Adam J. de Smith, Ph.D. is an Associate Professor in the Department of Pediatrics and Department of Population Sciences at the Beckman Research Institute of the City of Hope®, and a member of the City of Hope Comprehensive Cancer Center. He is a Scholar of Blood Cancer United (formerly Leukemia & Lymphoma Society).
Dr. de Smith’s research focuses on identifying the causes of acute lymphoblastic leukemia (ALL), the most common childhood cancer. He is particularly interested in understanding the increased risk of ALL in children of Hispanic/Latino ethnicity, and in studying somatic mutational signatures to examine potential causative agents (mutational epidemiology). He also initiated the International Study of Down Syndrome Acute Leukemia (IS-DSAL), a multi-institutional collaboration investigating the role of genetics and epigenetics in the increased risk of leukemia in children with Down syndrome.
Dr. de Smith received a Ph.D. degree in Human Genetics from Imperial College London and postdoctoral training at the University of California San Francisco, under the mentorship of Dr. Joseph Wiemels. Dr. de Smith is a member of the Children’s Oncology Group (COG) Epidemiology Committee, the Childhood Cancer and Leukemia International Consortium (CLIC), and a collaborator with the California Childhood Leukemia Study (CCLS).
