Vaidehi Lab Members

[email protected]; [email protected] 

B.A., Chemistry, Hanyang University, Seoul, Korea 

M.S., Physical Chemistry, Hanyang University, Seoul, Korea 

Ph.D., Physical Chemistry, University of Florida 

Research interests: 

1. development of biased ligand on angiotensin II type 1 (AT1R) GPCRs, 
2. design of novel milder detergent for thermostabilized GPCRs

[email protected]; [email protected]
 

B.Sc., Chemistry, St. Xavier's College (autonomous) Kolkata, West Bengal, India 

M.Sc., Applied Chemistry, Indian Institute of Technology Dhanbad, Jharkhand, India 

Ph.D., Physical Chemistry, Indian Institute of Technology Bombay, Maharashtra, India 

Research interests: identifying thermostable point mutations for GPCRs using energy scores and evolutionary constraints, aggregation propensity of chemokine receptors using classical MD simulations

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B.E., Chemical Engineering, Jadavpur University, Kolkata, India 

M.Tech., Chemical Engineering, Indian Institute of Technology Guwahati, Guwahati, India 

Ph.D., Chemical Engineering, University of Kentucky, KY, USA. 

Research interests 
to develop and modify computational chemistry tools that can rapidly predict thermostabilizing mutations for membrane receptors, which is a critical step for receptor crystallization; understanding the stability of membrane receptors in various detergent micelles, important for protein extraction and purification

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B.S., Biology, Henan Normal University, Xinxiang, China 

M.S., Microbiology, Huaqiao University, Quanzhou, China 

Ph.D., Computational Chemistry, University of South Florida, Florida 

Research interests: kinase dynamics simulation, GPCR-membrane simulation, conformational free energy simulation, method development.

[email protected]; [email protected]

B.Tech., Bioinformatics, Vellore Institute of Technology University, Tamil Nadu, India 

Ph.D., Computational Chemistry, University of Georgia 

Research interests: biased agonism using classical MD simulations, biased ligand design, studying the effects of allosteric communication in GPCRs using MD and AlloSteer, understanding the molecular basis for subtype selectivity and method development.

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B.A., Biology, University of California Santa Barbara, Santa Barbara, California 

M.S., Biochemistry, California State University Northridge, Northridge, California 

Ph.D. (in progress) – Biology, Irell & Manella Graduate School of Biological Sciences, City of Hope, Duarte, California
 

Research interests: studying the molecular mechanisms of partial agonism and allostery in G protein coupled receptors, and how each process influences G protein selectivity

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B.S., Human Biology, University of California San Diego, San Diego, California 

Ph.D. currently obtaining, Computational Biophysics, Irell & Manella Graduate School of Biological Sciences, City of Hope, Duarte, California 

Research interests: delineating the structural features of the GPCR-G protein complex that lead to selective signaling to different G protein pathways

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B.Sc., Bioengineering, University of California Riverside, Riverside, California 

Research interests: applying machine learning in the study of GPCR thermostability

[email protected]; [email protected] 

B.Sc., Biomedical Engineering at Eindhoven University of Technology (TU/e), Eindhoven, Netherlands 

M.Sc., Biomedical Engineering at Eindhoven University of Technology (TU/e), Eindhoven, Netherlands 

Research interests: investigating GPCR c-term binding to G-protein through molecular dynamics simulations