Recent Publications

  1. Raoof, M., & Singh, G. (2018). In reply. JAMA Surg, 153(1), 92. https://doi.org/10.1001/jamasurg.2017.3480
  2. Raoof, M., Ituarte, P.H.G., Woo, Y., Warner, S.G., Singh, G., Fong, Y., & Melstrom, L. (2018). Propensity score-matched comparison of oncological outcomes between laparoscopic and open distal pancreatic resection. British Journal of Surgery, 105(5), 578-86. https://doi.org/10.1002/bjs.10747
  3. Armenian, S.H., Mertens, L., Slorach, C., Venkataraman, K., Mascarenhas, K., Nathwani, N., Wong, F.L., Forman, S.J., & Bhatia, S. (2018). Prevalence of anthracycline-related cardiac dysfunction in long-term survivors of adult-onset lymphoma. Cancer, 124(4), 850-7. https://doi.org/10.1002/cncr.31110
  4. Pal, S.K., Patel, J., He, M., Foulk, B., Kraft, K., Smirnov, D.A., Twardowski, P., Kortylewski, M., Bhargava, V., & Jones, J.O. (2018). Identification of mechanisms of resistance to treatment with abiraterone acetate or enzalutamide in patients with castration-resistant prostate cancer (CRPC). Cancer, 124(6), 1216-24. https://doi.org/10.1002/cncr.31161
  5. Sedrak, M.S., & Hurria, A. (2018). Cancer in the older adult: Implications for therapy and future research. Cancer, 124(6), 1108-10. https://doi.org/10.1002/cncr.31236
  6. Armenian, S.H. (2018). Health equity for displaced children with cancer in the Middle East. Cancer, 124(7), 1322-5. https://doi.org/10.1002/cncr.31268
  7. McCune, J.S. (2018). Rapid Advances in Immunotherapy to Treat Cancer. Clinical Pharmacology and Therapeutics, 103(4), 540-4. https://doi.org/10.1002/cpt.985
  8. Dalasanur Nagaprashantha, L., Adhikari, R., Singhal, J., Chikara, S., Awasthi, S., Horne, D., & Singhal, S.S. (2018). Translational opportunities for broad-spectrum natural phytochemicals and targeted agent combinations in breast cancer. International Journal of Cancer, 142(4), 658-70. https://doi.org/10.1002/ijc.31085
  9. Kusmartseva, I., Beery, M., Philips, T., Selman, S., Jadhav, P., Wasserfall, C., Muller, A., Pugliese, A., Longmate, J.A., Schatz, D.A., Atkinson, M.A., & Kaddis, J.S. (2018). Hospital time prior to death and pancreas histopathology: implications for future studies. Diabetologia, 61(4), 954-8. https://doi.org/10.1007/s00125-017-4494-x
  10. Rodgers, K., & Jadhav, S.S. (2018). The application of mesenchymal stem cells to treat thermal and radiation burns. Advanced Drug Delivery Reviews, 123, 75-81. https://doi.org/10.1016/j.addr.2017.10.003
  11. Salgia, R., Kulkarni, P., & Gill, P.S. (2018). EphB4: A promising target for upper aerodigestive malignancies. Biochimica et Biophysica Acta - Reviews on Cancer, 1869(2), 128-37. https://doi.org/10.1016/j.bbcan.2018.01.003
  12. Chikara, S., Nagaprashantha, L.D., Singhal, J., Horne, D., Awasthi, S., & Singhal, S.S. (2018). Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment. Cancer Letters, 413, 122-34. https://doi.org/10.1016/j.canlet.2017.11.002
