Research Lab Overview

The long-term goal of our research is to understand the mechanisms regulating normal and malignant hematopoietic stem cells to identify novel approaches for treating bone marrow (BM) failures and leukemias and improving stem cell transplant. We are investigating the role of Notch in maintaining the integrity of the BM niche, the link between inflammation and leukemogenesis, and the contribution of the BM microenvironment and inflammation to leukemia progression and bone marrow failure.

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Nadia Carlesso, M.D., Ph.D.

Professor and Chair, Department of Stem Cell Biology and Regenerative Medicine

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Our Publications

Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium. Nat Commun. 2022 Nov 24;13(1):7235. PMID: 36433940

Kim YW, Zara G, Kang H, Branciamore S, O'Meally D, Feng Y, Kuan CY, Luo Y, Nelson MS, Brummer AB, Rockne R, Chen ZB, Zheng Y, Cardoso AA and Carlesso N.

Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL. Leukemia. 2020 May;34(5):1241-1252. PubMed PMID: 31772299

Rodriguez S, Abundis C, Boccalatte F, Mehrotra P, Chiang MY, Yui MA, Wang L, Zhang H, Zollman A, Bonfim-Silva R, Kloetgen A, Palmer J, Sandusky G, Wunderlich M, Kaplan MH, Mulloy JC, Marcucci G, Aifantis I, Cardoso AA, Carlesso N.

Cytoplasmic DROSHA and non-canonical mechanisms of MiR-155 biogenesis in FLT3-ITD acute myeloid leukemia. Leukemia. 2021 Aug;35(8):2285-2298 PubMed PMID: 33589748

Nguyen LXT, Zhang B, Hoang DH, Zhao D, Wang H, Wu H, Su YL, Dong H, Rodriguez-Rodriguez S, Armstrong B, Ghoda LY, Perrotti D, Pichiorri F, Chen J, Li L, Kortylewski M, Rockne RC, Kuo YH, Khaled S, Carlesso N, Marcucci G.

Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88. Stem Cell Reports. 2016 Jun 14; 6(6):940-56

Zhang, H., Rodriguez, S., Wang, L., Wang, S., Serezani, H., Kapur, R., Cardoso, A.A., and Carlesso, N.

Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner. Cell Stem Cell. 2014 Jul 3;15(1):51-65. PubMed PMID: 24996169

Wang L, Zhang H, Rodriguez S, Cao L, Parish J, Mumaw C, Zollman A, Kamoka MM, Mu J, Chen DZ, Srour EF, Chitteti BR, HogenEsch H, Tu X, Bellido TM, Boswell HS, Manshouri T, Verstovsek S, Yoder MC, Kapur R, Cardoso AA, Carlesso N.

Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Nat Med. 2014 Aug;20(8):911-8. PubMed PMID: 25038826

Bi P, Shan T, Liu W, Yue F, Yang X, Liang XR, Wang J, Li J, Carlesso N, Liu X, Kuang S.