
Want to end cancer? So do we.
Apply now to join us in fulfilling our mission to make hope a reality for all impacted by cancer.
A Top Place to Work
City of Hope Orange County has been named a Best Place to Work in the nation by Modern Healthcare and a top place to work in Orange County for three years by Orange County Business Journal. A culture of compassion, collaboration and commitment means our employee engagement scores are among the top 5% of 41,000 health care institutions.
Each of us at City of Hope Orange County believes in bringing hope closer to home for the nation’s sixth largest county. We have assembled the nation’s top cancer experts who answered the call to end cancer in this region and beyond.
Every researcher, nurse, physician, administrative professional or IT specialist brings their unique creativity and talent toward fulfilling this promise. Whether your interest is in the clinical, business, science or support service area, at City of Hope Orange County we’re solely focused on cancer and ensuring that we hold our patients’ hand and never let go.
City of Hope Orange County operates the largest and most advanced network of highly specialized cancer research and treatment for the region’s 3.2 million residents. Several clinical locations throughout OC and neighboring Long Beach and our academic cancer campus in Irvine are home to many of the nation’s top cancer experts.
Located along the Southern California coastline, Orange County is renowned for its blend of suburban charm and urban amenities, making it a desirable place to live. Orange County is one of the most multiculturally diverse regions in the nation. It is home to world-famous colleges and universities, amusement parks, sports stadiums, and cultural activities.
Irvine, home to our regional headquarters, is consistently ranked as one of the safest and best places to live in the United States and home to some of the top-rated schools in the nation. Irvine is a global technology and innovation hub, with major employers in technology, finance and healthcare.
At City of Hope Orange County, we put our staff and our patients first. We have infused DE&I into our DNA. We’ve established a culture of listening, learning, and growing, both personally and professionally. We bring our whole selves to work in our quest for human connection. We partner with our employees and seek their input. For we believe in maintaining an honest, transparent, and inclusive relationship with all who join us in the search for new treatments and cures for cancer.

We’re Hiring: Join OC’s Only Cancer Specialty Hospital
Opening in late 2025, we are currently hiring nearly 500 new staff, with fulfilling roles in food services, nursing, pharmacy, lab, environment services, research, surgical services, supportive care, integrative medicine and more. Roles are also available today in locations throughout Southern California.
There are rare moments in one's career when the chance to make a significant impact presents itself. City of Hope Orange County is seeking the nation's top health care professionals — from chefs to laboratory techs to nurses — join our team to complete the full continuum of advanced cancer research and treatment for the nation's sixth largest county.

We’re recruiting expert physicians to join the academic cancer research and treatment team at City of Hope Orange County. Work at the epicenter of cancer innovations and cures while serving a mission that will benefit generations to come.

This is the care Orange County needs today. Slated for completion in 2025, this six-story structure will be seamlessly connected to City of Hope Orange County Lennar Foundation Cancer Center. Where other hospitals must serve the full spectrum of health conditions in our community, every team member at this cancer specialty hospital — from the nurses to nutritionists to physicians — will have a core focus on oncology.

Unlock Exceptional Benefits When You Join Our Team
At City of Hope, we’re dedicated to supporting your physical, emotional and financial well-being. When you join our team, you gain access to a comprehensive benefits package designed to help you thrive in both your professional and personal life. In addition to extensive health and financial benefits, we offer continuous opportunities for career development and growth.
Your benefits take effect on the first day of the month following your start date. As a regular full-time or part-time employee working at least 20 hours per week, you’ll be able to participate in City of Hope’s exceptional benefits programs.
- Competitive HMO, PPO and HDHP Medical Plans
- Vision, Dental and Flexible Spending Account programs
- Basic Life, AD&D and Disability Insurance with supplemental coverage options
- Employee Assistance Program, including confidential mental health support
- Employee Wellness Program with robust participation incentives
- Health Care Management Resources to help you manage musculoskeletal pain, surgery, diabetes and weight
- Family-Forming Benefits
- AccessHope Cancer Support Services
- 403(b) Retirement Plan, employee-funded by pre-tax and/or Roth after tax contributions
- 401(a) Retirement Plan, employer-funded with 2-10% of eligible earnings
- Annual Incentive Plan for eligible leaders
- Employee Giving Program
- Identity Theft Protection
- Pet Insurance
- Legal Services Coverage
- Back-Up Child and Adult/Elder Care
- 7 Holidays
- 10 Sick Days
- 3 Personal Holidays Days
- 2-4 Weeks of Vacation
- Unlimited Leadership Time Off Program for Eligible Leaders
- Ongoing Professional Development Training Programs
- Tuition Assistance Program
- Learning & Professional Development Week
- Leadership Academy
- Rideshare and Alternative Commute Program
- Employer subsidy and discounts for Public Transportation
Hear From Our Inspiring Employees
