An NCI-designated Comprehensive Cancer Center
Mark LaBarge Bio Image

Mark LaBarge, Ph.D.

Professor, Department of Population Sciences
Research Focus
  • Breast cancer
  • Aging and breast cancer
  • Microenvironment
  • Human mammary epithelila
  • Stem cell biology
  • Cancer susceptibility
  • Early events in cancer
  • Biomarkers of early detection and prevention

Dr. LaBarge received a B.S. in Genetics from University of California, Davis, and a Ph.D. in Molecular Pharmacology from Stanford University. 

He became passionate about the biology of breast cancer during his postdoctoral training at the Lawrence Berkeley National Laboratory, with his mentor Mina Bissell, Ph.D., where he was an American Cancer Society Fellow, and where he built novel high throughput cell-based systems for studying human mammary stem cell fate decisions in the contexts of combinatorial microenvironments. 

In 2009 he won a Transition to Independence Award from the National Institute on Aging and joined the LBNL faculty.  In 2015 he was awarded the Era of Hope Scholar Award from the Congressionally Directed Medical Research Program to support his team's efforts to translate their laboratory findings into prevention-focused breast cancer therapeutics, which is a major focus of his current research.

Locations

City of Hope Comprehensive Cancer Center, 1500 East Duarte Road

Duarte, CA 91010

  • LaBarge MA, Nelson CM, Villadsen R, Fridriksdottir A, Ruth JR, Stampfer MM, Petersen OW, and Bissell MJ. Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. (2009) Integrative Biology. January 1(1):70-79. PMCID: PMC2933184
  • Chanson L, Brownfield D, Garbe, JC, Kuhn I, Stampfer MR, Bissell MJ, and LaBarge MA#. Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells. PNAS (2011), 108(8)3264-9. PMCID: PMC3044373
  • Garbe JC, Pepin F, Pelissier FA, Fridriksdottir A, Sputova K, Guo DE, Villadsen R, Park M, Petersen OW, Barowsky A, Stampfer MR, and LaBarge MA. Accumulation of multipotent progenitors with a basal differentiation bias during aging of human mammary epithelia. Cancer Research (2012). Jul 15;72(14):3687-3701. Epub 2012 May 2. PMCID: PMC3399034
  • Pelissier FA, Garbe JC, Ananthanarayanan B, Miyano M, Lin CH, Jokela T, Kumar S, Stampfer R, Lorens JB, and LaBarge MA. Age-related dysfunction of mechano-transduction impairs differentiation of human mammary epithelial progenitors. Cell Reports (2014), June 26 PMCID: PMC4122253
  • Breast Cancer beyond the Age of Mutation. LaBarge MA, Mora-Blanco EL, Samson S, Miyano M., Gerontology. 2016; 62(4):434-42. NIHMSID: NIHMS734389
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