Nadia Carlesso Lab

The long-term goal of our research is to understand the mechanisms regulating normal and malignant hematopoietic stem cells to identify novel approaches for treating bone marrow (BM) failures and leukemias and improving stem cell transplant.  We are investigating the role of Notch in maintaining the integrity of the BM niche, the link between inflammation and leukemogenesis, and the contribution of the BM microenvironment and inflammation to leukemia progression and bone marrow failure.

To view a list of publications, please click on the link below.

CIRM-INFR6.1.15357     08/01/2024 – 07/31/2029
(PI: Carlesso)                
Stem Cell-based Disease Modeling Shared Resource Laboratory

NIH/NCIR01 CA269740-01A1     04/01/2023 – 03/31/2028    
(PI: Carlesso)                
Targeting the Microenvironment Oncogene Cooperation to treat poor prognosis T-ALL    

CIRM EDU4-12772     12/01/2021 – 11/30/2026
(Co-PI: Carlesso)                
Research Training Program in Stem Cell Biology and Regenerative Medicine

CIRM Clin 2 #14068     09/01/2023 – 08/31/2027
(Co-I: Carlesso)                
Treatment of Severe Aplastic Anemia by induction of mixed chimerism using CD4+ T-depleted haploidentical blood stem cell transplant        

CUBRI- COH/UCR Biomedical Research     07/2024 – 06/2025
(MPI: Carlesso, Liu)                
Engineered 3-D Bone Marrow Model for Studying Hematopoiesis and Leukemia