  13. Su, R., Dong, L., Li, C., Nachtergaele, S., Wunderlich, M., Qing, Y., Deng, X., Wang, Y., Weng, X., Hu, C., Yu, M., Skibbe, J., Dai, Q., Zou, D., Wu, T., Yu, K., Weng, H., Huang, H., Ferchen, K., Qin, X., Zhang, B., Qi, J., Sasaki, A.T., Plas, D.R., Bradner, J.E., Wei, M., Marcucci, G., Jiang, X., Mulloy, J.C., Jin, J., He, C., & Chen, J. (2018). R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling. Cell, 172(1-2), 90-105.e23. https://doi.org/10.1016/j.cell.2017.11.031
  14. Xiao, G., Chan, L.N., Klemm, L., Braas, D., Chen, Z., Geng, H., Zhang, Q.C., Aghajanirefah, A., Cosgun, K.N., Sadras, T., Lee, J., Mirzapoiazova, T., Salgia, R., Ernst, T., Hochhaus, A., Jumaa, H., Jiang, X., Weinstock, D.M., Graeber, T.G., & Müschen, M. (2018). B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell, 173(2), 470-84.e18. https://doi.org/10.1016/j.cell.2018.02.048
  15. Li, S., Ali, S., Duan, X., Liu, S., Du, J., Liu, C., Dai, H., Zhou, M., Zhou, L., Yang, L., Chu, P., Li, L., Bhatia, R., Schones, D.E., Wu, X., Xu, H., Hua, Y., Guo, Z., Yang, Y., Zheng, L., & Shen, B. (2018). JMJD1B Demethylates H4R3me2s and H3K9me2 to Facilitate Gene Expression for Development of Hematopoietic Stem and Progenitor Cells. Cell Reports, 23(2), 389-403. https://doi.org/10.1016/j.celrep.2018.03.051
  16. Wang, T., Fahrmann, J.F., Lee, H., Li, Y.J., Tripathi, S.C., Yue, C., Zhang, C., Lifshitz, V., Song, J., Yuan, Y., Somlo, G., Jandial, R., Ann, D., Hanash, S., Jove, R., & Yu, H. (2018). JAK/STAT3-Regulated Fatty Acid beta-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance. Cell Metabolism, 27(1), 136-50.e5. https://doi.org/10.1016/j.cmet.2017.11.001
  17. Pal, S.K., Ali, S.M., Yakirevich, E., Geynisman, D.M., Karam, J.A., Elvin, J.A., Frampton, G.M., Huang, X., Lin, D.I., Rosenzweig, M., Lipson, D., Stephens, P.J., Ross, J.S., Miller, V.A., Agarwal, N., Shuch, B., Choueiri, T.K., & Chung, J.H. (2018). Characterization of Clinical Cases of Advanced Papillary Renal Cell Carcinoma via Comprehensive Genomic Profiling. European Urology, 73(1), 71-8. https://doi.org/10.1016/j.eururo.2017.05.033
  18. Dizman, N., Bergerot, P., Bergerot, C., Lanman, R.B., Raymond, V.M., Banks, K.C., Jones, J., & Pal, S.K. (2018). Exceptional Response to Nivolumab Rechallenge in Metastatic Renal Cell Carcinoma with Parallel Changes in Genomic Profile. European Urology, 73(2), 308-10. https://doi.org/10.1016/j.eururo.2017.08.006
  19. Maia, M.C., Grivas, P., Agarwal, N., & Pal, S.K. (2018). Circulating Tumor DNA in Bladder Cancer: Novel Applications and Future Directions. European Urology, 73(4), 541-2. https://doi.org/10.1016/j.eururo.2017.10.011
  20. Shahin, S.A., Wang, R., Simargi, S.I., Contreras, A., Parra Echavarria, L., Qu, L., Wen, W., Dellinger, T., Unternaehrer, J., Tamanoi, F., Zink, J.I., & Glackin, C.A. (2018). Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer. Nanomedicine: Nanotechnology, Biology, and Medicine, 14(4), 1381-94. https://doi.org/10.1016/j.nano.2018.04.008
  21. Weng, H., Huang, H., Wu, H., Qin, X., Zhao, B.S., Dong, L., Shi, H., Skibbe, J., Shen, C., Hu, C., Sheng, Y., Wang, Y., Wunderlich, M., Zhang, B., Dore, L.C., Su, R., Deng, X., Ferchen, K., Li, C., Sun, M., Lu, Z., Jiang, X., Marcucci, G., Mulloy, J.C., Yang, J., Qian, Z., Wei, M., He, C., & Chen, J. (2018). METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m(6)A Modification. Cell Stem Cell, 22(2), 191-205.e9. https://doi.org/10.1016/j.stem.2017.11.016
