Mike Y. Chen, M.D., Ph.D.

  • Associate Professor, Division of Neurosurgery, Department of Surgery
  • Neurosurgeon

Mike Y. Chen, M.D., Ph.D.

Clinical Specialties
  • Neurosurgery
Areas of Expertise
  • Complex operations for the removal of brain, brachial plexus and spine tumors
Research Focus
  • Histone Mediated Epigenetic Regulation of Glioblastomas
  • Effect of Pulsed Electromagnetic Fields on Enhancing Chemotherapeutics Agents
  • Correlation of Hormone Receptor Status with Bone Formation in Metastatic Spine Tumors
Other Languages Spoken
  • Mandarin
Bring your best everyday and keep making it better.

A prolific researcher, talented physician and board-certified neurosurgeon, Mike Y. Chen, M.D., Ph.D., has been on the City of Hope team since 2007. Dr. Chen specializes in complex operations for the removal of brain and spine tumors. He also frequently treats benign and degenerative conditions of the spine for City of Hope patients.

As a contributor to the advancement of neurosurgery, Dr. Chen devises new surgical techniques, works with medical device companies to design new tools and teaches procedures to other surgeons.

Dr. Chen received his medical doctorate from Thomas Jefferson University. He furthered his training with an internship at Johns Hopkins University and a residency at the Medical College of Virginia in Richmond. Dr. Chen also completed a research fellowship in surgical neurology at the National Institutes of Health.


  • 2015 - present, Associate Professor, Department of Surgery, City of Hope, Duarte, CA
  • 2012 - present, Director of the Neurosurgical Oncology Fellowship Program, City of Hope, Duarte, CA
  • 2011 - 2012, President of the Society for Brain Mapping and Therapeutics
  • 2007 - 2015, Assistant Professor and Section Head of Malignant Brain Tumor Program, Division of Neurosurgery, Department of Surgery, City of Hope, Duarte, CA
  • 2006, Assistant Professor, Department of Neurosurgery, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA
  • Brain Tumors
  • Spine Tumors
  • Pediatric Brain and Spinal Tumors
  • Pituitary Disorders
  • Skin Cancer/Melanoma


City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA, 91010

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Phone :  626-256-4673


City of Hope Arcadia, 301 W. Huntington Drive, Suite 400, Arcadia, CA, 91007

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Phone :  626-218-9840


  • 2006, Doctor of Philosophy, Anatomy and Neurobiology, Virginia Commonwealth University/Medical, College of Virginia, Richmond
  • 1990, Bachelor of Science, Pennsylvania State University, State College, Pennsylvania
  • 1988 -1996, Pennsylvania State University, B.S., Thomas Jefferson University, M.D. (6 year combined B.S., M.D. program)
  • 1992-1994, Johns Hopkins University, Baltimore, MD, M.S., Biomedical Engineering


  • 1997 -2000, Research Fellowship, National Institutes of Health, Surgical Neurology Branch


  • 2000 -2006, Medical College of Virginia, / Virginia Commonwealth University Health System, Richmond, VA, Neurosurgery Residency, Ph.D., Anatomy and Neurobiology


  • 1996 -1997, Johns Hopkins Hospital, Baltimore, MD, Internship in Surgery
  • 2013, Board Certified by the American Board of Neurological Surgery
  • Margaret Early Trust Grant. Role of the Chromobox Protein CBX6 in the Mesenchymal Transition of Glioblastoma 2012. Principle Investigator
  • Biomechanical evaluation of dual vertebral cages in the thoracic spine. Investigator Initiated Research. Globus Medical Grant. 2012
  • Golden Axon Award for Leadership and Dedication. Society for Brain Mapping and Therapeutics. June 2012
  • Characterizing the progenitor cell subpopulation in cancellous bone. Nuvasive. Industry Sponsored grant: $560,000. September 2010.
  • Biomechanical assessment of thoracic and lumbar vertebral column reconstruction with bilateral expandable cages. Globus Medical Corporation. Investigator Initiated Research: $10,000. August 2010
  • Named by Pasadena Magazine as one of the top neurosurgeons in Los Angeles in 2009, 2010, 2011, 2012, 2013
  • Biomechanical assessment of C2 vertebral column reconstruction with bilateral expandable cages. Globus Medical Corporation. Industry Sponsored Grant: $10,000. January 2010
  • 2nd place at 2nd Annual COH Poster Session, “Collaboration: Synergy for Success.” The Use of Tisseel as a Delivery Vehicle for Genetically Engineered Cytotoxic T Lymphocytes. Zhaoxia Zou, M.D., Erin Denny, Christine Brown, Ph.D., Araceli Hamlett, James Wang, Ph.D., Yufang Yin, Mike Chen, M.D., Ph.D.
  • Pilot Study: Characterizing the progenitor cell subpopulation in cancellous bone Nuvasive. Industry Sponsored Grant: $160,000. February 2010
  • NASA Tech Brief Award for NTR 45433: Use of JPL Electronic Nose for Detection of Tumors. 2008
  • 2007, NIH K 12 Grant for $500,000. The effect of stat3 inhibitors distributed using convection-enhanced delivery on cell death and chemoreistance in metastatic melanomas of the murine brain.
  • 2003, Crutchfield, Gage and Thomson award for best resident presentation at the annual meeting of the Neurosurgical society of the Virginias
  • 1999, Fellows Award for Research Excellence, National Institutes of Health


  • American Association of Neurological Surgeons
  • Congress of Neurological Surgeons
  • Faculty - Irell & Manella Graduate School of Biological Sciences, City of Hope
  • International Neurosurgical Children’s Association
  • Clinical Assistant Professor of Surgery at Western University of Health Sciences
  • International Brain Mapping and Intra-operative Surgical Planning Society: Board of Directors
  • The Johns Hopkins Medical & Surgical Association
  • Los Angeles County Medical Association
  • California Medical Association
  • American Association for Cancer Research
  • Society for Neuro-Oncology
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