Lei Dong, Ph.D.

[email protected]
626-218-5628
Lei Dong, Ph.D.
Staff Scientist, Department of Systems Biology
Research Area
  • Developing a Manually Extracted Database of Experimentally Supported Database of RNA Deregulation in Various Cancers
  • Systematic Analysis of Epigenetic Regulation of RNA Expression in Gastric Cancer
  • Identifying SNP INDEL SV and CNV in Cancer Cells by Using Single Cell Sequence
  • Analyzing the Results of ChIP and Next-generation Sequencing, Developing Innovative Algorithms for High-throughput Data
Research Teams
Systems Biology

  • 2014, Ph.D., Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, China

  • 2010, M.S., Life Sciences, Xiamen University, China

  • 2007, B.S., Biotechnology, Shandong University, China

Location

Education & Experience

Degrees

  • 2014, Ph.D., Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, China

  • 2010, M.S., Life Sciences, Xiamen University, China

  • 2007, B.S., Biotechnology, Shandong University, China

Professional Experience

  • 2018-present, Staff Scientist, Department of Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA

  • 2017 – 2018, Postdoctoral Fellow, Department of Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA

  • 2015 - 2017, Postdoctoral Fellow, Department of Cancer Biology, University of Cincinnati, Cincinnati, OH

  • 2014 - 2015, Postdoctoral Fellow, School of Computing Science, Computational Biology Lab, Simon Fraser University, Canada & School of Informatics and Computing, Indiana University Bloomington, IN