  22. Brown, C.E., Aguilar, B., Starr, R., Yang, X., Chang, W.C., Weng, L., Chang, B., Sarkissian, A., Brito, A., Sanchez, J.F., Ostberg, J.R., D'Apuzzo, M., Badie, B., Barish, M.E., & Forman, S.J. (2018). Optimization of IL13Ralpha2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma. Molecular Therapy, 26(1), 31-44. https://doi.org/10.1016/j.ymthe.2017.10.002
  23. Zhao, X., Zhang, Z., Moreira, D., Su, Y.L., Won, H., Adamus, T., Dong, Z., Liang, Y., Yin, H.H., Swiderski, P., Pillai, R.K., Kwak, L., Forman, S., & Kortylewski, M. (2018). B Cell Lymphoma Immunotherapy Using TLR9-Targeted Oligonucleotide STAT3 Inhibitors. Molecular Therapy, 26(3), 695-707. https://doi.org/10.1016/j.ymthe.2018.01.007
  24. Chlebowski, R.T., & Pan, K. (2018). Complexity of intermittent letrozole adjuvant therapy. Lancet Oncology, 19(1), 13-5. https://doi.org/10.1016/s1470-2045(17)30854-9
  25. Van Haute, D., Liu, A.T., & Berlin, J.M. (2018). Coating Metal Nanoparticle Surfaces with Small Organic Molecules Can Reduce Nonspecific Cell Uptake. ACS Nano, 12(1), 117-27. https://doi.org/10.1021/acsnano.7b03025
  26. Wang, L., & Muschen, M. (2018). Portending death in germinal centers - when B cells know their time is up. Cell Research, 28(1), 5-6. https://doi.org/10.1038/cr.2017.151
  27. Kumar, B., Garcia, M., Weng, L., Jung, X., Murakami, J.L., Hu, X., McDonald, T., Lin, A., Kumar, A.R., Digiusto, D.L., Stein, A.S., Pullarkat, V.A., Hui, S.K., Carlesso, N., Kuo, Y.H., Bhatia, R., Marcucci, G., & Chen, C.C. (2018). Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion. Leukemia, 32(3), 575-87. https://doi.org/10.1038/leu.2017.259
  28. Miao, Y., Ajami, N.E., Huang, T.S., Lin, F.M., Lou, C.H., Wang, Y.T., Li, S., Kang, J., Munkacsi, H., Maurya, M.R., Gupta, S., Chien, S., Subramaniam, S., & Chen, Z. (2018). Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function. Nat Commun, 9(1), 292. https://doi.org/10.1038/s41467-017-02113-y
  29. Bzymek, K.P., Puckett, J.W., Zer, C., Xie, J., Ma, Y., King, J.D., Goodstein, L.H., Avery, K.N., Colcher, D., Singh, G., Horne, D.A., & Williams, J.C. (2018). Mechanically interlocked functionalization of monoclonal antibodies. Nat Commun, 9(1), 1580. https://doi.org/10.1038/s41467-018-03976-5
  30. Sen, S., Wang, F., Zhang, J., He, Z., Ma, J., Gwack, Y., Xu, J., & Sun, Z. (2018). SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORgammat activity in a PKC-theta-dependent manner. Proceedings of the National Academy of Sciences of the United States of America, 115(3), E458-e67. https://doi.org/10.1073/pnas.1717789115
  31. Awasthi, S., Tompkins, J., Singhal, J., Riggs, A.D., Yadav, S., Wu, X., Singh, S., Warden, C., Liu, Z., Wang, J., Slavin, T.P., Weitzel, J.N., Yuan, Y.C., Awasthi, M., Srivastava, S.K., Awasthi, Y.C., & Singhal, S.S. (2018). Rlip depletion prevents spontaneous neoplasia in TP53 null mice. Proceedings of the National Academy of Sciences of the United States of America, 115(15), 3918-23. https://doi.org/10.1073/pnas.1719586115
