 116(45):24380-24389
- Raoof M, Curley SA. Non-invasive radiofrequency-induced targeted hyperthermia for the treatment of hepatocellular carcinoma. Int J Hepatol 2011:676957.
- Raoof M, Cisneros BT, Corr SJ, Palalon F, Curley SA, Koshkina NV. Tumor selective hyperthermia induced by short-wave capacitively-coupled RF electric-fields. PLoS One. 2013 Jul 4 8(7):e68506
- Raoof M, Corr SJ, Zhu C, Cisneros BT, Kaluarachchi WD, Phounsavath S, Wilson LJ, Curley SA. Gold nanoparticles and radiofrequency in experimental models for hepatocellular carcinoma. Nanomedicine 2014 Aug 10(6):1121-30
DNA damage and chemotherapy resistance in liver cancer
- Raoof M, Zhu C, Cisneros BT, Liu H, Corr SJ,Wilson LJ, Curley SA. Hyperthermia inhibits homologous recombination at gemcitabine-stalled replication forks. JNCI 2014. 2014 Aug 106(8)
Ratings & Reviews
Ratings and reviews below are gathered from the Press Ganey Clinician and Group Consumer Assessment of Healthcare Providers and Systems (CG CAHPS) survey. CG CAHPS is a standardized survey that is used to measure a patient's experience in the physician office setting. Ratings are an average of all responses to questions about a provider's care, with five stars being the highest.
5.0
Recommend this provider office
5.0
Provider explain in way you understand
5.0
Provider listen carefully to you
5.0
Know important info medical history
5.0
Show respect for what you say
5.0
Spend enough time with you
4.9
Rate provider 0-10
03/23/26
Good - Verified patient
03/23/26
Care provider is very good and dynamic - Verified patient
03/10/26
Good - Verified patient
01/26/26
Dr. Raoof is excellent and very smart. - Verified patient
01/26/26
Dr. Raoof does an outstanding job of explaining and uses images of the CT scan which helps me to understand. - Verified patient