An NCI-designated Comprehensive Cancer Center

Shiuan Chen, Ph.D.

Chair and Professor, Department of Cancer Biology; The Lester M. and Irene C. Finkelstein Chair in Biology
Research Focus
  • Chemoprevention Research Program
  • Breast Cancer Translational Research
  • Program in Natural Therapies
Other Languages Spoken
  • Mandarin

Research Teams


City of Hope Comprehensive Cancer Center, 1500 East Duarte Road

Duarte, CA 91010

Information listed here is obtained from PubMed, a public database. City of Hope is not responsible for its accuracy. Selected Peer-reviewed Publications (Selected from 249 peer reviewed publications)

Petrossian K, Kanaya, N, Lo C, Hsu PY, Nguyen D, Yang L, Yang L, Warden C, WuX, Pillai R, Bernal L, Huang CS, Kruper L, Yuan Y, Somlo G, Mortimer J, Chen S. ER-mediated cell cycle progression is an important requisite for CDK4/6 inhibitor response in HR+ breast cancer. Oncotarget. 2018; 9(45):27736-27751. Doi: 10.18632/oncotarget.25552. PubMed [journal] PMID: 29963233 PMCID: PMC6021239

Petrossian K, Nguyen D, Lo C, Kanaya N, Somlo G, Cui YX, Huang CS, Chen S. Use of dual mTOR inhibitor MLN0128 against everolimus-resistant breast cancer. Breast cancer research and treatment. 2018; 70(3):499-506. NIHMSID: NIHMS957500 PubMed [journal] PMID: 29623577, PMCID: PMC6026053

Lynch C, Zhao J, Huang R, Kanaya N, Bernal L, Hsieh JH, Auerbach SS, Witt KL, Merrick BA, Chen S, Teng CT, Xia M. Identification of Estrogen-Related Receptor αAgonists in the Tox21 Compound Library. Endocrinology. 2018; 159(2):744-753. PubMed [journal] PMID: 29216352, PMCID: PMC5774247

Hsu PY, Wu VS, Kanaya N, Petrossian K, Hsu HK, Nguyen D, Schmolze D, Kai M, Liu CY, Lu H, Chu P, Vito CA, Kruper L, Mortimer J, Chen S. Dual mTOR Kinase Inhibitor MLN0128 Sensitizes HR+/HER2+ Breast Cancer Patient-Derived Xenografts to Trastuzumab or Fulvestrant. Clinical cancer research: an official journal of the American Association for Cancer Research. 2018; 24(2):395-406. PubMed [journal] PMID: 29079660

Liu CY, Wu CY, Petrossian K, Huang TT, Tseng LM, Chen S. Treatment for the endocrine resistant breast cancer: Current options and future perspectives. The Journal of steroid biochemistry and molecular biology. 2017; 172:166-175. PubMed [journal] PMID: 28684381

Kanaya N, Somlo G, Wu J, Frankel P, Kai M, Liu X, Wu SV, Nguyen D, Chan N, Hsieh MY, Kirschenbaum M, Kruper L, Vito C, Badie B, Yim JH, Yuan Y, Hurria A, Peiguo C, Mortimer J, Chen S. Characterization of patient-derived tumor xenografts (PDXs) as models for estrogen receptor positive (ER+HER2- and ER+HER2+) breast cancers. The Journal of steroid biochemistry and molecular biology. 2017; 170:65-74. NIHMSID: NIHMS785187 PubMed [journal] PMID: 27154416, PMCID: PMC5094906

Wang Y, Zhou D, Phung S, Warden C, Rashid R, Chan N, Chen S. SGK3 sustains ERα signaling and drives acquired aromatase inhibitor resistance through maintaining endoplasmic reticulum homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 2017; 114(8):E1500-E1508. PubMed [journal] PMID: 28174265, PMCID: PMC5338386

Cao H, Mu Y, Li X, Wang Y, Chen S, Liu JP. A Systematic Review of Randomized Controlled Trials on Oral Chinese Herbal Medicine for Prostate Cancer. PloS one. 2016; 11(8):e0160253. PubMed [journal] PMID: 27490098, PMCID: PMC4973922

Chan HJ, Petrossian K, Chen S. Structural and functional characterization of aromatase, estrogen receptor, and their genes in endocrine-responsive and -resistant breast cancer cells. The Journal of steroid biochemistry and molecular biology. 2016; 161:73-83. NIHMSID: NIHMS722586 PubMed [journal] PMID: 26277097, PMCID: PMC4752924

Chen S, Hsieh JH, Huang R, Sakamuru S, Hsin LY, Xia M, Shockley KR, Auerbach S, Kanaya N, Lu H, Svoboda D, Witt KL, Merrick BA, Teng CT, Tice RR. Cell-Based High-Throughput Screening for Aromatase Inhibitors in the Tox21 10K Library. Toxicological sciences: an official journal of the Society of Toxicology. 2015; 147(2):446-57. PubMed [journal] PMID: 26141389, PMCID: PMC4592355

Chan HJ, Li H, Liu Z, Yuan YC, Mortimer J, Chen S. SERPINA1 is a direct estrogen receptor target gene and a predictor of survival in breast cancer patients. Oncotarget. 2015; 6(28):25815-27. PubMed [journal] PMID: 26158350, PMCID: PMC4694868

Wu VS, Kanaya N, Lo C, Mortimer J, Chen S. From bench to bedside: What do we know about hormone receptor-positive and human epidermal growth factor receptor 2-positive breast cancer? The Journal of steroid biochemistry and molecular biology. 2015; 153:45-53. NIHMSID: NIHMS692645 PubMed [journal] PMID: 25998416, PMCID: PMC4568143

