Charles Brenner, Ph.D.

Duarte - Main Campus
Duarte, CA 91010
1988-1993, Ph.D., Cancer Biology, Stanford University, Stanford, CA
1979-1983, B.A. with honors, Biology, Wesleyan University Middletown, CT
1993-1996, Postdoctoral Fellow with Drs. Gregory A. Petsko & Dagmar Ringe, Brandeis University, Waltham, MA
2020-present, Alfred E Mann Family Foundation Chair & Professor, Department of Diabetes & Cancer Metabolism, Beckman Research Institute, City of Hope, Duarte, CA
2009-2020, Roy J. Carver Chair & Head, Department of Biochemistry, Professor of Internal Medicine, Founding Director, University of Iowa Obesity Initiative, University of Iowa, Iowa City, IA
2003-2009, Associate Professor (2003-2007), Professor (2007-2009), Departments of Genetics and of Biochemistry, Director, Cancer Mechanisms Program (2003-2009), Associate Director, Basic Sciences, Norris Cotton Cancer Center (2008-2009), Dartmouth Medical School, Lebanon, NH
1996-2003, Assistant Professor (1996-2000), Associate Professor (2000-2003), Department of Microbiology & Immunology, Director (2000-2003), Structural Biology Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA
1986-1988, Research Assistant with Dr. Kunihiro Matsumoto, DNAX Research Institute, Palo Alto, CA
1983-1985, Research Assistant with Dr. Anthony J. Brake, Chiron Corporation, Emeryville, CA
2023, American Society for Biochemistry and Molecular Biology
2020, Mary Swartz Rose Senior Investigator Award, American Society of Nutrition
2019, Keynote Lecturer at Norway AGE Conference on NAD, Oslo
2018, Keynote Lecturer at 15th International Symposium on Milk Genomics & Human Health, Sacramento
2018, Dartmouth Technology Transfer Innovation and Commercialization Award
2018, Keynote, Nutritional Ingredients Association-West, Laguna Beach, CA
2017, Co-chair, FASEB Conference on NAD Metabolism and Signaling, New Orleans, LA
2016, Keynote, Lecturer, Des Moines University Regional Research Symposium
2016, CNIO Distinguished Lecturer, Madrid
2016, ASBMB Award for Exemplary Contributions to Education
2015, Keynote Lecturer, Annual Pathobiology Retreat, Brown University
2015, Ackerman Student Lecturer in Biochemistry and Redox Biology, University of Nebraska Lincoln
2014, State of Iowa Regents Award for Faculty Excellence
2012, Fellow of the American Association for Advancement of Science
2012, Holden Comprehensive Cancer Center Oberley Award
2012-2016, ASBMB Today, Chair, Editorial Advisory Board
2009-2012, ASBMB Publications Committee, Chair, 2011-2012
2009, Co-chair, FASEB Conference on NAD Metabolism and Signaling, Carefree, Arizona
2008, Lung Cancer Research Foundation Awardee
2007, William E.M. Lands Lecturer in Nutritional Biochemistry, University of Michigan
1998-2001, Burroughs Wellcome Foundation New Investigator in Pharmacological Sciences
1998-2000, Beckman Young Investigator, Arnold and Mabel Beckman Foundation
1998-2000, Basil O’Connor Scholar, March of Dimes Birth Defects Foundation
1994, Leukemia Society of America Short-Term Scientific Exchange Award, Max-Planck-Institut, Dortmund
1993-1996, Fellow of the Leukemia Society of America, Brandeis University
1988-1992, Program in Cancer Biology trainee, Department of Biochemistry, Stanford University
1979-1983, National Merit Scholar, Wesleyan University
1979-1980, Connecticut State Scholar, Wesleyan University
- P. H. Ear, A. Chadda, S. B. Gumusoglu, M. S. Schmidt, S. Vogeler, J. Malicoat, J. Kadel, M. M. Moore, M. E. Migaud, H. E. Stevens & C. Brenner, “Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring,” Cell Reports. v. 26 (4), pp. 969-983 (2019). DOI: 10.1016/j.celrep.2019.01.007
- N.R. Fons, R.K. Sundaram, G.A. Breuer, S. Peng, R.L. McLean, A.N. Kalathil, M.S. Schmidt, D.M. Carvalho, A. Mackay, C. Jones, A.M. Carcaboso, J. Nazarian, M.E. Berens, C. Brenner, & R.S. Bindra., “PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma,” Nature Communications, v. 10, 3790 (2019). DOI: 10.1038/s41467-019-11732-6
- R. Parker, M.S. Schmidt, O. Cain, B. Gunson & C. Brenner, “The NAD+ Metabolome is Functionally Depressed in Patients Undergoing Liver Transplantation for Alcohol-related Liver Disease,” Hepatology Communications, v. 4, pp.1183-1192 (2020) DOI: 10.1002/hep4.1530
- T.S. Nam, D.R. Park, S.-Y. Rah, T.G. Woo, H.T. Chung, C. Brenner & U.-H. Kim. “Interleukin-8 drives CD38 to form NAADP from NADP+ and NAAD in the endolysosomes to mobilize Ca2+ and effect cell migration” FASEB Journal, v.34, pp. 12565-12576 (2020) DOI: 10.1101/2020.03.24.004739
- C.D. Heer, D.J. Sanderson, L.S. Voth, Y M.O. Alhammad, M.S. Schmit, S.A.J. Trammell, S. Perlan, M.S. Cohen, A.R. Fehr & C. Brenner “Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity” Journal of Biological Chemistry, v. 295, pp. 17986-17996 (2020) DOI:10.1074/jbc.RA120.015138