Lymphoma SPORE

The overall goal of the City of Hope Lymphoma Specialized Program of Research Excellence (SPORE) is to develop novel therapies and preventative strategies to combat lymphoma, and rapidly advance them from laboratory studies to human clinical trials. 
This bench-to-bedside approach is known as “translational science” and the SPORE Program is part of the National Cancer Institute’s Translation Research Program (TRP). City of Hope holds one of only four lymphoma-focused SPOREs in the United States.
Our SPORE consists of six clinical trials, five of which utilize agents (cellular products, small molecules, radiolabeled antibodies) that are produced at City of Hope in our GMP Manufacturing Core and have been developed from our preclinical laboratory studies.

Principal Investigator Contacts

Stephen J. Forman, M.D.
Professor and Chair
Department of Hematology & Hematopoietic Cell Transplantation
City of Hope
1500 East Duarte Road
Duarte, CA 91010
Phone: 626-256-4673
Larry W. Kwak, M.D., Ph.D.
Vice President and Deputy Director, Comprehensive Cancer Center
City of Hope
1500 East Duarte Road
Duarte, CA 91010
Phone: 626-256-4673

Projects and Cores

Over the next five years, City of Hope doctors and researchers, as well as scientists from other institutions, will focus on the following projects and cores as part of the SPORE grant:
Project: CMV/CD19 bi-Specific CAR T cells combined with CMV vaccine as post-transplantation immunotherapy for non-Hodgkin lymphoma
Project Leaders: Stephen J. Forman, M.D., Ryotaro Nakamura, M.D., Donald J. Diamond, Ph.D., Xiuli Wang, Ph.D.

Project: Therapy-related leukemia following autologous transplantation for lymphoma
Project Leaders: Ravi Bhatia, M.D., Smita Bhatia, M.D.

Project: Targeted immunotherapy for relapsed/refractory Hodgkin lymphoma
Project Leaders: Eileen Smith, M.D., David M. Colcher, Ph.D., Alex Herrera, M.D.

Project: Novel nucleotide-based approaches targeting the STAT3 pathway for the treatment of lymphoma
Project Leaders: Hua Yu, M.D., Marcin Kortylewski, Ph.D., Elizabeth Budde, M.D.
Core A: Administrative: Support for Grant Administration and Program Organization
Core Leaders: Stephen J. Forman, M.D., Larry Kwak, M.D., Sandra H. Thomas, Ph.D.

Core B: Biostatistics and Research Informatics: Support for Data Coordination and Biostatistical Analysis
Core Leaders: Joycelynne Palmer, Ph.D. and Joyce Niland, Ph.D.

Core C: Lymphoma Tissue Bank: Provides blood and tissue banking for SPORE Projects
Core Leaders: John Chan, M.D. and Guido Marcucci, M.D.

Core D: Manufacturing
Core Leaders: Larry Kwak, M.D., David Horne, Ph.D.