Twardowski P, Kanaya N, Frankel P, Synold T, Ruel C, Pal SK, Junqueira M, Prajapati M, Moore T, Tryon P, Chen S. A phase I trial of mushroom powder in patients with biochemically recurrent prostate cancer: Roles of cytokines and myeloid-derived suppressor cells for Agaricus bisporus-induced prostate-specific antigen responses. Cancer. 2015; 121(17):2942-50. NIHMSID: NIHMS869874 PubMed [journal] PMID: 25989179, PMCID: PMC5685188

Chen Z, Yuan YC, Wang Y, Liu Z, Chan HJ, Chen S. Down-regulation of programmed cell death 4 (PDCD4) is associated with aromatase inhibitor resistance and a poor prognosis in estrogen receptor-positive breast cancer. Breast cancer research and treatment. 2015; 152(1):29-39. NIHMSID: NIHMS696192 PubMed [journal] PMID: 26026468, PMCID: PMC4470793

Kai M, Kanaya N, Wu SV, Mendez C, Nguyen D, Luu T, Chen S. Targeting breast cancer stem cells in triple-negative breast cancer using a combination of LBH589 and salinomycin. Breast cancer research and treatment. 2015; 151(2):281-94. NIHMSID: NIHMS723944 PubMed [journal] PMID: 25904215, PMCID: PMC4587767

Kanaya N, Nguyen DM, Lu H, Wang YZ, Hsin LY, Petreas M, Nelson D, Guo W, Reynolds P, Synold T, Chen S. AroER tri-screen™ is a novel functional assay to estimate both estrogenic and estrogen precursor activity of chemicals or biological specimens. Breast cancer research and treatment. 2015; 151(2):335-45. NIHMSID: NIHMS723943 PubMed [journal] PMID: 25962693, PMCID: PMC4591046

Chen Z, Wang Y, Warden C, Chen S. Cross-talk between ER and HER2 regulates c-MYC-mediated glutamine metabolism in aromatase inhibitor resistant breast cancer cells. The Journal of steroid biochemistry and molecular biology. 2015; 149:118-27. NIHMSID: NIHMS663846 PubMed [journal] PMID: 25683269, PMCID: PMC4380584

Chen Z, Wang O, Nie M, Elison K, Zhou D, Li M, Jiang Y, Xia W, Meng X, Chen S, Xing X. Aromatase deficiency in a Chinese adult man caused by novel compound heterozygous CYP19A1 mutations: effects of estrogen replacement therapy on the bone, lipid, liver and glucose metabolism. Molecular and cellular endocrinology. 2015; 399:32-42. NIHMSID: NIHMS636635 PubMed [journal] PMID: 25301327, PMCID: PMC4457386

Li F, Wong TY, Lin SM, Chow S, Cheung WH, Chan FL, Chen S, Leung LK. Coadministrating luteolin minimizes the side effects of the aromatase inhibitor letrozole. The Journal of pharmacology and experimental therapeutics. 2014; 351(2):270-7. PubMed [journal] PMID: 25138022

Wong TY, Li F, Lin SM, Chan FL, Chen S, Leung LK. Celecoxib increases miR-222 while deterring aromatase-expressing breast tumor growth in mice. BMC cancer. 2014; 14:426. PubMed [journal] PMID: 24923427, PMCID: PMC4070644

Wang Y, Wong TY, Chan FL, Chen S, Leung LK. Assessing the effect of food mycotoxins on aromatase by using a cell-based system. Toxicology in vitro: an international journal published in association with BIBRA. 2014; 28(4):640-6. PubMed [journal] PMID: 24512813

Wang Y, Zhou D, Chen S. SGK3 is an androgen-inducible kinase promoting prostate cancer cell proliferation through activation of p70 S6 kinase and up-regulation of cyclin D1. Molecular endocrinology (Baltimore, Md.). 2014; 28(6):935-48. PubMed [journal] PMID: 24739041, PMCID: PMC4042072

Chen S, Zhou D, Hsin LY, Kanaya N, Wong C, Yip R, Sakamuru S, Xia M, Yuan YC, Witt K, Teng C. AroER tri-screen is a biologically relevant assay for endocrine disrupting chemicals modulating the activity of aromatase and/or the estrogen receptor. Toxicological sciences: an official journal of the Society of Toxicology. 2014; 139(1):198-209. PubMed [journal] PMID: 24496634, PMCID: PMC4038786

Wang Y, Xu W, Zhou D, Neckers L, Chen S. Coordinated regulation of serum- and glucocorticoid-inducible kinase 3 by a C-terminal hydrophobic motif and Hsp90-Cdc37 chaperone complex. The Journal of biological chemistry. 2014; 289(8):4815-26. PubMed [journal] PMID: 24379398, PMCID: PMC3931044

Kanaya N, Adams L, Takasaki A, Chen S. Whole blueberry powder inhibits metastasis of triple negative breast cancer in a xenograft mouse model through modulation of inflammatory cytokines. Nutrition and cancer. 2014; 66(2):242-8. PubMed [journal] PMID: 24364759

Kanaya N, Vonderfecht S, Chen S. Androgen (dihydrotestosterone)-mediated regulation of food intake and obesity in female mice. The Journal of steroid biochemistry and molecular biology. 2013; 138:100-6. NIHMSID: NIHMS604184 PubMed [journal] PMID: 23665441, PMCID: PMC4130703

Warden CD, Kanaya N, Chen S, Yuan YC. BD-Func: a streamlined algorithm for predicting activation and inhibition of pathways. PeerJ. 2013; 1:e159. PubMed [journal] PMID: 24058887, PMCID: PMC3775632

For my complete list of published works, see my bibliography:

In The News
An Expert's Voice

Chen Receives $3.3M Grant
for Prostate Mushroom Study


Fighting cancer one cell at a time


Superfoods Researcher Receives $3.3M Grant for Mushroom Study