Zhao Wang, Ph.D.

Ph.D. in Cell Biology, Albert Einstein College of Medicine, Bronx, New York
M.S. in Molecular Genetics, Fudan University, Shanghai, China
B.S. in Biochemistry, Fudan University, Shanghai, China
2008-2013, Postdoctoral fellow, Division of Cardiology, Department of Internal Medicine University of Texas Southwestern Medical Center, Dallas, Texas
2021-present, Associate Professor, Department of Diabetes & Cancer Metabolism, Beckman Research Institute of City of Hope, Duarte, California
2021, Associate Professor with tenure, Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas
2015-2021, Assistant Professor, tenure track, Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas
2021, Fellow of American Heart Association (FAHA)
2015, Outstanding Oral Presentation Award, ACRE-CNAHA Federation, Orlando, Florida
2013, Finalist, the Louis N. and Arnold M. Katz Basic Science Research Prize for Young Investigators, American Heart Association, Dallas, Texas
2017-present, Member, International Society for Heart Research
2009-present, Member, American Heart Association
2008-present, Member, American Diabetes Association
- Zhang G, Wang X, Rothermel BA, Lavandero S, Wang ZV. The integrated stress response in ischemic diseases. Cell Death & Differ. In press.
- Zhang G, Wang X, Li C, Li Q, An YA, Luo X, Deng Y, Gillette TG, Scherer PE, Wang ZV. Integrated stress response couples mitochondrial protein translation with oxidative stress control. Circulation 2021; 144(18): 1500-1515.
- Li Q, Li C, Elnwasany A, Sharma G, An YA, Zhang G, Elhelaly WM, Lin J, Gong Y, Chen G, Wang MH, Zhao S, Dai C, Smart CD, Liu J, Luo X, Deng Y, Tan L, Lv SJ, Davidson SM, Locasale JW, Lorenzi PL, Malloy CR, Gillette TG, Vander Heiden MG, Scherer PE, Szweda LI, Fu G, Wang ZV. PKM1 exerts critical roles in cardiac remodeling under pressure overload in the heart. Circulation 2021; 144(9): 712-727.
- Li Q, Taegtmeyer H, Wang ZV. Diverging consequences of hexosamine biosynthesis in cardiovascular disease. J Mol Cell Cardiol. 2021; 153: 104-105.
- Dai C, Li Q, May HI, Li C, Zhang G, Sharma G, Sherry AD, Malloy CR, Khemtong C, Zhang Y, Deng Y, Gillette TG, Xu J, Scadden DT, Wang ZV. Lactate dehydrogenase A governs cardiac hypertrophic growth in response to hemodynamic stress. Cell Rep. 2020; 32: 108087.
- Tran HD, May HI, Li Q, Luo X, Huang J, Zhang G, Niewold E, Wang X, Gillette TG, Deng Y, Wang ZV. Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling. Nat. Commun. 2020; 11(1): 1771.
- Zhang G, Wang X, Gillette TG, Deng Y, Wang ZV. Unfolded protein response as a therapeutic target in cardiovascular disease. Curr Top Med Chem. 2019; 19(21): 1902-1917.
- Wang X, Deng Y, Zhang G, Li C, Ding G, May HI, Tran DH, Jiang DS, Li DL, Wei X, Xu L, Ferdous A, Gillette TG, Scherer PE, Jiang X, Wang ZV. Spliced X-box binding protein 1 stimulates adaptive growth through activation of mTOR. Circulation 2019; 140(7): 566-579.
- Zhang G, Wang X, Bi X, Li C, Deng Y, Al-Hashimi AA, Luo X, Gillette TG, Austin RC, Wang Y, Wang ZV. GRP78 promotes cardiomyocyte growth through activation of GATA4. Hypertension 2019; 72(2): 390-398.
- Wang X, Bi X, Zhang G, Deng Y, Luo X, Xu L, Scherer PE, Ferdous A, Fu G, Gillette TG, Lee AS, Jiang X, Wang ZV. Glucose-regulated protein 78 is essential for cardiac myocyte survival. Cell Death Differ. 2018; 12(12): 2181-2194.
- Bi X, Zhang G, Wang X, Nguyen C, May HI, Li X, Al-Hashimi A, Austin RC, Gillette TG, Fu G, Wang ZV*, Hill JA*. ER chaperone GRP78 protects heart from ischemia/reperfusion injury through Akt activation. Circ Res. 2018; 122(11): 1545-1554. (*, corresponding authors).
- Deng Y, Wang ZV, Gordillo R, Zhu Y, Ali A, Zhang C, Wang X, Shao M, Iyengar P, Gupta R, Horton JD, Hill JA, Scherer PE. Adipocyte Xbp1s overexpression drives uridine production and reduces obesity. Mol Metab. 2018; 11: 1-17.
- Wang X, Xu L, Gillette TG, Jiang X, Wang ZV. The unfolded protein response in ischemic heart disease. J Mol Cell Cardiol. 2018; 117: 19-25.
- Wang Y, Zhang Y, Ding G, May HI, Xu J, Gillette TG, Wang H, Wang ZV. Temporal dynamics of cardiac hypertrophic growth in response to pressure overload. Am J Physiol Heart Circ Physiol. 2017; 313(6): H1119-H1129.
- Deng Y, Wang ZV, Gordillo R, An Y, Zhang C, Liang Q, Yoshino J, Cautivo KM, De Brabander J, Elmquist JK, Horton JD, Hill JA, Klein S, Scherer PE. Identification of an adipo-billiary-uridine axis that regulates energy homeostasis. Science 2017; 355(6330): aaf5375.
- Wang ZV*, Scherer PE*. Adiponectin, the past two decades. J Mol Cell Biol. 2016; 8(2): 93-100. (*, corresponding authors).
- Li DL, Wang ZV, Ding G, Tan W, Luo X, Criollo A, Xie M, Jiang N, May HI, Kyrychenko V, Schneider JW, Gillette TG, Hill JA. Doxorubicin blocks cardiomyocyte autophagic flux by inhibiting lysosome acidification. Circulation 2016; 133(17): 1668-1687.
- Wang ZV, Hill JA. Diabetic Cardiomyopathy: catabolism driving metabolism. Circulation 2015; 131(9): 771-773.
- Wang ZV, Hill JA. Protein quality control and metabolism: bidirectional control in the heart. Cell Metab. 2015; 21(2): 215-226.
- Wang ZV, Li DL, Hill JA. Heart failure and loss of metabolic control. J Cardiovasc Pharmacol. 2014; 63(4): 302-313.