
Ajay Goel Lab
Research Highlights
Biomarkers for Diagnosis, Prognosis, Treatment Response and Monitoring
Using a multiplicity of molecular approaches, City of Hope researchers have identified a diverse range of novel colorectal cancer biomarkers, including DNA, mRNA, microRNA and DNA methylation-based biomarkers. The potential clinical applications of these biomarkers are broad, and include diagnosis, prognosis, treatment prediction and monitoring of colorectal and other GI cancers, as well as patient stratification for clinical trials. Notably, most of these biomarkers have been validated using clinical samples from large patient cohorts and have been described in highly regarded peer-reviewed journals. These biomarkers offer three benefits that are key to clinical and commercial success:
- Multiple applications – novel, proprietary biomarkers for diagnosis, prognosis and monitoring of colorectal and other GI cancers
- Stand-alone or multiplexed – the biomarkers can potentially be used in stand-alone assays, or as part of multiplexed assays to achieve greater sensitivity and specificity
- Integration – the biomarkers are compatible with standard molecular platforms and workflows
Epigenetics and Cancer Prevention
Resources available:
- Ion Torrent PGM sequencer
- Ion Chef
- Applied Biosystems 3100 Avant sequencer
- Pyromark PSQ HS 96A pyrosequencing system
- QiaCube automated nucleic acid extraction systems
- QuantStudio digital PCR system
- Applied Biosystems real-time PCR machines
- Fluorescence microscopes
- Digital imaging systems
Professor and Chair in the Department of Molecular Diagnostics and Experimental Therapeutics and Associate Director of Basic Science in the Comprehensive Care Center, Ajay Goel's research focuses on better methods for the early detection and precision treatment of cancer.

Lab Members


Chao Gao, M.D., Ph.D., graduated from Tianjin Medical University in Tianjin, China. During his university years, he researched the interaction between colon cancer-associated fibroblasts and tumor microenvironment, as well as the regulatory mechanism of immune tolerance in organ transplantation. He worked at TMUGH after graduate school as a surgeon in gastrointestinal surgery department. At City of Hope, he hopes to find new biomarkers for early diagnosis and prognosis in gastric, colorectal and other solid organ cancers in the digestive tract, and to explore new immunotherapy targets and chemotherapy resistance mechanisms.


Maaha Khan is a Research Associate I in the Ajay Goel Lab at City of Hope. Maaha Khan graduated from McGill University with a B.S. in Biology and Mathematics with concentrations in Neuroscience and Statistics. During her undergraduate degree, she had multiple research internships where she worked on projects focusing on lymphocytic lymphoma and immune cell states in brain tumors. In her free time, she enjoys dancing and going to the beach.


Minghan Li, M.D. Ph.D. is a Global Scholar in the Ajay Goel Lab at City of Hope, Duarte, CA. She is also a candidate at Fudan University Shanghai Cancer Center. Her research focuses on colorectal cancer, especially tumor metastasis and precision oncology involving multi-omic analysis. In her spare time, she enjoys swimming, skiing, and hiking with friends.


Yuan Li, a Ph.D. candidate at Tongji University, is dedicated to her current research, which revolves around understanding the intricacies of gastrointestinal cancer metastasis and the development of resistance to cancer treatments.
Her main goal is to enhance the understanding of molecular and immune biomarkers present in tissue and blood samples. This work aims to improve the accuracy of precision diagnostics and treatment strategies for gastrointestinal cancer.
Outside of her research endeavors, she finds joy in activities such as hiking and traveling.


Takayuki Noma, M.D., graduated from Tokushima University of Medicine in Japan. In Japan he worked as a digestive surgeon.
He played rugby football at university and enjoys fishing and cooking.


Roxanna Razavi is a Research Associate in the Ajay Goel Lab at the City of Hope, Duarte, CA.


Silei Sui graduated from Dalian Medical University with a Ph.D. in oncology and worked on the molecular mechanism and clinical significance of colorectal cancer before joining City of Hope. After graduation, she worked as a visiting postdoctoral under the guidance of Ajay Goel, Ph.D., M.S., at City of Hope. She aims to identify clinical biomarkers for improving the survival and treatment effect of colorectal cancer based on a multi-omics NGS approach.
Sui is skilled in Python, R, and machine learning and experienced in the biological analysis of genome sequencing, transcriptional sequencing and single-cell sequencing data.
Outside of work, she enjoys fitness and listening to music.


Koichi Takiguchi, MD, Ph.D. is a global scholar in the Ajay Goel Lab at City of Hope, Duarte, CA. He graduated from Fukushima Medical University in Japan and belong to the First Department of Surgery, Faculty of Medicine, University of Yamanashi. He is a gastrointestinal surgeon specializing in the lower gastrointestinal tract.


