Nadia Carlesso, M.D., Ph.D.

Research Focus :
  • Mechanisms of hematopoietic cell clonal dominance and transformation
  • Role of Notch signaling in the regulation of inflammation
  • Contribution of inflammation to leukemia and bone marrow failure
  • Microenvironment – Leukemia crosstalk
  • In vivo-visualization of normal and malignant bone marrow niches

Nadia Carlesso MD, PhD, joined the Beckman Research Institute at City of Hope as Professor in the Department of Hematology & Hematopoietic Cell Transplantation and as Associate Director of Basic Research at the Gehr Family Center for Leukemia Research.

Dr. Carlesso and her team will lead efforts to identify novel therapeutic approaches targeting simultaneously the leukemia cells and the leukemic microenvironment, in particular in relapse and refractory disease, and strategies to improve hematopoietic cell engraftment following transplant.

Dr. Carlesso received her MD from the University of Torino (Italy) and her PhD from the University of Genova (Italy). She performed her PhD work at the Dana-Farber Cancer Institute and received the postdoctoral training at the Massachusetts General Hospital, Harvard Medical School.

Dr. Carlesso has been continuously funded by the NIH since 2001. Her work has been supported by NHLBI and NIDDK and by several external grants including the MPN/Leukemia Lymphoma Foundation. She serves on the editorial boards of the Journal of Experimental Hematology and of Trends in Cancer, she is a member of peer review panels for NIH, the Department of Defense and the NY State Stem Cell Science.

  • 2016-Present, Professor, Department of Hematology & Hematopoietic Cell Transplantation, Beckman Research Institute of City of Hope
  • 2016-Present, Associate Director of Basic Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of the City of Hope
  • 2016, Professor of Pediatrics and Medical & Molecular Genetics, University School of Medicine, Indiana University
  • 2010-2015, Associate Professor of Pediatrics and Medical & Molecular Genetics, University School of Medicine, Indiana University
  • 2010-2016, Co-Director, Core Center of Excellence in Hematology (CCEH) Intravital Imaging Core, University School of Medicine, Indiana University
  • 2008-2016, Director, Medical Student Research Program in Academic Medicine, University School of Medicine, Indiana University
  • 2007-2009, Assistant Professor of Pediatrics and Medical & Molecular Genetics, University School of Medicine, Indiana University
  • 2002-2006, Assistant Professor of Medicine, Massachusetts General Hospital, Harvard Medical School
  • 1997-2002, Instructor of Medicine, Massachusetts General Hospital, Harvard Medical School
  • 1995-1997, Postdoctoral Fellow, Massachusetts General Hospital, Harvard Medical School

Degrees

  • 1995 University of Genoa School of Medicine, Italy, Ph.D.
  • 1989 University of Turin School of Medicine, Italy, M.D.

Fellowship

  • 1995-1997, Postdoctoral Fellow, Division of Experimental Hematology, Massachusetts General Hospital, Harvard Medical School. David Scadden-Mentor
  • 1990-1992, Clinical Fellow, Hematology/Oncology, Department of Medicine and Experimental Oncology, Molinette Hospital, University of Turin, Turin, Italy, M.D.

Residency

  • 1989-1990, Resident in Hematology, Division of Hematology, Department of Medicine and Experimental Oncology, Molinette Hospital, University of Turin, Turin, Italy, M.D.

Our laboratory studies the molecular mechanisms driving normal stem cell differentiation and malignant transformation in the hematopoietic system. More specifically we are investigating how the interactions between the bone marrow microenvironment and the hematopoietic stem and progenitor cells shape their cell fate decisions. We are interested in defining: a) how Notch signaling guides and affects the reciprocal interactions between normal or malignant stem cells and their niches; b) Notch signaling and its interplay with the Toll receptors and NF-kB pathways; and c) how this crosstalk is involved in the link between inflammation, aging and leukemia development. To address these questions, we are using complementary approaches including in vivo models of sepsis and leukemia, xenograft models and in vivo multi-model imaging.  The long-term goal of our research is to exploit basic insights in hematopoietic stem cell biology to identify therapeutic targets and test drugs that will target leukemia cells and the inflamed microenvironment.

