An NCI-designated Comprehensive Cancer Center

Jeffrey Y.C. Wong, M.D.

Radiation Oncologist
Clinical Expertise
  • Genitourinary Cancers
  • Hematologic Malignancies
  • Image-Guided Intensity Modulated Radiation Therapy (IG-IMRT) / TomoTherapy
  • Total Body Irradiation
  • Radioimmunotherapy
Research Focus
  • Radiation Treatment for Hematologic, Genitourinary and Gastrointestinal Cancers
  • Focused Ultrasound
Appointments
Chair and Professor, Department of Radiation Oncology

Clinical Teams

  • Acute Myeloid Leukemia
  • Gastrointestinal Cancers
  • Genitourinary Cancers
  • Hematology & Hematopoietic Cell Transplantation
We want to make a difference not only today....but also for tomorrow, for future generations.

For more than 25 years, Jeffrey Y.C. Wong, M.D., has guided City of Hope’s radiation oncology department through unprecedented growth. The program now boasts the latest technologies, including image-guided intensity-modulated radiation therapy, image-guided radiation therapy, TomoTherapy, CT simulation, functional tumor imaging, radioimmunotherapy and advanced brachytherapy technologies.

Wong, a graduate of Johns Hopkins University, is also co-director of City of Hope’s cutting-edge theranostics program, which enables clinicians to find and treat tumor cells at the same time.

His primary areas of research include the development of novel strategies and agents for image-guided and biologically targeted radiation therapy for patients with locoregional and systemic disease.

Wong’s team pioneered and developed the use of a targeted form of bone marrow irradiation, treating the first case in 2005, in a collaborative effort between the Department of Radiation Oncology and the Bone Marrow Transplant Program. Since 2002, he has helped lead a team to develop and clinically evaluate a new method of delivering a more targeted form of total body irradiation (TBI) that uses large field image-guided intensity-modulated radiotherapy in patients undergoing hematopoetic cell transplantations for a variety of advanced hematologic malignancies. His team was the first in the world to use this method, total marrow irradiation (TMI) or total marrow and lymphoid irradiation (TMLI), on patients. This approach provides the treating oncologist much more control of dose delivery to target areas and dose avoidance of normal organs.

He has been involved with the development and implementation of TMLI protocols at City of Hope, and has also helped to lead the effort to use Tomotherapy and VMAT to deliver TBI. A TMI database has been developed to capture data for patients receiving IMRT-based TBI, TMI and TMLI worldwide. His team has collaborated with centers in Asia and Europe to initiate TMI and TMLI programs.

As co-director of the theranostics program, Wong works on the development and use of targeted radiopharmaceuticals for therapy, imaging and image-guided radiotherapy, focusing on the development and clinical evaluation of radiolabeled antibodies. He has been the principal investigator of approximately 20, and co-PI on an additional three, radioimmunotherapy clinical trials.

Locations

City of Hope Comprehensive Cancer Center, 1500 East Duarte Road

Duarte, CA 91010

Most recent publications below, additional ones are listed here on PubMed.

Editors: Wong, Jeffrey, Hui, Susanta K. (Eds.)
This book, written by a team of international experts, concisely reviews the rationale and clinical application of image-guided total marrow irradiation, a rapidly emerging area in radiation oncology and hematopoietic cell transplantation. The aim is to provide the practicing radiation oncologist, hematologist, medical physicist, and bone marrow transplant researcher with a fundamental understanding of key aspects and an appreciation of the increasing significance of total marrow irradiation as conditioning for bone marrow transplantation. Detailed attention is paid to the impacts of recent advances in radiation therapy technology, functional PET and MRI, and understanding of the response of bone marrow to radiation.  Full consideration is also given to the ways in which technological advances in image-guided radiation therapy have created new opportunities to treat bone marrow transplant patients with limited transplant options due to advanced disease, age, or co-morbidities. Further topics covered include the ways in which cancer stem cells and the marrow microenvironment influence response to radiation therapy and the implementation of new-generation predictive radiobiologic factors in the clinic.
 

Wong, Jeffrey, Schutheiss, Tim, Radany, Eric (Eds.) Advances in Radiation Oncology. Springer International Publishing, 2017.

Hall, MD, Schultheiss, TE, Smith, DD, Fakih, MG, Kim, J, Wong, JYC, and Chen, Y. Impact of total lymph node count on staging and survival after neoadjuvant chemoradiation therapy for rectal cancer. Ann Surg Oncol, 2015, in press.

Hall MD, Schultheiss TE, Smith DD, Tseng B P, Wong JYC. The impact of increasing dose on overall survival in prostate cancer. Radiation Oncology, 10, 2015

Hall, MD, Schultheiss, TE, Smith. DD, Nguyen, KH, Wong, JYC:  Dose response for radiation cataractogenesis: a meta-regression of hematopoietic stem cell transplantation regimens. Int J Radiat Oncol Biol Phys., 91(1):22-29, 2015.

Hall, MD, Chen, Y-J, Schultheiss, TE, Pezner, RD, Stein, AS, Wong, JYC:  Treatment outcomes for patients with chloroma receiving radiation therapy. J Med Imaging Radiat Oncol., 58:523-527, 2014.

Kim, J.H., Stein, A., Tsai, N.C., Schultheiss, T.E., Palmer, J., Liu, A., Rosenthal, J., Forman, S.J., Wong, J.Y.C.:  Extramedullary relapse following total marrow and lymphoid irradiation in patients undergoing allogenic hematopoietic cell transplant.  Int. J. Radiat. Oncol. Biol. Phys., 89(1):75-81, 2014.