  32. Zhang, M., Racine, J.J., Lin, Q., Liu, Y., Tang, S., Qin, Q., Qi, T., Riggs, A.D., & Zeng, D. (2018). MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice. Proceedings of the National Academy of Sciences of the United States of America, 115(10), E2329-e37. https://doi.org/10.1073/pnas.1720169115
  33. Priceman, S.J., Gerdts, E.A., Tilakawardane, D., Kennewick, K.T., Murad, J.P., Park, A.K., Jeang, B., Yamaguchi, Y., Yang, X., Urak, R., Weng, L., Chang, W.C., Wright, S., Pal, S., Reiter, R.E., Wu, A.M., Brown, C.E., & Forman, S.J. (2018). Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer. Oncoimmunology, 7(2), e1380764. https://doi.org/10.1080/2162402X.2017.1380764
  34. Klempner, S.J., & Chao, J. (2018). Toward optimizing outcomes in Her2-positive gastric cancer: Timing and genomic context matter. Annals of Oncology, 29(4), 801-2. https://doi.org/10.1093/annonc/mdy066
  35. Luke, J.J., & Pal, S.K. (2018). Further evidence to support judicious use of antibiotics in patients with cancer. Annals of Oncology. https://doi.org/10.1093/annonc/mdy153
  36. Meng, Y., Li, H., Liu, C., Zheng, L., & Shen, B. (2018). Jumonji domain-containing protein family: the functions beyond lysine demethylation. J Mol Cell Biol. https://doi.org/10.1093/jmcb/mjy010
  37. Pang, K.M., Castanotto, D., Li, H., Scherer, L., & Rossi, J.J. (2018). Incorporation of aptamers in the terminal loop of shRNAs yields an effective and novel combinatorial targeting strategy. Nucleic Acids Research, 46(1), e6. https://doi.org/10.1093/nar/gkx980
  38. Yang, G., Liu, C., Chen, S.H., Kassab, M.A., Hoff, J.D., Walter, N.G., & Yu, X. (2018). Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensors. Nucleic Acids Research. https://doi.org/10.1093/nar/gky088
  39. Huang, L., Wang, Z., Narayanan, N., & Yang, Y. (2018). Arginine methylation of the C-terminus RGG motif promotes TOP3B topoisomerase activity and stress granule localization. Nucleic Acids Research, 46(6), 3061-74. https://doi.org/10.1093/nar/gky103
  40. Zhang, X., Castanotto, D., Liu, X., Shemi, A., & Stein, C.A. (2018). Ammonium and arsenic trioxide are potent facilitators of oligonucleotide function when delivered by gymnosis. Nucleic Acids Research. https://doi.org/10.1093/nar/gky150
  41. Sun, G., Wang, J., Huang, Y., Yuan, C.W., Zhang, K., Hu, S., Chen, L., Lin, R.J., Yen, Y., & Riggs, A.D. (2018). Differences in silencing of mismatched targets by sliced versus diced siRNAs. Nucleic Acids Research. https://doi.org/10.1093/nar/gky287
  42. Mendez-Dorantes, C., Bhargava, R., & Stark, J.M. (2018). Repeat-mediated deletions can be induced by a chromosomal break far from a repeat, but multiple pathways suppress such rearrangements. Genes & Development, 32(7-8), 524-36. https://doi.org/10.1101/gad.311084.117
  43. Komatsu, H., Rawson, J., Barriga, A., Gonzalez, N., Mendez, D., Li, J., Omori, K., Kandeel, F., & Mullen, Y. (2018). Posttransplant oxygen inhalation improves the outcome of subcutaneous islet transplantation: A promising clinical alternative to the conventional intrahepatic site. American Journal of Transplantation, 18(4), 832-42. https://doi.org/10.1111/ajt.14497
