The number of older patients with cancer and surviving cancer is rapidly growing because the U.S. population is aging with a projected doubling in the number of patients 65 and older by 2030. Although the majority of cancers occur in older adults, these patients have been under-represented in national cancer clinical trials, which set the standards for oncology care. Few studies have specifically focused on the unique issues which face older adults such as the impact of age related declines in physiology, polypharmacy or comorbid medical conditions on treatment tolerance.
Inspired by the pioneering work of Arti Hurria, M.D., who passed away in November 2018, the mission of City of Hope's Center for Cancer and Aging is to join investigators from all cancer disciplines to study biology, treatment and survivorship issues that face older adults with cancer. The results of this research will be applicable to the majority of patients with cancer because approximately 60 percent of cancer diagnoses and 70 percent of cancer mortality occur in patients over the age of 65.
Science to Meet a Critical Need
City of Hope is home to one of the few specialized research programs designed to meet the unique needs of older adults with cancer. This is a crucial area of study that will only grow in the coming years.
- Between 2010 and 2030, cancer incidence is expected to rise 67 percent in those age 65 or older, compared to 11 percent for those under age 65.
- Approximately 60 percent of all cancers occur in people aged 65 years or older.
- Older adults with cancer are underrepresented in the clinical trials that shape national standards for cancer care.
Older Adults Are Unique
- Utilizing the information gathered during the assessment, a score can be determined to predict which older adults will be at increased risk for chemotherapy side effects. Knowing which patients may suffer an increased risk of side effects could influence treatment decisions made by doctors and patients.
- Older adults typically have other medical conditions that need to be considered when choosing the type of therapy.
- Older adults often take several prescribed medications. A careful medication review needs to be performed in order to understand which can interact with cancer treatment.
- Older adults may have different preferences regarding treatments, taking into account the side effects of various treatment options and the impact of therapy on their ability to live independently.
Cancer and Aging Clinical Trials
IRB#06170 Determining the Utility of an Assessment Tool for Older Patients With Cancer
IRB#11127 Clinical and Biological Predictors of Chemotherapy Toxicity in Older Adults
IRB#08242 Longitudinal Impact of Neo-Adjuvant and Adjuvant Chemotherapy on Functional Status, Co-morbidity and Quality of Life
IRB#10112 Age Related Tolerability of the Combination of Lapatinib and Trastuzumab in HER2 Receptor Positive Metastatic Breast Cancer
IRB#11255 Older Breast Cancer Patients: Risk for Cognitive Decline
IRB#11139 Efficacy and Tolerability of Nanoparticle Albumin Bound Paclitaxel (Abraxane) in Patients 65 and Older with Metastatic Breast Cancer