An NCI-designated Comprehensive Cancer Center
Sangeeta Dhawan

Sangeeta Dhawan, Ph.D.

Assistant Professor, Department of Translational Research and Cellular Therapeutics
Research Focus
  • Epigenetics
  • Islet development, function, and survival
  • Diabetes pathogenesis
  • Beta-cell regeneration

Research Teams

  • Translational Research & Cellular Therapeutics
Sangeeta Dhawan received her Ph.D. in molecular and developmental biology from Indian Institute of Science, Bangalore, India, where she studied the developmental regulation of silk gland formation in the silkworm Bombyx mori. She did her postdoctoral training at Harvard Medical School and UCLA.
 
Her training at UCLA focused on understanding the mechanisms of beta cell mass regulation. This work was supported by an advanced postdoctoral fellowship from JDRF. She is also a recipient of the Start-up Award and the Smookler Award for Diabetes Research from the Larry L. Hillblom Foundation, as well as a Transition Award from JDRF. She has served as a reviewer for journals such as Diabetes, and Regulatory Peptides.

Locations

City of Hope Comprehensive Cancer Center, 1500 East Duarte Road

Duarte, CA 91010

  • Rodnoi P., Rajkumar M., Md Moin A.S., Georgia S.K., Butler A.E., Dhawan S. Neuropeptide Y expression marks partially differentiated beta-cells in mice and humans. JCI Insight. 2017; 2(12).
  • Dhawan S., Dirice E., Kulkarni R.N., Bhushan A. Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication. Diabetes. 2016; 65(5):1208-18.
  • Dhawan, S., Tschen, S.I., Zeng, C., Guo, T., Hebrok, M., Matveyenko, A., Bhushan, A. (2015)  DNA methylation directs functional maturation. Of pancreatic beta cells. Journal of Clinical Investigation. 125(7): 2851-2860.
  • Zhou, X., Dhawan, S., Fu H., Kundu, S., Kim, S.K., Bhushan, A. (2013) Polycomb and trithorax regulation of Ink4a to regenerate beta cells. Journal of Clinical Investigation. 123 (11): 4849-4858.
  • Papizan, J.B., Singer, R.A*., Tschen, S.I.*. Dhawan, S*. , Friel, J.M., Hipkins, S.B., Magnuson,  M.A., Bhushan, A., Sussel., L. (2011) Nkx2.2 repressor complex regulates islet  beta cell  specification and prevents beta to alpha cell reprogramming. Genes and Development . 25(21): 2291-2305.
  • Dhawan, S., Georgia, S., Tschen, S.I., Bhushan A. (2011) Pancreatic beta cell identity is  maintained by DNA methylation-mediated repression of Arx . Developmental Cell. 20  (4): 419-429.
  • Dhawan, S., Tschen, S.I., Bhushan A. (2009) Bmi-1 regulates Ink4a/Arf locus to  control pancreatic beta cell proliferation. Genes and Development. 23(8):906-11.
  • Tschen, S. I., Dhawan, S., Gurlo T., Bhushan A. (2009) Age-dependent decline in beta cell proliferation restricts the capacity of beta cell regeneration in mice. Diabetes 58(6):1312-20.
 
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