Selected 20 from ~50 publications

  • Zhang H, Rodriguez S, Wang L, Wang S, Serezani H, Kapur R, Cardoso AA, Carlesso, N. Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88. Stem Cell Reports. 2016 Jun 14;6(6):940-56. doi: 10.1016/j.stemcr.2016.05.002. Epub 2016 Jun 2. PMID: 27264973
  • Pengpeng Bi, Tizhong Shan, Xin Yang, Weiyi Liu, Xin-Rong Liang, Jinghua Wang, Jie Li, Carlesso N., Xiaoqi Liu, Shihuan Kuang. Notch signaling regulates adipose browning and energy metabolism. Nature Medicine, 2014 Jul 20. doi: 10.1038/nm.3615. [Epub ahead of print].
  • Wang L, Rodriguez S, Zhang H, Cao L, Parish J, Mumaw C, Zollman A, Kamoka G, Mu J., Chen D.Z., Srour E, Chitteti B, Hoegenesh H, Boswell S., Manshouri T., Verstovsek S., Yoder M., Kapur R, Cardoso A and Carlesso N. Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in a NF-κB dependent manner. Cell Stem Cell. 2014 Jul 3;15(1):51-65. PMID: 24996169.
  • Rodriguez S., Wang L, Mumaw C, Srour EF, Lo Celso C, Nakayama K, Carlesso N. The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs. Blood. June 2011, 16;117(24):6509-19, 2011. PMCID: PMC312021.
  • Carlesso N. When IFN interferes with cell fate. Blood. 2012 Feb 9;119(6):1327-9. PMID: 22323406
  • Batista A., Barata J., Raderschall E., Sallan SE, Nadler LM., Carlesso N., Cardoso AA. Targeting of activated mTOR inhibits leukemia T-cells and synergizes with cytotoxic Drugs and Signaling Inhibitors. Exp Hematol. Apr 2011;39(4):457-472.e3, 2011. PMID: 21277936.
  • Cheng YH, Chitteti BR, Streicher DA, Morgan, JA, Rodriguez-Rodriguez, Carlesso N, Srour EF, Kacena MA. Impact of maturational status on the ability of osteoblasts to enhance the hematopoietic function of stem and progenitor cells. J Bone Miner Res. May 2011;26(5):1111-21. PMID: 21542011.
  • Carlesso N., Cardoso AA. Stem cell regulatory niches and their role in normal and malignant hematopoiesis. Curr Opin Hematol. July 2010;17(4):281-6. PMID: 20473160.
  • Rodriguez S., Chora A., Goumnerov B., Goebel S., Mumaw C., Fernandez F., Baldini R., HogenEsh H., Doumbousky D., Rice S., Rahme L.G., and Carlesso N. Dysfunctional Expansion of Hematopoietic Stem Cells and Block of Myeloid Differentiation in Lethal Sepsis. Blood. Nov 2009;114(19):4064-76. PMCID: PMC2774548.
  • Fernandez L., Rodríguez S., Huang H., Chora A., Mumaw C., Cruz E., Pollok K, Cristina F., Price J.E., Ferkowitz M.J., Scadden D.T., Clauss M., Cardoso A.A, Carlesso N. TNFα and Endothelial Cells Modulate Notch Signaling in the Bone Marrow Microenvironment during Inflammation. Exp. Hematology. 2008, May; 36(5):545-558. PMID: 18439488.
  • Sarmento L., Huang H., Limon A., Gordon W., Fernandes J., Tavares M.J., Miele L., Cardoso A.A., Classon M., Carlesso N. Notch1 Modulates Timing of G1-S Progression by Inducing SKP2 Transcription and p27Kip1 Degradation. J Exp Med., 2005, 202(1):157-168.
  • Ellisen L.W. #, Carlesso N. #, Scadden, D.T., Haber, D.A. Regulation of Hematopoiesis by the Tumor Suppressor WT1. Embo J., 20 (8): 1897-1909, 2001. # Equal contribution.
  • Lewin M.#, Carlesso N.#, Tung C., Tang X., Cory D., Scadden D., Weissleder R. HIV-TAT Derivatized Magnetic Nanoparticles allow in vivo tracking and recovery of progenitor cells. Nature Biotech., 18(4):410-414, 2000. # Equal contribution.
  • Carlesso N., Aster J., Sklar J., Scadden D. Notch1-Induced Delay of Human Hematopoietic Progenitor Cell Differentiation is Associated with Altered Cell Cycle Kinetics. Blood, 93(3): 838-848, 1999.
  • Bazzoni G.F., Carlesso N. #, Griffin J.D., Hemler M.E. Bcr/Abl expression stimulates integrin function in hematopoietic cell lines. J. Clin. Invest., 98(2): 521-528, 1996. #Equal contribution.
  • Carlesso N., Frank D.A., Griffin J.D. Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J. Exp. Med., 183(3): 811-820, 1996
  • Inhorn R.C., Carlesso N., Durstin M., Frank D.A., Griffin J.D. Identification of a viability domain in the granulocyte/macrophage colony--chain involving tyrosine-750 and SHC. Proc. Natl. Acad. Sci. USA, 92(19): 8665-8669, 1995
  • Carlesso N., Griffin J.D., Druker B.J. Use of a temperature-sensitive mutant to define the biological effects of the p210BCR-ABL tyrosine kinase on proliferation of a factor-dependent murine myeloid cell line. Oncogene, 9(1):149-156, 1994
  • Carlesso N., Pregno P., Bresso P., Gallo E., Pileri A., Zsebo K.M., Ferrero D. Human recombinant stem cell factor stimulates in vitro proliferation of acute myeloid leukemia cells and expands the clonogenic cell pool. Leukemia, 6(7):642-648, 1992
  • Ferrero D., Carlesso N., Pregno P., Gallo E., Pileri A. Self-renewal inhibition of acute myeloid leukemia clonogenic cells by biological inducers of differentiation. Leukemia, 6(2):100-106, 1992
  • 1995, Sandoz Drug Discovery Program Award
  • 1998, American Medical Association Education, F.A. Carter Fellowship in Leukemia Award
  • 1999, Nesson Investigator Award (Massachusetts General Hospital)
  • 1999-2001, Claflin Distinguished Scholar Award-Harvard Medical School 50th Anniversary
  • 2004, Harvard Medical School Leadership Development for Physicians and Scientist
  • 2006, Milton Fund Scholar Award (Harvard University)
  • 2007, Showalter Research Trust Funding Award
  • 2010, IUPUI Women’s Leadership Award
  • 2012, “Exceptional Physician Mentor” recognition. AMA Women Physician Congress - Physician Mentor Recognition Program
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