Alexey Danilov Lab
Research Lab Overview
The Danilov lab focuses on early drug development in lymphoid malignancies, with a goal of ushering novel therapeutic approaches into clinic. The team follows the "bench to bedside" paradigm, where pre-clinical findings in the laboratory lead to initiation of early phase clinical trials in lymphoma. Subsequently, correlative studies advance understanding of cancer biology and drug pharmacodynamics, spurring progress in the field of molecular therapeutics. The lab investigates mechanistic aspects of targeted therapies and their immunomodulatory effects.
Clinical
- A Phase Ib/II study of Syk inhibitor entospletinib (GS-9973) in combination with obinutuzumab in patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and B-cell malignancies
- A Phase I Study of pevonedistat (MLN4924) in combination with ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia and non-Hodgkin lymphoma
- A Phase I Study of PI3Kα,δ Inhibitor Copanlisib in Combination with PD-1 Antagonist Nivolumab in Patients with Transformed Chronic Lymphocytic Leukemia (Richter's Transformation) or Non-Hodgkin Lymphoma
- A Phase II study of BTK inhibitor acalabrutinib in CLL and autoimmune hemolytic anemia
- A Phase II study of PI3K inhibitor duvelisib in CLL
- Effect of comorbidities on treatment outcomes in chronic lymphocytic leukemia
A board-certified clinician and talented researcher, Dr. Alexey Danilov's research focuses on lymphoma malignancies.
Lab Members
Lab Alumni
- Nur Bruss
- Tingting Liu
- Geeta Sharma
- Elana Thieme
- Dan Vuong
- Xiao Wang
- Scott Best – Graduate student, U Washington
- Taylor Rowland
- Daniel Coleman, P.h.D. – Staff Scientist, OHSU
- Adam Kittai MD – Assistant Professor of Medicine, Ohio State University
- J. Claire Godbersen – Staff Scientist
- Cody Paiva – Medical Student
- Leigh Ann Humphries, M.D. – OBGYN, UPenn
- Bhargava Sreekantham
- Peter Kebbekus, M.D., P.h.D. – Oncologist in Duluth, MN
- Sumner Kilmarx
- Ahsan Kamal
- Max Gordon
- Fei Xu, M.D.
Join one of our labs and help us on our mission to save lives.
Our Publications
Liu, T., Lam, V., Thieme, E., Sun, D., Wang, X., Xu, F., Wang, L., Danilova, O.V., Xia, Z., Tyner, J.W., Kurtz, S.E., and Danilov, A.V.
Gordon, M.J., Kaempf, A., Sitlinger, A., Shouse, G., Mei, M., Brander, D.M., …, Shadman, M., Park, B. and Danilov, A.V.
Kittai, A.S., Best, S., Thurlow, B., Lam, V., Hashiguchi, T., Goodyear, S., Persky, D.O., Okada, C., Park, B., Spurgeon, S. and Danilov, A.V.
Best, S., Lam, V., Liu, T., Bruss, N., Kittai, A., Danilova, O.V., Murray, S., Berger, A., Pennock, N.D., Lind, E.F. and Danilov, A.V.
Danilov, A.V. and Persky, D.O.
Contact Information
34.1291661, -117.9725847
Duarte, CA 91010