Awards & Memberships

Awards

  • 2011-2013, Scholarship awarded from Peking Union Medical College

Publications

  • Su R*, Dong L*, Li C*, Nachtergaele S*, Wunderlich M, Wang Y, Weng X, Hu C, Yu M, Strong J, Dai Q, Zou D, Qing Y, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki AT, Plas D, Bradner JE, Wei M, Marcucci G, Jiang X, Mulloy J, Jin J, He C, Chen J. R-2HG exhibits anti-tumor activity by targeting FTO/MYC signaling. Cell, 2018 Jan 11;172(1-2):90-105.e23. (*co-first author)
  • Weng H*, Huang H*, Wu H*, Qin X*, Zhao BS*, Dong L*, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich M, Zhang B, Dore LC, Su R, Deng X, Ferchen K, Li, Sun, Lu, Jiang, Marcucci, Mulloy, Yang, Qian Z, Wei M, He C, Chen J. METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification. Cell Stem Cell. 2018 Feb 1;22(2):191-205.e9. (*co-first author)
  • Su R*, Dong L*, Zou D, Zhao H, Yi R, Li F, Yi P, Li L, Zhu Y, Ma Y, Wang F, Yu J. microRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia. Oncogene. 2016 Apr 18. doi: 10.1038/onc.2016.127. (*co-first author)
  • Dong L, Luo M, Wang F, Zhang J, Li T, Yu J. TUMIR: an experimentally supported database of microRNA deregulation in various cancers. J Clin Bioinforma. 2013 Apr 17;3(1):7.
  • Huang Y*, Su R*, Dong Z*, Dong L*, Xu H, Ni Zijie TN, Zhang S, Li Q, Zhang T, Li C, Zhu Z, Lian F, Gao Z, Zhong D, Zhou H, Zhang N, Gan J, Chen J, Yang C-G. Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia. Cancer Cell (under review) (*co-first author)
  • Li C*, Dong L*, Su R, Bi Y, Qing Y, Deng X, Zhou Y, Hu C, Yu M, Huang H, Jiang X, Li X, He X, Zou D, Shen C, Skibbe J, Ferchen K, Qin X, Weng H, Huang H, Song C, Jin1 J, Chen C. Homoharringtonine exhibits potent anti-tumor effect and affects DNA epigenome in AML by targeting SP1/TET1/5hmC/FLT3/MYC. Oncogene (under review) (*co-first author)
  • Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu Y-C, Hüttelmaier S, Skibbe JR, Su R, Deng X, Dong L, Sun M, Nachtergaele CLS, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X, Wei M, Qu L, Guan J-L, He C, Yang J, Chen J. Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol. 2018 Mar;20(3):285-295
  • Jiang X, Hu C, Ferchen K, Nie J, Cui X, Chen C-H, Cheng L, Zuo Z, Seibel W, He C, Tang Y, Skibbe JR, Wunderlich M, C. Reinhold WC, Dong L, Shen C, Arnovitz S, Ulrich B, Lu J, Weng H, Su R, Huang H, Wang Y, Li C, Qin X, Mulloy JC, Zheng Y, Diao J, Jin J, Li C, P. Liu PP, He C, Chen Y, Chen J. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099.
  • Li Z*, Weng H*, Su R*, Weng X*, Zuo Z*, Li C, Huang H, Nachtergaele S, Dong L, Hu C, Qin X, Tang L, Wang Y, Hong G-M, Huang H, Wang X, Chen P, Gurbuxani S, Arnovitz S, Li Y, Li S, Strong J, Neilly MB, Larson RA, Le Beau MM, Jiang X, Zhang P, Jin J, He C, Chen J. FTO plays an oncogenic role in acute myeloid leukemia as a N6-methyladenosine RNA demethylase. Cancer Cell, 2017 Jan 9;31(1):127-141.
  • Wang F, Song W, Zhao H, Ma Y, Li Y,  Zhai D, Pi J, Si Y, Xu J, Dong L, Su R, Zhang M, Zhu Y, Ren X, Miao F, Liu W, Li F, Zhang J, He A, Shan G, Hui J, Wang L, Yu J. The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis. Cell Research. 2017 Mar;27(3):416-439
  • Wang Y, Skibbe JR, Hu C, Dong L, Ferchen K, Su R, Li C, Huang H, Weng H, Huang H, Xin X, Jin J, Chen J, Jiang X.  ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia. Sci Rep.  2017 May12;7(1):1853.
  • Yin H*, Song P*, Su R*, Yang G, Dong L, Luo M, Wang B, Gong B, Liu C, Song W, Wang F, Ma Y, Zhang J, Wang W, Yu J. DNA Methylation mediated down-regulating of microRNA-33b and its role in gastric cancer. Sci Rep. 2016 Jan 5;6:18824.
  • Chen M-T, Dong L, Zhang X-H, Yin X-L, Ning H-M, Shen C, Su R, Li F, Song L, Ma Y-N, Wang F, Zhao H-L, Yu J, Zhang J-W. ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK6. Sci Rep. 2015 Nov 6;5:16229.
  • He X, Li J, Guo W, Liu W, Yu J, Song W, Dong L, Wang F, Yu S, Zheng Y, Chen S, Kong Y, Liu C. Targeting the microRNA-21/AP1 axis by 5-fluorouracil and pirarubicin in human hepatocellular carcinoma. Oncotarget. 2015 Feb 10;6(4):2302-14.
  • Ma Y, Yao N, Liu G, Dong L, Liu Y, Zhang M, Wang F, Wang B, Wei X, Dong H, Wang L, Ji S, Zhang J, Wang Y, Huang Y, Yu J. Functional screen reveals essential roles of miR‐27a/24 in differentiation of embryonic stem cells. EMBO J. 2015 Feb 3;34(3):361-78.
  • Wang Y, Liu C, Luo M, Zhang Z, Gong J, Li J, You L, Dong L, Su R, Lin H, Ma Y, Wang F, Wang Y, Chen J,  Zhang J, Jia H, Kong Y, Yu J. Chemotherapy-Induced miRNA-29c/Catenin-δ Signaling Suppresses Metastasis in Gastric Cancer. Cancer Res. 2015 Apr 1;75(7): 1332-44
  • Li Z, Lei H, Luo M, Wang Y, Dong L, Ma Y, Liu C, Song W, Wang F, Zhang J, Shen J, Yu J. DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer. Gastric Cancer. 2015 Jan;18(1):43-54. 
  • Li Y, Bai H, Zhang Z, Li W, Dong L, Wei X, Ma Y, Zhang J, Yu J, Guotao Sun2 G, Fang Wang F. The up-regulation of miR-199b-5p in erythroid differentiation is associated with GATA-1 and NF-E2. Mol Cells. 2014 Mar;37(3):213-9. 
  • Gong J, Li J, Wang Y, Liu C, Jia H, Jiang C, Wang Y, Luo M, Zhao H, Dong L, Song W, Wang F, Wang W, Zhang J, Yu J. Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer. Carcinogenesis. 2014 Feb;35(2):497-506.
  • Wang F, Zhu Y, Guo L, Dong L, Liu H, Yin H, Zhang Z, Li Y, Liu C, Ma Y, Song W, He A, Wang Q, Wang L, Zhang J, Li J, Yu J. A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis. Nucleic Acids Res. 2014 Jan;42(1):442-57.
  • Jia H, Zhang Z, Zou D, Wang B, Yan Y,  Luo M, Dong L, Yin H, Gong B, Li Z, Wang F, Song W,  Liu C, Ma Y, Zhang J, Zhao H, Li J, Yu J. MicroRNA-10a is down-regulated by DNA methylation and functions as a tumor suppressor in gastric cancer cells. PLoS One. 2014 Jan 31;9(1):e88057. 
  • Zhu Y, Wang D, Wang F, Li T, Dong L, Liu H, Ma Y, Jiang F, Yin H, Yan W, Luo M, Tang Z, Zhang G, Wang Q, Zhang J, Zhou J, Yu J. A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis. Nucleic Acids Res. 2013 Apr;41(7):4129-43.
  • Ma Y, Wang B, Jiang F, Wang D, Liu H, Yan Y, Dong H, Wang F, Gong B, Zhu Y, Dong L, Yin H, Zhang Z, Zhao H, Wu Z, Zhang J, Zhou J, Yu J. A feedback loop consisting of microRNA 23a/27a and the β-like globin suppressors KLF3 and SP1 regulates globin gene expression. Mol Cell Biol. 2013 Oct;33(20):3994-4007.
  • Lei H, Zou D, Li Z, Luo M, Dong L, Wang B, Yin H, Ma Y, Liu C, Wang F, Zhang J, Yu2 J, Li Y. MicroRNA-219-2-3p functions as a tumor suppressor in gastric cancer and is regulated by DNA methylation. PLoS One. 2013 Apr 23;8(4):e60369.
  • Li J, Zhu X, Wang X, Sun W, Feng B, Du T, Sun B, Niu F, Wei H, Wu X, Dong L, Li L, Cai X, Wang Y, Liu Y. Targeted genomic sequencing identifies PRRT2 mutations as a cause of paroxysmal kinesigenic choreoathetosis. J Med Genet. 2012 Feb;49(2):76-8.