Xiaohua Xu, Ph.D.

(877) 460-4673
Xiaohua Xu, Ph.D.
Staff Scientist, Cancer Genetics and Epigenetics

Xiaohua Xu, Ph.D., is an staff scientist in the Department of Cancer Genetics and Epigenetics at City of Hope in Los Angeles

Location

Education & Experience

Degrees

  • 2004, Ph.D., Tottori University, Japan
  • 1997, B.S., Fuzhou University, China

Professional Experience

  • 2011 - Present, Staff Scientist, Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope
  • 2011 - 2011, Associate Research Scientist, Department of Therapeutic Radiology, Yale University
  • 2008 - 2010, Postdoctoral research associate, Department of Therapeutic Radiology, Yale University
  • 2005 - 2007, Postdoctoral research fellow, Department of Structural Biology, Stanford University
  • 1997 - 2001, Research assistant, Institute of Biotechnology Fuzhou University, China

Awards & Memberships

Awards

  • 2001 - 2004, Japanese government (Monbusho) scholarship

Publications

  • Li M*., Xu X*., Chang ZW*., Zheng l. et al. RECQ5 facilitates chromatin remodeling via SUMO2-PCNA to prevent transcription-replication conflict. Nat. Commun. 9(1):2706. doi: 10.1038/ s41467-018-05236-y *co-1st author
  • Xu X., Wang JT., Li M., Liu Y. (2016) TIMELESS suppresses the accumulation of aberrant CDC45-MCM2-7-GINS replicative helicase complexes on human chromatin. J. Biol. Chem. 291, 22544-22558
  • Li M., *Pokharel S., *Wang JT., *Xu X., Liu Y. (2015) RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability. Nat. Commun. 6:6720. doi: 10.1038/ncomms7720 *co-2nd author
  • Wang J., Xu X., Alontaga A., Chen y., Liu Y. (2014) Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction. Cell Rep. pii: S2211-1247
  • Hansen JE., Chan G., Liu Y., Hegan DC., Dalal S., Dray E., Kwon Y., Xu Y., Xu X. et al (2012). Targeting cancer with a lupus autoantibody. Sci Transl Med. 4,157ra142
  • Machwe A., Karale R., Xu X., Liu Y., Orren D.K. (2011) The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holiday junctions to functional replication forks. Biochemistry. 50, 6774-6788
  • Li M., Xu X., Liu Y. (2011) The SET2-RPB1 interaction domain of human RECQ5 is important for transcription-associated genome stability. Mol Cell Biol. 31, 2090-2099
  • Xu X*., Rochette PJ*. et al. (2009) MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication. EMBO J. 28, 3005-3014 *co-1st author
  • Aygün O., Xu X., Liu Y., Takahashi H. et al. (2009) Direct inhibition of RNA polymerase II transcription by RECQL5. J. Biol. Chem. 284, 23197-23203
  • Xu X., Liu Y. (2009) Dual DNA unwinding activities of the human Rothmund-T homson Syndrome protein, RECQ4. EMBO J. 28, 568-577
  • Xu X., Wang S. et al. (2007) The periplasmic bacterial molecular chaperone SurA adapts its structure to bind peptides in alternate conformations to assert a sequence preference for aromatic residues. J. Mol. Biol. 373, 367-381
  • Xu X., Azakami H. et al. (2004) P-domain and lectin site are involved in the chaperone function of Saccharomyces cerevisiae calnexin homologue (Cne1p). FEBS Lett. 570, 155-160
  • Xu X., Kanbara K. et al. (2004) Expression and characterization of Saccharomyces cerevisiae Cne1p, a calnexin homologue. J. Biochem (Tokyo). 135, 615-618
  • Xu X., Kashima O. et al. (2004) Structural and functional properties of chicken lysozyme fused serine-rich heptapeptides at C-terminus. Biosci. Biotechnol. Biochem. 68, 1273-1278
  • Begum S., Saito A., Xu X. et al. (2003) Improved functional properties of the ovoinhibitor by conjugating with galactomannan. Biosci. Biotechnol. Biochem. 67, 1897-1902
  • Xu X., Li R. et al. (2002) Quantification of cholesterol in foods using non-aqueous capillary electrophoresis. J Chromatogr. B Biomed. Sci. Appl. 768, 369-373
  • Chen G.R., Xu X. et al. (2001) Fractionation of Corynebacterium pekinense AS 1.299 phage subtypes by anion-exchange chromatography. J. Virol. Methods 95, 11-17
  • Zhang R., Xu X. et al. (2000) An assay for angiotensin-converting enzyme using capillary zone electrophoresis. Anal. Biochem. 280, 286-290