The Chen laboratory is interested in discovering novel genetic/epigenetic regulations and the associated molecular mechanisms of both protein-coding genes and noncoding RNAs (e.g., microRNAs) in normal developmental processes (e.g., hematopoiesis) and tumorigenesis (e.g., leukemogenesis). In recent years, Chen and colleagues have been focusing on both basic and translational research associated with RNA/DNA epigenetics, especially RNA methylation/demethylation related to the N6 methyladenosine (m6A) machinery and DNA demethylation related to the TET1/2/3 family, and have developed several small-molecule compound inhibitors to selectively target cancer-related RNA/DNA epigenetic modifiers that hold therapeutic potential. The ultimate goal of the lab is to translate the laboratory discoveries into the development of effective novel therapeutic strategies to treat cancers, especially acute leukemia, in the clinic.
Professor and Chair of the Department of Systems Biology, Jianjun Chen conducts research that focuses on systems biology. He received his Ph.D. from Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai, China, and then conducted postdoctorate training with Dr. Janet D. Rowley at University of Chicago, Department of Medicine where he launched his independent laboratory in 2009.
2020-present, Ph.D. candidate, Hematology, Fujian Medical University, Fuzhou, Fujian, China
2014, B.S. and M.D., Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, China
2021-present, Visiting Scholar, Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA
2018-present, Attending Physician, Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China
2014, Outstanding Graduate Student of Fujian Medical University
2012, National Scholarship for Graduate Students
2020-present, Secretary of the Youth Committee of the Hematology Physician of Fujian Medical Association
The effect of interfering TGF-β receptor ǁ expression on NB4 cells proliferation and different response to ATRA and ATO. Chin J Pathol. 2018, 34(10): 1729-1735.
Chen M, Zhang S, Chen Y, Guo Y, Wu Y.
Expression and role of granulocyte macrophage colony-stimulating factor receptor (GM-CSFR) and granulocyte colony-stimulating factor receptor(G-CSFR) on Ph-positive acute B lymphoblastic leukemia. Hematology. 2018, 23(8): 439-447.
Tan M, Chen M, Chen Y, Wu Y.
Ying Qing, M.D., completed her clinical medical training and obtained her M.D. degree under the guidance of Dr. Min Wang at Shandong University, China, before moving to City of Hope to pursue her Ph.D. During her M.D. training, her major interest was the effect of the phytochemical sulforaphane on chemoprevention of colorectal cancer and its epigenetic mechanism. She also studied the correlation between H. pylori related gastric diseases and colorectal neoplasia. Qing gained great interest in the epigenetic mechanisms of carcinogenesis through these trainings, and joined the lab of Jianjun Chen, Ph.D., the Simms/Mann Family Foundation Chair in Systems Biology, to conduct her Ph.D. research to be further trained in the field of DNA/RNA epigenetics of leukemogenesis and/or solid cancer development. Her current work focuses on understanding of roles of different RNA epigenetic players, especially m6A readers and their potential co-factors, in acute myeloid leukemia development.