Diabetes Clinical Trials
The Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope is committed to turning scientific discoveries into new strategies to treat, diagnosis, prevent and cure diabetes. Some clinical trials are designed to test the safety and/or effectiveness of promising new treatments that are not yet approved. Other studies gather information, such as questionnaires or blood samples, to help develop future treatment advances.
ONGOING CLINICAL TRIALS
IRB# 18156: Improving Islet Transplantation Outcomes with Gastrin
ENROLLING ADULTS WITH TYPE 1 DIABETES
AGES 18-68 | 5 years or more from diagnosis
- Principal Investigator: Fouad Kandeel, MD, PhD
- To learn more visit: http://www.clinicaltrials.gov/ct2/show/NCT03746769
- Learn more about islet cell transplantation
IRB# 23797: A Phase 1/2 Prospective, Randomized, Double-blind, Placebo-controlled Multi-center Clinical Trial to Determine the Safety and Efficacy of Denosumab in Improving Beta Cell Function and Glycemic Control Among Patients with Type 1 Diabetes
ENROLLING ADULTS WITH TYPE 1 DIABETES
AGES 18-50 | 1-5 years from diagnosis
- Principal Investigator: Fouad Kandeel, MD, PhD
- Co-Investigator: Rupangi Vasavada, PhD
- To learn more visit: http://www.clinicaltrials.gov/ct2/show/NCT06524960
IRB# 24745: A Randomized Phase 1/2 Trial of Low Dose Anti-Thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes (WAVE T1D)
ENROLLING CHILDREN & YOUNG ADULTS WITH TYPE 1 DIABETES
AGES 9-20 | Within 6 months of diagnosis
- Study Chair: Alberto Pugliese, MD
- This clinical trial is sponsored by City of Hope and being conducted at collaborating sites across the U.S.
- To learn more visit: https://clinicaltrials.gov/study/NCT07061574 or https://www.jaeb.org/wavet1d/
IRB# 25773: POLARIS: A Phase 1, Single Dose, Open-Label Study of GNTI-122 in Adults with Recently Diagnosed Type 1 Diabetes (T1D)
ENROLLING ADULTS WITH TYPE 1 DIABETES
AGES 18-55 | Within 180 days of diagnosis
- Principal Investigator: Fouad Kandeel, MD, PhD
- To learn more visit: https://clinicaltrials.gov/study/NCT06919354 or https://www.polarisstudy.com/
COMING SOON
The following clinical trial(s) are not yet enrolling, but are coming soon.
IRB# 24895: Autologous CD6-CAR Treg Cells for Patients With Stage 3 Type 1 Diabetes
ADULTS WITH TYPE 1 DIABETES
AGES 18-35 | Within 12-24 months of diagnosis
- To learn more visit: https://clinicaltrials.gov/study/NCT07395050
Several new clinical trials are in development and expected to begin in the coming months/years. Please check back often.