Small Animal Imaging Core Publications
  • Silica Coated Paclitaxel Nanocrystals Enable Neural Stem Cell Loading For Treatment of Ovarian Cancer
    Pamela Tiet Jie Li Wafa Abidi Rachael Mooney Linda Flores Soraya Aramburo Jennifer Batalla-Covello Joanna Gonzaga Lusine Tsaturyan Yanan Kang Yvonne R. Cornejo Thanh Dellinger Ernest Han Karen S. Aboody Jacob M. Berlin

    Bioconjugate Chem. 2019, 30, 5, 1415-1424
  • IL15 Enhances CAR-T Cell Antitumor Activity by Reducing mTORC1 Activity and Preserving Their Stem Cell Memory Phenotype
    Darya Alizadeh, Robyn A Wong, Xin Yang, Dongrui Wang, Joseph R Pecoraro, Cheng-Fu Kuo, Brenda Aguilar, Yue Qi, David K Ann, Renate Star, Ryan Urak, Xiuli Wang, Stephen J Forman, Christine E Brown

    Cancer Immunol Res, 7 (5), 759-772
  • Arginine Starvation Kills Tumor Cells Through Aspartate Exhaustion and Mitochondrial Dysfunction
    Chun-Ting Cheng, Yue Qi, Yi-Chang Wang, Kevin K Chi, Yiyin Chung, Ching Ouyang, Yun-Ru Chen, Myung Eun Oh, Xiangpeng Sheng, Yulong Tang, Yun-Ru Liu, H Helen Lin, Ching-Ying Kuo, Dustin Schones, Christina M Vidal, Jenny C-Y Chu, Hung-Jung Wang, Yu-Han Chen, Kyle M Miller, Peiguo Chu, Yun Yen 5, Lei Jiang, Hsing-Jien Kung, David K Ann

    Commun Biol. 2018; 1: 178.

    This work was supported in part by funds from the National Institutes of Health R01DE10742, R21DE023298, R01DE026304, and R01CA220693 (to D.K.A.) and P30CA033572 (supporting research work carried out in City of Hope Core Facilities)
  • Optimization of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma
    Christine E. Brown, Brenda Aguilar, Renate Starr, Xin Yang, Wen-Chung Chang, Lihong Weng, Brenda Chang1 Aniee Sarkissian1 Alfonso Brito, James F. Sanchez, Julie R. Ostberg, Massimo D’Apuzzo, Behnam Badie, Michael E. Barish, and Stephen J. Forman

    Mol Ther. 2018 Jan 3; 26(1): 31–44
  • Copper 64-labeled Daratumumab as a PET/CT Imaging Tracer for Multiple Myeloma
    Enrico Caserta, Junie Chea, Megan Minnix, Erasmus K Poku, Domenico Viola, Steven Vonderfecht, Paul Yazaki, Desiree Crow, Jihane Khalife, James F Sanchez, Joycelynne M Palmer, Susanta Hui, Nadia Carlesso, Jonathan Keats, Young Kim, Ralf Buettner, Guido Marcucci, Steven Rosen, John Shively, David Colcher, Amrita Krishnan, Flavia Pichiorri

    Blood, 131 (7), 741-745 2018
  • Desmoplasia and Oncogene Driven Acinar-To-Ductal Metaplasia Are Concurrent Events During Acinar Cell-Derived Pancreatic Cancer Initiation in Young Adult Mice
    Benjamin L Johnson, Marcela d'Alincourt Salazar, Sarah Mackenzie-Dyck, Massimo D'Apuzzo, Hung Ping Shih, Edwin R Manuel, Don J Diamond

    PLoS One, 14 (9), e0221810 2019
  • CAR T Cells Targeting BAFF-R Can Overcome CD19 Antigen Loss in B Cell Malignancies
    Hong Qin, Zhenyuan Dong, Xiuli Wang, Wesley A Cheng, Feng Wen, Weili Xue, Han Sun, Miriam Walter, Guowei Wei, D Lynne Smith, Xiuhua Sun, Fan Fei, Jianming Xie, Theano I Panagopoulou, Chun-Wei Chen, Joo Y Song, Ibrahim Aldoss, Clarisse Kayembe, Luisa Sarno, Markus Müschen, Giorgio G Inghirami, Stephen J Forman, Larry W Kwak

    Sci Transl Med, 11 (511) 2019
  • Effective Targeting of TAG72 + Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells
    John P Murad, Anna K Kozlowska, Hee Jun Lee, Maya Ramamurthy, Wen-Chung Chang, Paul Yazaki, David Colcher, John Shively, Mihaela Cristea, Stephen J Forman, Saul J Priceman

    Front Immunol, 9, 2268 2018
  • PET of Adoptively Transferred Chimeric Antigen Receptor T Cells with 89Zr-Oxine.
    Weist MR, Starr R3, Aguilar B, Chea J, Miles JK, Poku E, Gerdts E, Yang X, Priceman SJ, Forman SJ, Colcher D, Brown CE, Shively JE.