  44. Kirschbaum, M.H., Frankel, P., Synold, T.W., Zain, J., Claxton, D., Tuscano, J., Newman, E.M., Gandara, D.R., & Lara, P.N., Jr. (2018). A phase II study of vascular endothelial growth factor trap (Aflibercept, NSC 724770) in patients with myelodysplastic syndrome: a California Cancer Consortium Study. British Journal of Haematology, 180(3), 445-8. https://doi.org/10.1111/bjh.14333
  45. Wang, X., Walter, M., Urak, R., Weng, L., Huynh, C., Lim, L., Wong, C.W., Chang, W.C., Thomas, S.H., Sanchez, J.F., Yang, L., Brown, C.E., Pichiorri, F., Htut, M., Krishnan, A.Y., & Forman, S.J. (2018). Lenalidomide enhances the function of CS1 chimeric antigen receptor-redirected T cells against multiple myeloma. Clinical Cancer Research, 24(1), 106-19. https://doi.org/10.1158/1078-0432.CCR-17-0344
  46. Hsu, P.Y., Wu, V.S., Kanaya, N., Petrossian, K., Hsu, H.K., Nguyen, D., Schmolze, D., Kai, M., Liu, C.Y., Lu, H., Chu, P., Vito, C.A., Kruper, L., Mortimer, J., & Chen, S. (2018). Dual mTOR kinase inhibitor MLN0128 sensitize HRþ/HER2þ breast cancer patient-Derived xenografts to trastuzumab or fulvestrant. Clinical Cancer Research, 24(2), 395-406. https://doi.org/10.1158/1078-0432.CCR-17-1983
  47. Priceman, S.J., Tilakawardane, D., Jeang, B., Aguilar, B., Murad, J.P., Park, A.K., Chang, W.C., Ostberg, J.R., Neman, J., Jandial, R., Portnow, J., Forman, S.J., & Brown, C.E. (2018). Regional delivery of chimeric antigen receptor-engineered T cells effectively targets HER2+ breast cancer metastasis to the brain. Clinical Cancer Research, 24(1), 95-105. https://doi.org/10.1158/1078-0432.CCR-17-2041
  48. Stein, E.M., Walter, R.B., Erba, H.P., Fathi, A.T., Advani, A.S., Lancet, J.E., Ravandi, F., Kovacsovics, T., DeAngelo, D.J., Bixby, D., Faderl, S., Jillella, A.P., Ho, P.A., O'Meara, M.M., Zhao, B., Biddle-Snead, C., & Stein, A.S. (2018). A phase 1 trial of vadastuximab talirine as monotherapy in patients with CD33-positive acute myeloid leukemia. Blood, 131(4), 387-96. https://doi.org/10.1182/blood-2017-06-789800
  49. Caserta, E., Chea, J., Minnix, M., Viola, D., Vonderfecht, S., Yazaki, P., Crow, D., Khalife, J., Sanchez, J.F., Palmer, J.M., Hui, S., Carlesso, N., Keats, J., Kim, Y., Buettner, R., Marcucci, G., Rosen, S., Shively, J., Colcher, D., Krishnan, A., & Pichiorri, F. (2018). Copper 64-labeled daratumumab as a PET/CT imaging tracer for multiple myeloma. Blood, 131(7), 741-5. https://doi.org/10.1182/blood-2017-09-807263
  50. Budde, L.E., & Zaia, J.A. (2018). CD19 CAR-T therapy and sepsis: Dancing with the devil. Blood, 131(1), 7-8. https://doi.org/10.1182/blood-2017-11-812982
  51. Ma, H., Ursin, G., Xu, X., Lee, E., Togawa, K., Malone, K.E., Marchbanks, P.A., McDonald, J.A., Simon, M.S., Folger, S.G., Lu, Y., Sullivan-Halley, J., Deapen, D.M., Press, M.F., & Bernstein, L. (2018). Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis. Breast Cancer Res, 20(1), 5. https://doi.org/10.1186/s13058-017-0931-5
