X-Ray Crystallography Publications

Chen SH1, Yu X1. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340. doi: 10.1126/sciadv.aav4340

King JD, Ma Y, Kuo YC, Bzymek KP, Goodstein LH, Meyer K, Moore RE, Crow D, Colcher DM, Singh G, Horne DA, Williams JC. Template-Catalyzed, Disulfide Conjugation of Monoclonal Antibodies Using a Natural Amino Acid Tag. Bioconjug Chem. 2018 Jun 20;29(6):2074-2081. doi: 10.1021/acs.bioconjchem.8b00284. Epub 2018 May 25. PubMed PMID: 29763554.

Bzymek KP, Puckett JW, Zer C, Xie J, Ma Y, King JD, Goodstein LH, Avery KN, Colcher D, Singh G, Horne DA, Williams JC. Mechanically interlocked functionalization of monoclonal antibodies. Nat Commun. 2018 Apr 20;9(1):1580. doi: 10.1038/s41467-018-03976-5. PubMed PMID: 29679060; PubMed Central PMCID: PMC5910394.

Herrmann A, Lahtz C, Nagao T, Song JY, Chan WC, Lee H, Yue C, Look T, Mülfarth R, Li W, Jenkins K, Williams J, Budde LE, Forman S, Kwak L, Blankenstein T, Yu H. CTLA4 Promotes Tyk2-STAT3-Dependent B-cell Oncogenicity. Cancer Res. 2017 Sep 15;77(18):5118-5128. doi: 10.1158/0008-5472.CAN-16-0342. Epub 2017 Jul 17. PubMed PMID: 28716895; PubMed Central PMCID: PMC5600851.

Zer C, Avery KN, Meyer K, Goodstein L, Bzymek KP, Singh G, Williams JC. Engineering a high-affinity peptide binding site into the anti-CEA mAb M5A. Protein Eng Des Sel. 2017 Jun 1;30(6):409-417. doi: 10.1093/protein/gzx016. PubMed PMID: 28431161; PubMed Central PMCID: PMC5914451.

Roberts CM, Shahin SA, Loeza J, Dellinger TH, Williams JC, Glackin CA. Disruption of TWIST1-RELA binding by mutation and competitive inhibition to validate the TWIST1 WR domain as a therapeutic target. BMC Cancer. 2017 Mar 10;17(1):184. doi: 10.1186/s12885-017-3169-9. PubMed PMID: 28283022; PubMed Central PMCID: PMC5345230.

Bzymek KP, Avery KA, Ma Y, Horne DA, Williams JC. Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun. 2016 Nov 1;72(Pt 11):820-830. doi: 10.1107/S2053230X16016149. Epub 2016 Oct 24. PubMed PMID: 27834791; PubMed Central PMCID: PMC5101583.

Hillmann F, Bagramyan K, Straßburger M, Heinekamp T, Hong TB, Bzymek KP, Williams JC, Brakhage AA, Kalkum M. The Crystal Structure of Peroxiredoxin Asp f3 Provides Mechanistic Insight into Oxidative Stress Resistance and Virulence of Aspergillus fumigatus. Sci Rep. 2016 Sep 14;6:33396. doi: 10.1038/srep33396. PubMed PMID: 27624005; PubMed Central PMCID: PMC5022050.