Junyong Weng, M.D. Ph.D. is a Global Scholar in the Ajay Goel Lab at City of Hope, Duarte, CA. Junyong Weng, M.D., Ph.D, earned a Ph.D. from Fudan University, specializing in metastatic colorectal cancer and immunotherapy research. During his time at City of Hope, under the mentorship of Professor Goel, he focuses on developing biomarkers for predicting treatment responses in colorectal cancer and identifying potential therapeutic targets. Outside of work, he enjoys staying active through sports and exploring his passion for cooking.


Jiabei Zhu is a Global Scholar in the Ajay Goel Lab at City of Hope, Duarte, CA.
Lab Alumni
- Minghan Li, M.D., Ph.D., Global Scholar, 2024
- Kainan Wang, M.D., Global Scholar, 2024
- Caiming Xu, Postdoctoral Fellow, 2021-2024
- Takahiro Shinozuka, M.D., Global Scholar, 2024
- Ying Jin, M.D., Global Scholar, 2024
- Shalini Shah, Research Associate I and Lab Manager, 2023-2024
- Kazuki Wakizaka, M.D., Ph.D., Global Scholar, 2023-2024
- Fei Lin, M.D., Ph.D., Global Scholar, 2023-2024
- Alessandro Mannuccci, Global Scholar, 2023-2024
- Katsutoshi Shoda, 2023-2024
- Takumi Onoyama, 2023-2024
- Hongxia Duan, 2023-2024
- Yoh Asahi, 2022-2023
- Qinghua Huang, Global Scholar, 2022-2023
- Jiang Li, Global Scholar, 2022-2023
- Katsuki Miyazaki, Postdoctoral Fellow 2021-2023
- Keisuke Okuno, Assistant Professor 2021-2023
- Milad Moloudizargari, Postdoctoral Fellow, 2021-2022
- Manikandan Murugesan, Postdoctoral Fellow, 2021-2022
- Kota Nakamura, Visiting Scholar, 2021-2022
- Viktor Hlavac, Visiting Scholar, 2021-2022
- Jasmine Kasanke, Research Associate II, 2021-2022
- Nour-Lynn Mouallem, Research Associate, 2021-2022
- Nadia Houerbi, Research Associate II, 2021-2022
- Souvik Ghatak, Postdoctoral Fellow, 2020-2022
- Souvick Roy, Postdoctoral Fellow, 2020-2022
- Samarjit Sambanduram, Research Associate II, 2018-2022
- Tikam Dakal, Staff Scientist, 2022
- Hiroyuki Hanayama, Visiting Scholar, 2022
- Yinghui Zhao, Visiting Scholar, 2020-2021
- Long Vu, Research Associate II, 2020-2021
- Anthony Chonopoulos, Postdoctoral Fellow, 2020-2021
- Divya Sahu, Postdoctoral Fellow, 2020-2021
- Rachana Garg, Staff Scientist, 2020-2021
- In Seob Lee, Visiting Scholar, 2019-2021
- Geeta Sharma, Postdoctoral Fellow, 2019-2021
- Yuma Wada, Visiting Scholar, 2019-2021
- Zhongxu Zhu, Visiting Graduate Researcher, 2021
- Yogi Pratama, Postdoctoral Fellow, 2021
- Yuki Sanagawa, Visiting Scholar, 2021
- Yu Chen, Visiting Graduate Researcher, 2021
- Huanlin Wang, Visiting Scholar, 2019-2020
- Yasuyuki Okada, Visiting Scholar, 2019-2020
- Satoshi Nishiwada, Visiting Scholar, 2018-2020
- Tatsuhiko Kakisaka, Visiting Scholar, 2018-2020
- Yasheshwari Tripathi, Research Associate I, 2017-2020
- Francis Maria Esposito, Visiting Scholar, 2020
- Xiaoe Zhang, Postdoctoral Fellow, 2020
- Yuetong Chen, Visiting Graduate Researcher, 2020
- Ravi Yadav, Research Associate I, 2018-2019
- Tong Liu, Visiting Scholar, 2017-2019
Current Funding
These organizations are invaluable partners in our work toward progressing the development of new treatments in our specialized areas of research.

Our Publications
Latest Research News

The researchers looked at 210 plasma samples from pancreatic ductal adenocarcinoma patients, some of whom had neoadjuvant treatment (NAT) ...

Dr. Ajay Goel highlighted the importance of colon cancer screenings and provided insight on the new screening guidelines for patients.

DDW 2021 abstract - Transcriptomic Profiling Identifies a Risk Stratification Signature for Predicting Peritoneal Recurrence and Micrometastasis in Gastric Cancer

According to the American Cancer Society, there will be about 150,000 new cases of colon cancer this year alone, and more than 50,000 deaths.

Assessment of the Diagnostic Efficiency of a Liquid Biopsy Assay for Early Detection of Gastric Cancer
Contact Information
34.1381007, -118.0199764
Monrovia, CA 91016