Chen, X., Radany, E.H., Wong, P., Ma, S., Wu, K., Wang, B., Wong, J.Y.C.:  Suberoylanilide hydroxamic acid induces hypersensitivity to radiation therapy in acute myelogenous leukemia cells expressing constitutively active FLT3 mutants.  PLOS One, 8(12):1-14, 2013.

Wong, J.Y.C., Forman, S., Somlo, G., Rosenthal, J., Liu, A., Schultheiss, T., Radany, E., Palmer, J., Stein, A.:  Dose escalation of total marrow irradiation with concurrent chemotherapy in patients with advanced acute leukemia undergoing allogeneic hematopoietic cell transplantation.  Int. J. Radiat. Oncol. Biol. Phys., 85(1):148-156, 2013.

VanderWalde, A., Ye, W., Frankel, P., Asuncion, D., Leong, L., Luu, T., Morgan, R., Twardowski, P., Koczywas, M., Pezner, R., Paz, I.B., Margolin, K., Wong, J., Doroshow, J.H., Forman, S., Shibata, S., Somlo, G.:  Long-term survival after high-dose chemotherapy followed by peripheral stem cell rescue for high-risk, locally advanced/inflammatory, and metastatic breast cancer.  Biol Blood Marrow Transplant, 18:1273-1280, 2012.

Chen, X., Wong, P., Radany, E.H., Stark, J.M., Laulier, C., Wong, J.Y.C.:  Suberoylanilide hydroxamic acid as a radiosensitizer through a modulation of RAD51 protein and homology-directed repair in multiple myeloma.   Molecular Cancer Research, 10(8):1052-64, 2012.

Han, C., Schultheiss, T.E., Wong, J.Y.C.:  Dosimetric study of volumetric modulated arc therapy fields for total marrow irradiation.  Radiotherapy Oncology, 102: 315-320, 2012.

Han, C., Schiffner, D.C., Schultheiss, T.E., Chen, Y-J, Liu, A., Wong, J.Y.C.:  Residual setup errors and dose variations with less-than-daily image guided patient setup in external beam radiotherapy for esophageal cancer.  Radiotherapy and Oncology, 102: 309-314, 2012.

Chen, Y-J., Suh, S., Nelson, R.A., Liu, A., Pezner, R.D., Wong, J.Y.C.:  Setup variations in radiotherapy of anal cancer:  Advantages of target volume reduction using image-guided radiation treatment.  Int. J. Radiat. Oncol. Biol. Phys., 84(1):289-295, 2012.

Sampath, S., Hitchcock, Y.J., Shrieve, D.C., Randall, L., Schultheiss, T.E., Wong, J.:  Pre-operative versus post-operative radiotherapy in soft-tissue sarcoma:  Multi-institutional analysis of 821 patients.  Int. J. Radiat. Oncol. Biol. Phys., 81(2):498-511, 2011.

Stein, A.S., O’Donnell, M.R., Synold, T.W., Dagis, A.C., Tsirunyan, A., Nademanee, A.P., Parker, P.M., Pullarkat, V.A., Snyder, D.S., Spielberger, R.T., Wong, J.Y.C., Alvarnas, J.C., Thomas, S.H., Forman, S.J.:  Phase-2 trial of an intensified conditioning regimen for allogeneic hematopoietic cell transplant for poor-risk lymphoma.  Bone Marrow Transplantation, 46:1256-1262, 2011.

Henkin, R.E., Del Rowe, J.D., Grigsby, P.W., Hartford, A.C., Jadvar, H., Macklis, R.M., Parker, J.A., Wong, J.Y.C., Rosenthal, S.A.:  ACR-ASTRO practice guideline for the performance of therapy with unsealed radiopharmaceutical sources.  Clinical Nuclear Medicine, 36(8):e72-e80, 2011.

Chen, X., Wong, J.Y.C., Wong, P., Radany, E.H.:  Low-dose valproic acid enhances radiosensitivity of prostate cancer through acetylated p53-dependent modulation of mitochondrial membrane potential and apoptosis.  Molecular Cancer Research, 9:448-461, 2011.

Rosenthal, J., Wong, J., Stein, A., Qian, D., Hitt, D., Hossameldin, N., Dagis, A., Thomas, S.H., Forman, S:  Phase I/II trial of total marrow and lymph node irradiation to augment reduced intensity transplant for advanced hematological malignancies.  Blood, 117(1): 309-315, 2011.

Somlo, G., Spielberger, R., Frankel, P., Karanes, C., Krishnan, A., Parker, P., Popplewell, L., Sahebi, F., Kogut, N., Snyder, D., Liu, A., Schultheiss, T., Forman, S., Wong, J.Y.C.:  Total Marrow Irradiation:  A new ablative regimen as part of tandem autologous stem cell transplantation for patients with multiple myeloma.  Clinical Cancer Research, 17: 174-182, 2011.

Sampath, S., Hitchcock, Y.J., Shrieve, D.C., Lor Randall, R., Schultheiss, T.E., Wong, J.:  Radiotherapy and extent of surgical resection in retroperitoneal soft-tissue sarcoma:  Multi-institutional analysis of 292 patients.  J Surg Oncol., 101:345-350, 2010.

Sampath S., Schultheiss, T.E., Ryu, J.K., Wong, J.Y.C.:  The role of adjuvant radiation in uterine sarcomas.  Int. J. Radiat. Oncol. Biol. Phys.,76: 728-734, 2010.

Zhuang, A.H., Liu, A., Schultheiss, T.E., Wong, J.Y.C.:  Dosimetric study and verification of total body irradiation using helical tomotherapy and its comparison to extended SSD technique.  Medical Dosimetry, 35(4): 243-249, 2010.

In The News