    J Nucl Med. 2018 Oct;59(10):1531-1537.
  • Novel Chimeric Immuno-Oncolytic Virus CF33-hNIS-antiPDL1 for the Treatment of Pancreatic Cancer
    Yanghee Woo, Zhifang Zhang, Annie Yang, Shyambabu Chaurasiya, Anthony K Park, Jianming Lu, Sang-In Kim, Susanne G Warner, Daniel Von Hoff, Yuman Fong

    J Am Coll Surg 2020 Feb 4 [Online ahead of print]
  • RLIP Inhibition Suppresses Breast-To-Lung Metastasis
    Jyotsana Singhal, Shireen Chikara, David Horne, Ravi Salgia, Sanjay Awasthi, Sharad S Singhal

    Cancer Lett, 447, 24-32 2019
  • Metastasis of Breast Tumor Cells to Brain Is Suppressed by Targeting RLIP Alone and in Combination With 2'-Hydroxyflavanone
    Jyotsana Singhal, Preeti Singhal, David Horne, Ravi Salgia, Sanjay Awasthi, Sharad S Singhal

    Cancer Lett, 438, 144-153 201

    We thank the personnel in the Animal Research Center and Pathology Cores for their invaluable assistance. The authors are grateful to Dr. Jun Wu (Tumor Biology Core Lab, City of Hope) for technical assistance with intracardiac injections and animal imaging.
  • Mechanically interlocked functionalization of monoclonal antibodies
    Krzysztof P. Bzymek, James W. Puckett, Cindy Zer, Jun Xie, Yuelong Ma, Jeremy D. King, Leah H. Goodstein, Kendra N. Avery, David Colcher, Gagandeep Singh, David A. Horne, and John C. Williams

    Nat Commun. 2018; 9: 1580.
  • ImmunoPET, [64Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML Xenograft Model
    Sargur Madabushi Srideshikan, Jamison Brooks, Darren Zuro, Bijender Kumar, James Sanchez, Liliana Echavarria Parra, Marvin Orellana, Paresh Vishwasrao, Indu Nair, Junie Chea, Kofi Poku, Nicole Bowles, Aaron Miller, Todd Ebner, Justin Molnar, Joseph Rosenthal, Daniel A. Vallera, Jeffrey Y.C. Wong, Anthony S. Stein, David Colcher, John E. Shively, Paul J. Yazaki and Susanta K. Hui

    Clin Cancer Res, 25 (24), 7463-7474 2019
  • Novel BAFF-Receptor Antibody to Natively Folded Recombinant Protein Eliminates Drug-Resistant Human B-cell Malignancies In Vivo
    Hong Qin, Guowei Wei, Ippei Sakamaki, Zhenyuan Dong, Wesley A. Cheng, D. Lynne Smith, Feng Wen, Han Sun, Kunhwa Kim, Soungchul Cha, Laura Bover, Sattva S. Neelapu and Larry W. Kwak

    Clin Cancer Res, 24 (5), 1114-1123 2018
  • Antibody Targeted PET Imaging of 64Cu-DOTA-Anti-CEA PEGylated Lipid Nanodiscs in CEA Positive Tumors.
    Wong P, Li L, Chea J, Hu W, Poku E, Ebner T, Bowles N, Wong JYC, Yazaki PJ, Sligar S, Shively JE.

    Bioconjug Chem. 2020 Jan 30. doi: 10.1021/acs.bioconjchem.9b00854. [Epub ahead of print]
  • Evaluation of [68Ga]DO3A-VS-Cys40-Exendin-4 as a PET Probe for Imaging Human Transplanted Islets in the Liver.
    Li J, Rawson J, Chea J, Tang W, Miao L, Sui F, Li L, Poku E, Shively JE, Kandeel F.

    Sci Rep. 2019 Apr 5;9(1):5705.
  • CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes.
    Zhang Z, La Placa D, Nguyen T, Kujawski M, Le K, Li L, Shively JE.

    BMC Immunol. 2019 Jan 23;20(1):7. doi: 10.1186/s12865-019-0287-y.
  • A Novel Chimeric Poxvirus Encoding hNIS Is Tumor-Tropic, Imageable, and Synergistic with Radioiodine to Sustain Colon Cancer Regression
    Susanne G. Warner, Sang-In Kim, Shyambabu Chaurasiya, Michael P. O’Leary, Jianming Lu, Venkatesh Sivanandam, Yanghee Woo, Nanhai G. Chen, and Yuman Fong

    Mol Ther Oncolytics. 2019 Jun 28; 13: 82–92.