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Orange County Newsroom

City of Hope Orange County leaders and physicians are available to provide commentary on a wide range of healthcare topics and cancer-focused news, trends and research. Interviews with leaders, physicians and patients or visits to the cancer center can be arranged by emailing:
A New City of Hope Orange County Report Reveals Concerning Trends About Cancer in Younger Adults in Southern California

City of Hope Orange County, the most advanced cancer research and treatment organization in Orange County, has released a report that evaluates the cancer incidence rate in people ages 18 and 49 in Orange County and Southern California amid a national epidemic of early-onset cancer diagnoses.

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Younger Face of Cancer

In the News

Retraction questions claim that cancer therapy works better in morning

June 24, 2026

Nature Medicine has retracted a high-profile lung cancer study that claimed morning immunotherapy greatly improved survival, citing major concerns about data integrity and trial design. City of Hope's Sumanta Pal, M.D., criticized the biological plausibility, telling STAT at the time that there were few compelling reasons why treatment timing would matter, as antibody levels decline slowly over weeks. Pal’s skepticism, shared by other experts, contributed to heightened scrutiny and ultimately the retraction, highlighting the need for rigorous validation before changing clinical practice.

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Breast cancer researchers explore less invasive treatment options

June 24, 2026

City of Hope hosted a forum on breast cancer research, exploring less invasive treatments. City of Hope's Hope Rugo, M.D., discussed optimizing treatment and quality of life. City of Hope Orange County's Irene Kang, M.D., presented the Optima Study, showing chemotherapy may not be necessary for some early stage breast cancers. City of Hope's Veronica Jones, M.D., detailed the Senomac Trial, which supports limiting axillary surgery for better patient outcomes. Rugo also noted the effectiveness of pembrolizumab for triple negative breast cancer.

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Press Releases & Statements

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Hear breakthrough conversations about preventing, treating and curing cancer, brought to you by City of Hope, a National Cancer Institute-designated comprehensive cancer center offering Orange County’s most advanced cancer care. The Science of Cancer Survival Starts Here.

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Orange County Stories

At a Lennar giving event, a person demonstrating the "A gift of hope" poster
City of Hope
A Gift of Hope to Orange County
Thanks to a $50 million gift from Lennar Foundation, cancer patients in the Orange County community will be able to get groundbreaking treatment and world-class care locally at Lennar Foundation Cancer Center, opening in 2022 in Irvine.
Orange County
Hope and Healing Garden
City of Hope Orange County
Hope and Healing Garden Named in Recognition of Transformative $25 million Gift from Argyros Family
City of Hope Orange County received a transformative gift of $25 million from the Argyros family in September. The exciting news was announced by Julia Argyros at the Hope Gala September 10.
Orange County
Donor Story
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Media Gallery

Faith Leaders and Annette Walker inside The Wetterau Family Spiritual Care Center
City of Hope Orange County Activation at South Coast Plaza
City of Hope Orange County Hospital Key Ceremony
Orange County Hospital Construction Team
City of Hope Orange County Celebrating Cancer Survivors

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