  52. Dieli-Conwright, C.M., Courneya, K.S., Demark-Wahnefried, W., Sami, N., Lee, K., Buchanan, T.A., Spicer, D.V., Tripathy, D., Bernstein, L., & Mortimer, J.E. (2018). Effects of Aerobic and Resistance Exercise on Metabolic Syndrome, Sarcopenic Obesity, and Circulating Biomarkers in Overweight or Obese Survivors of Breast Cancer: A Randomized Controlled Trial. Journal of Clinical Oncology, 36(9), 875-83. https://doi.org/10.1200/JCO.2017.75.7526
  53. Ramakrishna, C., & Cantin, E.M. (2018). IFNγ inhibits G-CSF induced neutrophil expansion and invasion of the CNS to prevent viral encephalitis. PLoS Pathogens, 14(1), e1006822. https://doi.org/10.1371/journal.ppat.1006822
  54. Aslamy, A., Oh, E., Olson, E.M., Zhang, J., Ahn, M., Md Moin, A.S., Tunduguru, R., Salunkhe, V.A., Veluthakal, R., & Thurmond, D.C. (2018). Doc2b Protects beta-Cells Against Inflammatory Damage and Enhances Function. Diabetes. https://doi.org/10.2337/db17-1352
  55. Mortimer, J.E., Bading, J.R., Park, J.M., Frankel, P.H., Carroll, M.I., Tran, T.T., Poku, E.K., Rockne, R.C., Raubitschek, A.A., Shively, J.E., & Colcher, D.M. (2018). Tumor uptake of 64Cu-DOTA-trastuzumab in patients with metastatic breast cancer. Journal of Nuclear Medicine, 59(1), 38-43. https://doi.org/10.2967/jnumed.117.193888
  56. van Megen, K.M., van 't Wout, E.T., Forman, S.J., & Roep, B.O. (2018). A future for autologous hematopoietic stem cell transplantation in type 1 diabetes. Front Immunol, 9(APR). https://doi.org/10.3389/fimmu.2018.00690
  57. Zhou, J., Lazar, D., Li, H., Xia, X., Satheesan, S., Charlins, P., O'Mealy, D., Akkina, R., Saayman, S., Weinberg, M.S., Rossi, J.J., & Morris, K.V. (2018). Receptor-targeted aptamer-siRNA conjugate-directed transcriptional regulation of HIV-1. Theranostics, 8(6), 1575-90. https://doi.org/10.7150/thno.23085
  58. Gong, J., Pan, K., Fakih, M., Pal, S., & Salgia, R. (2018). Value-based genomics. Oncotarget, 9(21), 15792-815. https://doi.org/10.18632/oncotarget.24353
  59. Sampath, S., Won, H., Massarelli, E., Li, M., Frankel, P., Vora, N., Vora, L., Maghami, E., & Kortylewski, M. (2018). Combined modality radiation therapy promotes tolerogenic myeloid cell populations and STAT3-related gene expression in head and neck cancer patients. Oncotarget, 9(13), 11279-90. https://doi.org/10.18632/oncotarget.24397
  60. Nagaprashantha, L.D., Singhal, J., Li, H., Warden, C., Liu, X., Horne, D., Awasthi, S., Salgia, R., & Singhal, S.S. (2018). 2'-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer. Oncotarget, 9(26), 18053-68. https://doi.org/10.18632/oncotarget.24720
  61. Poroyko, V., Mirzapoiazova, T., Nam, A., Mambetsariev, I., Mambetsariev, B., Wu, X., Husain, A., Vokes, E.E., Wheeler, D.L., & Salgia, R. (2018). Exosomal miRNAs species in the blood of small cell and nonsmall cell lung cancer patients. Oncotarget, 9(28), 19793-806. https://doi.org/10.18632/oncotarget.24857
  62. Chen, S.F., Liu, Z., Chaurasiya, S., Dellinger, T.H., Lu, J., Wu, X., Qin, H., Wang, J., Fong, Y., & Yuan, Y.C. (2018). Identification of core aberrantly expressed microRNAs in serous ovarian carcinoma. Oncotarget, 9(29), 20451-66. https://doi.org/10.18632/oncotarget.24942