The Hematopoietic Tissue Biorepository (HTB) Core was established to help further understand all aspects of normal and aberrant hematopoiesis. Its primary goal is to support high-quality, translational and clinical research on hematological diseases and malignancies by providing biological specimens of interest to investigators at City of Hope and other affiliated research institutions.
Our Mission and Vision
City of Hope’s mission is to transform the future of health care by providing blood- and bone marrow-derived cellular products, buccal cell specimens for germline nucleic acids, normal skin cells, and all associated medical information to conduct innovative research. We streamline and standardize access to research samples from both common and rare diseases, which might otherwise take years to collect for individual projects, allowing researchers to develop novel therapies, diagnostics, and the cures of the future. Our vision is to collect and bank a comprehensive tissue panel from newly diagnosed or newly relapsed participants over the full spectrum of hematological diseases seen at City of Hope.
We can consent willing participants; procure, process, store; distribute samples; and maintain all collected specimens and clinical data in our database.
We've banked specimens in acute and chronic leukemia, myelodysplastic syndrome, myeloproliferative neoplasms, multiple myeloma, lymphomas, anemias, and many more. We can distribute these samples to investigators at City of Hope and other collaborating institutions, which have obtained protocol approval from the HTB’s biorepository committee and City of Hope’s Institutional Review Board.
We prospectively collect specimens to fulfill research needs.
We offer various processing services such as bone marrow and peripheral blood mononuclear cell separations, nucleic acid extractions, and leukocyte processing.
We can obtain immunophenotypically characterized monoclonal cell subpopulations and have the ability to store skin biopsy, buccal cell samples and microbiome.
2x Sterilguard II Class 2 Type A/B3 Biosafety Cabinets
These are Class II Type A/B3 biosafety cabinets with vertical laminar airflow and ultraviolet light. They provide a sterile environment when working with biological specimens, e.g., peripheral blood, bone marrow and cell lines.
Two Thermo Scientific Legend XR1 Centrifuges and one Beckman Coulter Allegra X14R Centrifuge. The centrifuges have programmable settings, temperature variations, and various conical tube size adapters.