Lee Jones Lab
Research Lab Overview
We conduct translational-driven clinical trials in exercise oncology across diverse populations throughout the cancer continuum. Our studies are designed using the same rigorous methodologies as drug trials, enabling us to investigate the relationship between exercise and cancer. We evaluate the biological activity, safety and feasibility of exercise therapy, while also identifying optimal dosing and the types of cancer patients who might respond best to these interventions.
Our model employs a digitized, decentralized approach to deliver a patient‑centric experience during high‑fidelity data collection. We provide participants with all necessary devices, allowing them to engage in the trial from the comfort of their homes.
Clinical trial participants complete testing to assess baseline exercise capacity and establish individualized training zones. Participants enrolled in the same protocol receive a similar exercise prescription scaled relative to their fitness level. Our exercise physiologists provide session guidance and monitor participants throughout treadmill walking sessions. This real‑time oversight enables exercise titration, e.g., when a participant is unable to tolerate a session or when the prescribed intensity does not elicit the intended physiological benefit.
Additionally, we study health technology data to evaluate its potential to improve prognostication across multiple oncology settings. These data are passively collected via cellphones and wearable devices, such as smartwatches, and typically include measuring mobility (sleep, sedentary time and physical activity) and heart rate. Together, these metrics facilitate digital physiological phenotyping.
Our goal is to generate evidence‑based insights that enable clinicians to deliver personalized patient care.
Research Areas
Our research program focuses on evaluating exercise as a cancer prevention and therapeutic modality. Our investigative workflow begins with epidemiological analyses that identify potential associations between exercise behaviors and cancer incidence or progression pathways. These observations are then tested in mechanistic preclinical models to determine the robustness and directionality of the underlying signaling effects. We advance findings that demonstrate biological promise to clinical trials that sequentially assess safety, feasibility, appropriate dosing, and ultimately, therapeutic efficacy.
Within a co-clinical trial of women at high risk for breast cancer, we observed that six months of aerobic exercise therapy demonstrated biological efficacy in a nonlinear (curvilinear) manner. An exercise dose of 150 minutes per week promoted antitumor efficacy; however, doubling the dose to 300 minutes per week provided no additional benefit, at least with respect to Ki67 reductions in humans and increased tumor latency in the selected preclinical model.
In a dose-finding trial of men undergoing active surveillance for localized prostate cancer, neoadjuvant aerobic exercise was feasible and well tolerated. Exercise doses ranging from 225 to 375 minutes per week were associated with reductions in Ki67 and PSA, yielding promising biological signals. Based on these findings, we selected 225 minutes per week as the recommended Phase 2 exercise dose.
Lee Jones, Ph.D., is a professor in the Department of Population Sciences’ Division of Outcomes Research at City of Hope® Cancer Center Duarte. An internationally renowned physician-scholar in the field of exercise science, Dr. Jones leads the Exercise Oncology Program, a translational research initiative at City of Hope’s Beckman Research Institute that investigates the effects and mechanisms of structured exercise therapy on the development and treatment of cancer, with a particular emphasis on clinical outcomes for high-risk patients.
Lab Members
Jaron Arbet, Ph.D., is passionate about applying statistics, data
...Jaron Arbet, Ph.D., is passionate about applying statistics, data science and software development to advance cancer research and improve public health. He earned his doctorate in biostatistics from the University of Minnesota Twin Cities in Minneapolis, Minnesota, and has extensive experience in biostatistics, bioinformatics and machine learning across academic medical centers, cancer research institutes and industry. His work includes leading multi-omics analyses, contributing to clinical and translational research and collaborating on interdisciplinary scientific projects. Since joining City of Hope in 2025 as an assistant research professor and biostatistician, Dr. Arbet has developed advanced analytical methods to support exercise oncology research by integrating clinical, molecular and behavioral data.
Catherine Lee earned her Master of Public Health degree from New
...Catherine Lee earned her Master of Public Health degree from New York University in New York, New York. She has extensive experience in regulatory and operational oversight of therapeutic oncology trials, with a focus on exercise and nutritional medicine. She joined City of Hope as program director of the Exercise Oncology Program in July 2025, leading the protocol development process and overseeing the clinical trial portfolio. Her other duties include implementing digital and telehealth initiatives, managing vendor and analytical collaborator relationships and ensuring quality assurance and regulatory compliance throughout the life cycles of clinical trials.
Amanda O’Meara earned her Bachelor of Science from the State
...Amanda O’Meara earned her Bachelor of Science from the State University of New York at Oneonta (SUNY Oneonta) in Oneonta, New York. She became a Clinical Research Coordinator in 2024, during which she facilitated patient care for exercise therapy trials while maintaining strict protocol and regulatory compliance. Amanda joined City of Hope in August 2025. In the Exercise Oncology Program, she manages clinical trial participants and oversees protocol compliance as a clinical research assistant.
