Colloquium Agenda
Monday, November 6
7:30-8:30 a.m. | Breakfast
Welcome and Introduction to the Colloquium Theme
8:30-9:00 a.m. | Ravi Salgia, M.D.
Session 1: Plasticity and Evolution
Chairperson: Atish Mohanty, Ph.D.
9:00-9:30 a.m. | Gunter Wagner
“The stromal biology regulating cancer malignancy between species.”
9:30-10:00 a.m. | Carlo Maley
10:00-10:30 a.m. | Susan Rosenberg
“The DNA Damageome and Cancer Evolvability”
10:30-11 a.m. - Coffee break
Chairperson: Swapnil Rajurkar, M.D.
11:00-11:30 a.m. | Eugene Koonin
“Coevolution of mobile genetic elements and defense systems: a generator of evolutionary plasticity.”
11:30-12:00 p.m | Aurora Nedelcu
“Stress-induced plastic responses in the evolution of multicellularity and cancer”
12:00-12:30 Panel Discussion
12:30 -2:00 p.m. Lunch break
Session 2: Genetic/Non-genetic Mechanisms Underlying Plasticity
Chairperson: Sudarsan Kollimuttathuillam, M.D.
2:00-2:30 p.m. | Sui Huang
“Non-genetic State transitions in Cancer cells, the Good and Bad - from Theory to Treatment”
2:30-3:00 p.m. | Robert Gatenby
“A tale of two tumors: the evolutionary arcs from normal to malignant phenotypes in breast and lung cancers”
3:00-3:30 p.m. | Trevor A. Graham
“Mechanisms of phenotype adaptation in colorectal cancer”
3:30-4:00 p.m. Coffee break
Chairperson: Jingran Ji
4:00-4:30 p.m. | Jianjun Chen
“RNA Modification in Cancer”
4:30-5:00 | Subhajyoti De
“Transcriptional state dynamics in urothelial bladder carcinoma”
5:00-5:30 p.m. Panel discussion
Tuesday, November 7
7:30-8:30 a.m. | Breakfast
Session 3: Mathematical Modeling of Plasticity
Chairperson: Neel Talwar, M.D.
8:30-9:00 a.m. | Herbert Levine
“Epigenetic modulation of epithelial-mesenchymal plasticity"
9:00-9:30 a.m. | Robert Austin
9:30-10:00 a.m. | Mohit Kumar Jolly
“Systems-level analysis of phenotypic switching in melanoma: from design principles to therapeutic interventions”
10:00-10:30 a.m. Coffee break
Chairperson: Tanyanika Phillips
10:30-11:00 | Michael Elowitz
“The many-to-many protein interaction architecture and multicellularity”
11:00-11:30 | Supriyo Bhattacharya
“Phenotypic switching: A strategy for reversible and rapid adaptation to therapeutic stress”
11:30-12:00 Panel discussion
12:00-12:30 p.m. Group photo
12:30-1:30 p.m. Lunch
Session 4: Conformational Dynamics and Plasticity
Chairperson: Gagandeep Brar, M.D.
1:30-2:00 p.m. | Jasmine Foo
“Modeling plasticity-driven drug resistance evolution”
2:00-2:30 p.m. | Emma Lundberg
“Proteome-wide studies of cell heterogeneity”
2:30-3:00 | John Orban
"Structural plasticity in proteins"
3:00-3:30 Coffee break
Chairperson: Edward Wang
3:30-4:00 p.m. | Tsui-Fen Chou
4:00-4:30 p.m. | Shasha Chong
"Illuminating dark proteome-mediated transcriptional control in cancer by live-cell single-molecule imaging"
4:30-5:00 p.m. Panel discussion
Concluding Remarks and Thanks
5:00-5:15 p.m. | Prakash Kulkarni