An NCI-designated Comprehensive Cancer Center

Brain Tumors

Getting treatment for brain and spinal tumors at City of Hope puts you at the center of the most innovative and groundbreaking research and clinical trials for brain cancer in the world. It gives you access to promising treatments that directly target tumors — and the biology of your individual cancer.

Our Brain Tumor Program has several exciting experimental therapies — some of which are only offered at City of Hope — as part of our clinical trials program. We are pioneering new treatments for brain tumors including:

  • Genetically fortified immune system cells called CAR T cells; a groundbreaking case study, conducted here and published in the New England Journal of Medicine, found CAR T cell therapy to be effective in the treatment of glioblastoma.
  • Neural stem cells modified to deliver chemotherapy to advanced and treatment-resistant brain cancer
  • Nanoparticles that unleash cancer-killing therapies directly at tumor sites

Clinical trials for brain cancer

If you have a newly developed or recurrent brain tumor and are interested in learning about our clinical trials, or in referring a patient for enrollment, please call 844-333-HOPE (4673) or send an email to [email protected].


Request a consultation

If you have been diagnosed with acute myeloid leukemia or are looking for a second opinion consultation about your treatment, you may request an appointment online or contact us at 800-826-4673 (HOPE). Please visit Making Your First Appointment for more information. 

Our Expertise

“In the past we never treated patients who had cancer that spread to the brain because we considered it terminal. But now that we’ve succeeded with drugs, partly invented at City of Hope, people with advanced cancer are living longer and longer.”
Rahul Jandial, M.D., Ph.D., neurosurgeon and scientist
Jandial 300x300 Impact

Rahul Jandial, M.D., Ph.D.

When you get brain tumor treatment at City of Hope, you are partnering with a world-class team of experts spanning multiple disciplines, who see and treat challenging and complex brain tumors on a daily basis. And you have access to transformative surgical methods and technology, groundbreaking research studies and highly focused radiation therapy. We treat all tumor types, including:

Promising new therapies

City of Hope’s focus on basic research keeps us on the cusp of big discoveries. We are the only cancer center in the country that is injecting cancer-killing immune cells directly into the brain to treat patients with advanced brain tumors — to boost your immune system's natural cancer-fighting abilities. And we were the first research institution in the world to use neural stem cells in patients with glioblastoma.

Our commitment to providing exceptional care includes:

  • Advanced immunotherapy and gene therapy clinical trials including using modified T cells to fight brain tumors
  • Revolutionary neural stem cell therapy that delivers chemotherapy directly to tumors
  • Promising research into immunotherapeutic approaches to killing brain cancer cells using nanoparticles
  • Neurosurgeons who expertly perform minimally invasive procedures — including endoscopic and image-guided surgery — to remove as much tumor tissue as possible while preserving quality of life
  • A comprehensive pituitary tumor clinic
  • Noninvasive, alternating electric field therapy that disrupts tumor cell division
  • A brain tumor board that meets at least twice a month to discuss patient treatment plans, allowing for tailored and individualized treatment
  • Palliative procedures designed to improve quality of life

Seamless, coordinated care

City of Hope’s team of neurosurgeons, neurooncologists, researchers, nurses, radiation oncologists and genetic counselors work together closely at all stages to provide seamless, coordinated care. We balance that approach with personalized medicine — not just when it comes to your cancer, but the kind that makes you feel supported throughout your treatment. And our commitment to personalized care means preserving your quality of life is at the heart of your treatment.

City of Hope is internationally recognized for its research and breakthrough treatments, has been named one of America’s top cancer hospitals by U.S. News & World Report for more than a decade, and is a National Cancer Institute-designated comprehensive cancer center.

Request a consultation

City of Hope’s world-renowned brain tumor care team uses the latest technology and innovation to treat cancer while providing compassionate care. Call 800-826-HOPE or request an appointment online.

News & Breakthroughs


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