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Vu Nguyen Ngo Lab

The research program in the Ngo laboratory is focused on pathogenetic mechanisms and identification of molecular targets in aggressive lymphoid malignancies.
Research Lab Overview

Vu Nguyen Ngo completed his Ph.D. degree in the laboratory of Jason Cyster at the University of California San Francisco, where he studied the molecular basis of lymphoid tissue organization through interactions of lymphocytes with stromal cells and the chemokines and cytokines they secret. He then joined the laboratory of Louis Staudt at the National Institute of Health, National Cancer Institute for postdoctoral training, where he developed an expertise in large-scale functional genomics research, using RNA interference technology to identify functionally important pathways that harbor oncogenic mutations driving lymphomagenesis in diffuse large B cell lymphomas.

In 2010, Dr. Ngo was recruited to start his independent laboratory in the Division of Stem Cell and Leukemia Research at Beckman Research Institute of City of Hope. His laboratory has discovered an important role for recurrent mutations of cyclin D1, which results in deregulated protein turnover and therapy resistance in mantle cell lymphoma. In 2017, Dr. Ngo joined the Department of Systems Biology where he will use innovative functional genomics tools and powerful animal modeling using relevant patient-derived lymphoma samples to gain new insights into critical signaling pathways that are important in lymphomagenesis and resistance to therapy. Dr. Ngo is an award recipient of the American Society of Hematology Scholar Award, the Gabrielle’s Angel Foundation for Cancer Research, the Department of Defense’s Career Development, and the Concern Foundation for Cancer Research.

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Principal Investigator: Vu Nguyen Ngo, Ph.D.

An associate professor in the Department of Systems Biology, Vu Nguygen Ngo, Ph.D.'s research focuses on molecular pathogenesis of lymphoid malignancies.

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Vu Nguyen Ngo, Ph.D., Associate Research Professor, Department of Systems Biology Full Bio
Lab Members
Serene Xavier, Ph.D.
Postdoctoral Fellow
Research Focus Understanding the mechanistic roles of oncogenic proteins in B cell receptor signaling in mantle cell lymphoma (MCL) Dissecting the function of MCL-specific oncogenic proteins in new genetic mouse models for MCL Education 2019, Ph.D. – Molecular Medicine, Amrita Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, India 2011, M.S. – Biotechnology, Cochin University of Science and Technology, India 2009, B.S. Botany, Mahatma Gandhi University, India Professional Experience 2021-present, Postdoctoral Fellow, City of Hope Biomedical Research Center, Monrovia, California 2019-2020, Postdoctoral Research Associate, National Centre for Biological Sciences, Bangalore, India Awards Council of Scientific and Industrial Research-University Grants Commission National Fellowship for Ph.D. and National Eligibility Test Award for Lectureship, India Marie Skłodowska-Curie Actions Seal of Excellence Award by European Commission Young Fellow Travel Grant Award for Molecular Analysis for Personalised Therapy conference organized by ESMO, UNICANCER and CRUK, Switzerland Botany Silver Jubilee Award for Best Student With Excellence in Academic and Co-Curricular Activities, India Memberships European Association for Cancer Research Publications Xavier S, Mohan CG, Nair S, Menon K, Vijayachandran LS. Generation of humanized single-chain fragment variable immunotherapeutic against EGFR variant III using baculovirus expression system and in vitro validation. International Journal of Biological Macromolecules (2019) 124:17–24. Xavier S, Sundaram KR, Biswas L, Panikar D, Rajamma BM, Nair S, Menon K, Vijayachandran LS. Molecular analysis of oncogene expressions in different grades of gliomas. Journal of Integrated Omics (2018) 8:66-73. doi:10.5584/jiomics.v8i1.242. Xavier S, Sadanandan J, George N, Paulose CS. β2-adrenoceptor and insulin receptor expression in the skeletal muscle of streptozotocin induced diabetic rats: antagonism by vitamin D3 and curcumin. European Journal of Pharmacology (2012) 687:14-20. doi: 10.1016/j.ejphar.2012.02.050. Conference Proceedings Xavier S, Mohan CG, Nair S, Menon K, Vijayachandran LS. Generation of recombinant antibody variable fragments in baculovirus expression system targeted against epidermal growth factor receptor mutant expressing glioblastoma. ESMO Open (2018). doi: 10.1136/esmoopen-2018-EACR25.543. Xavier S, Sundaram KR, Panikar D, Nair S, Menon K, Vijayachandran LS. Molecular analysis of epidermal growth factor receptor (EGFR) gene expression in different grades of gliomas: Critical oncogene for therapy using medicinal plants. Journal of Ayurveda and Integrative Medicine (2018) 9(2). doi: 10.1016/j.jaim.2018.02.048. Xavier S, Sundaram KR, Panikar D, Nair S, Menon K and Vijayachandran LS. Molecular analysis of Epidermal growth factor receptor variant III and glucose transporter expressions in different grades of glioma: potential biomarkers for targeted therapy. Annals of Oncology (2017) 28(7). doi: org/10.1093/annonc/mdx511.028. Xavier S, Nair S, Panikar D, Vijayakumar DK, Anupama R, Vijayachandran LS, Menon K. Importance of Epidermal Growth Factor Receptor variant III (EGFRvIII) mutant in human carcinomas. International Conference Proceedings on Biotechnology for Innovative applications (2013), pp 50-52, Elsevier, New York.
Vivian Nguyen | Research Associate I | Monrovia, CA | Beckman Research Institute of City of Hope
Vivian Nguyen
Research Associate I
Research Focus Mechanistic study of B cell receptor signaling in mantle cell lymphoma Education 2021, B.S., Biochemistry, University of California Riverside, Riverside, California Professional Experience 2021‐present, Research Associate I, Department of Systems Biology, City of Hope, Monrovia, California
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Hongyu Bao, M.D.
Visiting Scholar
Research Focus: Mechanisms and molecular targets in therapy-resistant multiple myeloma
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Our Publications
Regulation of SOX11 expression through CCND1 and STAT3 in mantle cell lymphoma. Blood, 133(4), 306–318. (2019)

Mohanty A, Sandoval N, Phan A, Nguyen TV, Chen RW, Budde E, Mei M, Popplewell L, Pham LV, Kwak LW, Weisenburger DD, Rosen ST, Chan WC, Müschen M, Ngo VN

Cyclin D1 depletion induces DNA damage in mantle cell lymphoma lines. Leuk Lymphoma. 58(3):676-688 (2017).

Mohanty S, Mohanty A, Sandoval N, Tran T, Bedell V, Wu J, Scuto A, Weisenburger D, Ngo VN

CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma. Oncotarget. 7(45):73558-73572 (2016).

Mohanty A, Sandoval N, Das M, Pillai R, Chen L, Chen RW, Amin HM, Wang M, Marcucci G, Weisenburger DD, Rosen ST, Pham LV, Ngo V

Identification of pathogenetically relevant genes in lymphomagenesis by shRNA library screens. Methods Mol Biol. 971:245-63 (2013).

Ngo VN

Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma. Cancer Cell. 23(4):435-49 (2013).

Lamy L, Ngo VN, Emre TNC, Shaffer AL, Yang Y, Tian E, Shaughnessy JD, Nair V, Kruhlak MJ, Zingone A, Landgren O, Staudt LM

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