Qiong (Annabel) Wang, Ph.D.
- Assistant Professor, Department of Molecular & Cellular Endocrinology
626-218-6419Qiong (Annabel) Wang, Ph.D.
Research Focus
:
- Pathogenesis and treatment of obesity, type 2 diabetes and related metabolic syndromes.
Qiong Wang, Ph.D., joined the Diabetes & Metabolism Research Institute at City of Hope as an assistant professor in the Department of Molecular and Cellular Endocrinology. She comes to City of Hope after her postdoctoral training in Dr. Philipp Scherer’s laboratory at the Touchstone Diabetes Center at The University of Texas Southwestern Medical Center, where she studied adipose tissue physiology.
During her postdoctoral training, Dr. Wang focused on using in vivo models to track adipogenesis, the process of cell differentiation by which preadipocytes become adipocytes, during adipose tissue development and remodeling. She further studied the requirement of key adipogenic transcription factors C/EBPα and PPARγ at various stages of adipogenesis in vivo. Her study showed that different fat depots undergo adipogenesis in distinct time frames both during development and through adulthood. She also unraveled a surprising diversity of transcriptional signals required at various stages of adipogenesis, opening up new possibilities for the selective stage- and location-specific interventions of adipogenesis.
Dr. Wang completed her Ph.D. training in Dr. Yong Liu laboratory at the Shanghai Institutes for Biological Sciences, the Graduate School of Chinese Academy of Sciences. Her graduate study focused on identifying novel targets in the liver for the treatment of obesity and insulin resistance.
Degrees
- 2003-2009, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, CHINA
- 1999-2003 Xinjiang University, Xinjiang, CHINA
Fellowship
- 2009-2015, Touchstone Diabetes Center, UT Southwestern Medical Center, Dallas, TX
The main interest of the Wang laboratory is to better understand the molecular mechanisms that regulate the dynamics of adipogenesis in different fat depots on various occasions. The research efforts are devoted to the pathogenesis and treatment of obesity, type 2 diabetes and related metabolic syndromes.
The Wang laboratory is currently working on two projects: 1) the molecular mechanisms that regulate the dramatic adipose tissue remodeling in the mammary gland, and how dysregulation of this remodeling contributes to whole body metabolic disorders and breast cancer, and 2) brown adipocyte heterogeneity, and how this heterogeneity remodels the energy-burning capacity of brown adipose tissue.
The Wang laboratory is currently working on two projects: 1) the molecular mechanisms that regulate the dramatic adipose tissue remodeling in the mammary gland, and how dysregulation of this remodeling contributes to whole body metabolic disorders and breast cancer, and 2) brown adipocyte heterogeneity, and how this heterogeneity remodels the energy-burning capacity of brown adipose tissue.
Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation. Wang QA, Tao C, Jiang L, Shao M, Ye R, Zhu Y, Gordillo R, Ali A, Lian Y, Holland WL, Gupta RK, Scherer PE. Nature Cell Biology. 2015; 17(9):1099-111. NIHMSID: NIHMS704891
Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Wang QA, Tao C, Gupta RK, Scherer PE. Nature Medicine. 2013; 19(10):1338-44. NIHMSID: NIHMS586873
Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid composition in mice. Wang Q, Li S, Jiang L, Zhou Y, Li Z, Shao M, Li W, Liu Y. Journal of Lipid Research. 2010; 51(9):2516-26.
Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W, Liu Y. Hepatology (Baltimore, Md.). 2009; 49(4):1166-75.
Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid composition in mice. Wang Q, Li S, Jiang L, Zhou Y, Li Z, Shao M, Li W, Liu Y. Journal of Lipid Research. 2010; 51(9):2516-26.
Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W, Liu Y. Hepatology (Baltimore, Md.). 2009; 49(4):1166-75.
- 2015, Keystone Symposia Scholarship, Keystone Symposia on Molecular and Cellular Biology
- 2015, Young Investigator Travel Grant Award, American Diabetes Association
- 2011-2015, American Diabetes Association Mentor-Based Postdoctoral Fellowship Award
- 2009, Chinese Academy of Sciences Dean Award, the Graduate School of Chinese Academy of Sciences
- 2008, Excellent Yong Physiologist Reward, International Union of Physiological Sciences