Gabrielle Cervantes holds a Bachelor of Science in Psychobiology
...Gabrielle Cervantes holds a Bachelor of Science in Psychobiology from the University of California, Los Angeles, in Los Angeles, California, with a focus on medicine. She recently completed a postbaccalaureate program in general and medical sciences through UCLA Extension. Her professional background includes laboratory and COVID-19 research prior to transitioning into solid tumor oncology clinical trials and exercise oncology. As a clinical research assistant, she supports study coordination and data management to evaluate the impact of physical activity on cancer patient outcomes. Gabrielle joined City of Hope in July 2024 as an associate clinical research coordinator within the Clinical Trials Office and transitioned to the Exercise Oncology team in September 2025.
Meghan Michalski holds a Master of Science in Clinical Exercise
...Meghan Michalski holds a Master of Science in Clinical Exercise Physiology from the University of Wisconsin-La Crosse in La Crosse, Wisconsin. She has extensive experience in cardiopulmonary exercise testing, vascular assessments and exercise training for individuals with chronic health conditions. Meghan joined City of Hope in July 2025 as the supervisor of exercise physiology. Within the Exercise Oncology Program, she leads the exercise physiologist team and contributes to the development and implementation of exercise prescription protocols, workflows and operational procedures to support high-quality research.
Dale Holsombeck Jr., M.A., earned his Master of Arts in Exercise
...Dale Holsombeck Jr., M.A., earned his Master of Arts in Exercise Physiology from the University of Alabama Tuscaloosa, Alabama, in 2021. He has extensive experience in cardiopulmonary and metabolic stress testing, as well as physical rehabilitation settings. In 2023, Dale joined the Lee Jones Laboratory at Memorial Sloan Kettering Cancer Center in New York, New York, as an Exercise Physiologist, where he administered physiological testing and developed individualized training programs for diverse cancer populations enrolled in multiple clinical trials. He continued in this role at City of Hope in August 2025.
Laken Hill earned her Master of Science in Exercise Oncology from
...Laken Hill earned her Master of Science in Exercise Oncology from Saint Francis University in Loretto, Pennsylvania. She has experience in cardiac stress testing and in delivering personalized exercise interventions to patients across the cancer continuum. Laken joined City of Hope in August 2025. Within the Exercise Oncology Program, she conducts exercise training and testing sessions across all research protocols, ensuring accurate delivery, documentation and adherence to study procedures.
Christian Hipolito earned his Bachelor of Science in Kinesiology
...Christian Hipolito earned his Bachelor of Science in Kinesiology from California State University, Long Beach, in Long Beach, California, where he contributed to research in exercise and cardiometabolic health. Prior to joining City of Hope, he worked as an exercise physiologist providing individualized exercise programming for diverse clinical populations, including oncology patients. Christian joined City of Hope in January 2026. He supports oncology research by delivering protocol-based exercise training, performing physiological assessments and ensuring study quality and participant safety.
Marie Montgomery holds a Bachelor of Science in Communications.
...Marie Montgomery holds a Bachelor of Science in Communications. She joined City of Hope in 2013 and began her career in Research Administration. As a Senior Business Manager, she provides administrative and operational support to multiple faculty members, postdoctoral fellows and research associates. Her responsibilities include overseeing daily departmental operations to ensure objectives and deadlines are met; managing contract and grant proposal submissions, awards, expenditures and extramural funding; and supervising workflow across support staff and multiple principal investigators. She also coordinates with centralized offices and supports short- and long-term administrative decision making while resolving budgetary, human resources, grant and laboratory operations issues across the full grant life cycle.
Vero Rodriguez holds a Bachelor of Science in Childhood and
...Vero Rodriguez holds a Bachelor of Science in Childhood and Adolescent Development and a Master of Science in Child Life. She joined City of Hope in 2022 and began her career in Research Administration. As a research operations analyst, Vero is responsible for reviewing, monitoring and processing internal contracts and managing pre- and post-award sponsored research activities to ensure objectives and deadlines are consistently met.
The Exercise Oncology Research Program is always interested in recruiting top talent. Please submit inquires and CVs via email.
Our Publications
Media Highlights
- Dr. Jones discusses how exercise science is helping reshape cancer treatment and care, highlighting the challenges and breakthroughs in establishing exercise as a vital part of oncology research. Check out the episode of "On the Edge of Breakthrough: Voices of Cancer Research."
- Dr. Jones is one of the experts for the Sept. 29, 2025, City of Hope Breast Cancer Forum: Exercise and Integrative Medicine in Breast Cancer Research and Care. Watch video below:
Latest Research News
Contact Information
34.1293487, -117.9726643
Duarte, CA 91010