Downtown Chicago

City of Hope | Downtown Chicago offers patients in and around Chicago consultations, treatments and other cancer care services in an outpatient setting, delivered by a team of experts who work closely with one another to understand each patient’s individual diagnosis and needs. Whether you’ve been recently diagnosed or you’re seeking a second opinion, our Downtown Chicago outpatient care center offers expertise that comes from working exclusively with cancer patients.

41.8909992, -87.6204582

160 Upper E. Illinois St.
Chicago, IL 60611

New Patients

(847) 342-6910

Current Patients

(312) 667-2822

Weekdays, 7:30 a.m. to 4 p.m.

Visitor Policy

Request Appointment

Clinical Services
Planning a Trip
Insurance Information

City of Hope cares for patients from prevention through survivorship by pairing our expertise in numerous cancers and conditions with world-class technologies and services.

Oncology Consultations

At any point in their cancer journey, patients can call or chat with a member of our team to make an appointment to meet with an expert in medical, radiation or surgical oncology at our Downtown Chicago outpatient care clinic. The oncologist will discuss whether additional tests or scans may be required, while walking patients through the next steps in their treatment journey. Our cancer experts work with patients to develop a personalized treatment plan based on their specific cancer type and stage.

Radiation and Infusion Therapy

The Downtown Chicago location offers on-site treatment options for patients who require radiation and infusion therapy, including chemotherapy, hormone therapy and other intravenous and injectable treatments.

Surgery

If patients require a surgical procedure, our hospital in Zion, Illinois, is staffed by a multidisciplinary surgical oncology team led by surgeons trained and experienced in a vast array of disciplines, including breast surgery, oncoplastic reconstruction, hyperthermic intraperitoneal chemotherapy (HIPEC) and neurosurgery.

Cyberknife

One of the unique benefits of the downtown location is that it is the only center in the Chicago city limits to offer CyberKnife radiation therapy technology. CyberKnife is a noninvasive option for some patients who have inoperable or surgically complex tumors, or who may be looking for an alternative to surgery. The CyberKnife system enables our radiation oncologists to deliver high, targeted doses of radiation to a broad range of tumors throughout the body, including in the colon, prostate, lung, brain, spine, liver, pancreas and kidney.

Supportive Care Services

Many patients underestimate how dramatically cancer can affect them, physically and emotionally. An integrative approach to cancer care treats the disease with radiation therapy, chemotherapy, surgery and other conventional treatments, while also supporting patients’ strength, stamina and quality of life with evidence-informed therapies. At City of Hope | Downtown Chicago, patients have access to supportive care services designed to help manage this important aspect of the cancer experience, so they are better able to stay on their treatment regimens and avoid delays or interruptions.

Parking is available at the Cityfront Garage located at 240 E. Upper Illinois St., Chicago, just east of the outpatient care center. Pedestrian elevators are in the southwest corner of the garage. Once you exit the garage, walk west on Illinois Street and cross St. Clair Street. The entrance to the outpatient care center will be on your right. Parking validation is available at the outpatient care center.

Public transportation options are also available close to the outpatient care center. Go to transitchicago.com to determine which option meets your needs.

Downtown Chicago map

City of Hope | Downtown Chicago accepts a variety of insurance plans. If you’re interested in learning more about becoming a patient, we can begin the insurance verification process immediately by obtaining your benefits information and contacting your insurance provider.

To get started or to find out more about becoming a patient, call us at or chat online with a member of our team.

Learn more

Explore City of Hope | Downtown Chicago

Located in the Streeterville neighborhood, City of Hope | Downtown Chicago offers patients in and around Chicago convenient access to personalized cancer care and state-of-the-art technologies.